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complex_regional_pain_syndrome_treatment

Complex regional pain syndrome treatment

Complex regional pain syndrome treatment is complicated, involving drugs, physical therapy, psychological treatments, and neuromodulation and is usually unsatisfactory, especially if begun late.


Spinal cord stimulation has been proven highly effective in the treatment of Complex Regional Pain Syndrome (CRPS). The definitive implantation of a neurostimulator is usually preceded by a therapeutic test (trial), which has the purpose of identifying whether the patient would respond positively to neuromodulation or not

Case series

From January 2011 to August 2017, 160 patients underwent implantation of spinal cord neurostimulator. Out of that total number of surgeries, 33 patients were unequivocally diagnosed with type 1 Complex Regional Pain Syndrome and selected for this study. The efficacy of the surgical procedure concerning pain improvement was analyzed through the application of the Pain Disability Index and the Visual Analog Pain Scale.

The mean sample age was 48.08 years. The majority of the study subjects were female (66.66%). In respect to the Pain Disability Index, a 65% improvement in disability was observed subsequently to the neurostimulator implantation; in addition, the means of the scores for preoperative and postoperative periods were, respectively, 55 ± 8.69 (p < 0.0001) and 18.90 ± 11.58 (p < 0.0001). Regarding the Visual Analogue Scale, the mean pain in the preoperative period was 9.43 ± 0.77 (p < 0.0001), while the mean in postoperative period was 2.86 ± 2.08 (p < 0.0001). Thus, an average reduction of 70% of painful symptoms was observed after the surgical procedure.

Implantation of a spinal cord neurostimulator presented significant improvement in pain and disability of patients with type 1 CRPS in all cases. These results were obtained following the criteria: 1) patients presenting unequivocal diagnosis of type 1 CRPS; 2) submitted to constant current spinal cord neurostimulator implant; 3) underwent intraoperative tests for precise location of the spinal cord electrode implantation. Therefore, it is possible to suggest that a trial may be unnecessary in that subgroup of patients. Further studies would be required to confirm these findings 1).

1)
Risson EG, Serpa AP, Berger JJ, Koerbel RFH, Koerbel A. Spinal cord stimulation in the treatment of complex regional pain syndrome type 1: Is trial truly required? Clin Neurol Neurosurg. 2018 Jun 10;171:156-162. doi: 10.1016/j.clineuro.2018.06.014. [Epub ahead of print] PubMed PMID: 29913360.
complex_regional_pain_syndrome_treatment.txt · Last modified: 2018/06/19 13:13 by administrador