Cluster headache

AKA histaminic migraine. Actually a neurovascular event, distinct from true migraine.

Cluster headache belongs to a group of primary headache disorders, classified as the trigeminal autonomic cephalalgias or (TACs). Cluster headache is named after the demonstrated grouping of headache attacks occurring together (cluster).

Cluster headaches may also be known as histamine headache, red migraine, Horton’s headache, and cephalalgia or sphenopalatine neuralgia.

Male: female ratio is ≈ 5:1. 25% of patients have a personal or family history of migraine. 1).

The pain and autonomic symptoms of cluster headache (CH) result from activation of the trigeminal parasympathetic reflex, mediated through the sphenopalatine ganglion (SPG).

Low frequency (LF) SPG stimulation may induce cluster-like attacks with autonomic features, which can subsequently be treated by HF SPG sphenopalatine ganglion stimulation. Efferent parasympathetic outflow from the SPG may initiate autonomic symptoms and activate trigeminovascular sensory afferents, which may initiate the onset of pain associated with CH 2).

Recurrent unilateral attacks of severe pain. Usually oculofrontal or oculotemporal with occasional radiation into the jaw, usually recurring on the same side of the head. Ipsilateral autonomic symptoms (conjunctival injection, nasal congestion, rhinorrhea, lacrimation, facial flushing) are common. Partial Horner syndrome (ptosis and miosis) sometimes occurs.

Headaches characteristically have no prodrome, last 30–90 minutes, and recur one or more times daily, usually for 4–12 weeks, often at a similar time of day, following which there is typically a remission for an average of 12 months 3).

Individuals typically experience repeated attacks of excruciatingly severe unilateral headache pain.

Cluster headache attacks often occur periodically; spontaneous remissions may interrupt active periods of pain, though about 10–15% of chronic CH never remit. The cause of cluster headache has not been identified.

see Cluster headache treatment.

A 41-year-old man presented with a 3-month history of side-locked attacks of excruciating severe stabbing and boring right-sided pain located in the temple and the orbit. The attacks were associated with conjunctival injection and restlessness and migrainous features. The duration of attacks was about 30 minutes and the frequency 4 to 5 per 24 hours. His vital signs and physical and neurological examination were normal. A previous unenhanced brain computed tomography had been normal. A diagnosis of CH was made. The patient responded partially to treatment. Enhanced magnetic resonance imaging after 3 weeks displayed a right-sided parietal glioma with a surrounding edema and mass effect. After debulking, the headache attacks resolved completely.

Contrast-enhanced magnetic resonance imaging should always be considered in patients with CH despite earlier normal head computed tomography/examinations. Late-onset CH represents a condition that requires careful evaluation. Parietal glioblastoma multiforme can present as CH. 4).

1) , 3)
Kittrelle JP, Grouse DS, Seybold ME. Cluster Headache: Local Anesthetic Abortive Agents. Arch Neurol. 1985; 42:496–498
Schytz HW, Barløse M, Guo S, Selb J, Caparso A, Jensen R, Ashina M. Experimental activation of the sphenopalatine ganglion provokes cluster-like attacks in humans. Cephalalgia. 2013 Jul;33(10):831-41. doi: 10.1177/0333102413476370. Epub 2013 Feb 4. PubMed PMID: 23382519.
Edvardsson B, Persson S. Cluster headache and parietal glioblastoma multiforme. Neurologist. 2012 Jul;18(4):206-7. doi: 10.1097/NRL.0b013e31825cf181. PubMed PMID: 22735247.
  • cluster_headache.txt
  • Last modified: 2020/01/17 09:59
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