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cognitive_disorder

Cognitive disorder

Cognitive fatigability

Cognitive decline is a deterioration in cognitive function.

see Cognitive disorder after traumatic brain injury.

see Cognitive disorder after subarachnoid hemorrhage.

Several studies claimed that surgery in eloquent areas is possible without causing severe cognitive decline. However, this conclusion was relatively ungrounded due to the lack of extensive neuropsychological testing in homogenous patient groups.


Liu et al. retrospectively enrolled 92 consecutive patients with confirmed diagnosis of Cushing's disease. A voxel-based analysis was performed to investigate the association between cerebral (18)F-fluorodeoxyglucose uptake and serum cortisol level. Relatively impaired metabolism of specific brain regions correlated with serum cortisol level was found. Specifically, notable correlations were found in the hippocampus, amygdala, and cerebellum, regions considered to be involved in the regulation and central action of glucocorticoids. Moreover, some hormone-associated regions were found in the frontal and occipital cortex, possibly mediating the cognitive decline seen in Cushing's disease. The findings link patterns of perturbed brain metabolism relates to individual hormone level, thus presenting a substrate for cognitive disturbances seen in Cushing's disease patients, as well as in other conditions with abnormal cortisol levels 1).

1)
Liu S, Wang Y, Xu K, Ping F, Wang R, Li F, Cheng X. Brain glucose metabolism is associated with hormone level in Cushing's disease: A voxel-based study using FDG-PET. Neuroimage Clin. 2016 Aug 24;12:415-9. doi: 10.1016/j.nicl.2016.08.018. eCollection 2016. PubMed PMID: 27622138; PubMed Central PMCID: PMC5008049.
cognitive_disorder.txt · Last modified: 2019/09/03 08:28 by administrador