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Colloid cyst treatment

The treatment of colloid cysts has evolved rapidly since the first successful excision of a colloid cyst via the transcortical transventricular approach by Walter Dandy in 1921 1). This was followed closely by a transcallosal approach by Greenwood in 1949 2).

Surgical resection of recurrent colloid cysts should focus on complete removal of the cyst wall to minimize the chance of recurrence. Microsurgery has been shown to provide the highest success rates for cyst wall resection and lowest rates of recurrence and is therefore recommended for patients undergoing surgery for primary and recurrent colloid cysts 3).

Metaanalysis and systematic review

In a metaanalysis and systematic review microsurgical resection of colloid cysts is associated with a higher rate of complete resection, lower rate of recurrence, and fewer reoperations than with endoscopic removal. However, the rate of morbidity is higher with microsurgery than with endoscopy 4).

An analysis of administrative claims data revealed few differences in surgical complications following colloid cyst excision via microsurgical and endoscopic approaches. Post-operative seizures and thirty-day readmissions were seen at higher frequency in patients who underwent microsurgical resection. Despite similar complication profiles, patients undergoing microsurgical excision experienced higher index admission costs and 90-day aggregated costs suggesting that complications may have been more severe in this group 5).

Incidental colloid cysts are frequently managed with surveillance imaging rather than surgical excision. This approach is born out of their purported indolent growth pattern and the surgical morbidity associated with microsurgical removal. The advent of endoscopic colloid cyst removal may offer renewed assessment of these patients who carry a risk of acute neurological deterioration. An evidence-based recommendation should weigh the risks of operative treatment.

Age and cyst diameter were not correlated with the absence or presence of symptoms in patients with a colloid cyst of the third ventricle. Operative results were highly favorable in both groups and did not reveal a higher risk of morbidity in the patient presenting with an incidental lesion. The results support endoscopic resection as a legitimate therapeutic option for patients with incidental colloid cysts. Generalization of the operative results should be cautiously made, since this is a limited series and the results may depend on the degree of neuroendoscopic experience 6).


Dandy WE. Benign tumors of the third ventricle. In: Thomas CC, editor. Diagnosis and Treatment. Springfield, Baltimore, IL: 1933.
Greenwood J., Jr Paraphysial cysts of the third ventricle; with report of eight cases. J Neurosurg. 1949;6:153–9.
Heller RS, Heilman CB. Colloid Cysts: Evolution of Surgical Approach Preference and Management of Recurrent Cysts. Oper Neurosurg (Hagerstown). 2019 Apr 10. pii: opz059. doi: 10.1093/ons/opz059. [Epub ahead of print] PubMed PMID: 31220314.
Sheikh AB, Mendelson ZS, Liu JK. Endoscopic versus microsurgical resection of colloid cysts: a systematic review and meta-analysis of 1,278 patients. World Neurosurg. 2014 Dec;82(6):1187-97. doi: 10.1016/j.wneu.2014.06.024. Epub 2014 Jun 18. Review. PubMed PMID: 24952223.
Connolly ID, Johnson E, Lamsam L, Veeravagu A, Ratliff J, Li G. Microsurgical vs. Endoscopic Excision of Colloid Cysts: An Analysis of Complications and Costs Using a Longitudinal Administrative Database. Front Neurol. 2017 Jun 9;8:259. doi: 10.3389/fneur.2017.00259. eCollection 2017. PubMed PMID: 28649225; PubMed Central PMCID: PMC5465269.
Margetis K, Christos PJ, Souweidane M. Endoscopic resection of incidental colloid cysts. J Neurosurg. 2014 Jun;120(6):1259-67. doi: 10.3171/2014.3.JNS131289. Epub 2014 Apr 18. PubMed PMID: 24745712.
colloid_cyst_treatment.txt · Last modified: 2019/06/21 16:20 by administrador