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contrast_induced_nephropathy

Endovascular coiling procedure for treatment of cerebral aneurysm using contrast media becomes more popular, but the studies about the incidence and risk factors of contrast induced nephropathy (CIN) after coiling procedures are limited. So we evaluated the incidence and risk factors of CIN in patients who undergo cerebral aneurysmal coiling procedures.

METHODS: We retrospectively reviewed electric medical records of patients who underwent cerebral aneurysmal coiling treatments under general anesthesia. CIN was defined as an absolute increase in serum creatinine (≥0.5 mg/dL) or a relative increase (≥25%) in the baseline serum creatinine value at 48-72 h after exposure to a contrast agent.

RESULTS: Elective Cerebral aneurysmal coiling procedures were performed in 230 patients. Of 230 patients, CIN developed in 13 patients (13/230, 5.6%). Underlying diabetes mellitus (30.8% vs. 9.7%, P = 0.040) and patients older than 75 years (30.8% vs. 6.5%, P = 0.012) were risk factors of CIN.

The study demonstrates that the incidence of CIN in patients who underwent elective cerebral aneurysmal coiling procedures is 6.0%. It also identifies potential risk factors like underlying diabetes mellitus and advanced age (≥75 years) 1).


With appropriate management, coil embolization may be safe and effective for intracranial aneurysms in ADPKD. There is a concern about contrast induced nephropathy in patients with CKD stage 5 or high serum Cr level (>2.0 mg/dL) 2).

1)
Joo C, Jung HJ, Park E, Min JW, Kang H, Yoo DS. Contrast induced nephropathy in patients with unruptured cerebral aneurysm after coiling endovascular treatment. World Neurosurg. 2018 Sep 6. pii: S1878-8750(18)31992-2. doi: 10.1016/j.wneu.2018.08.206. [Epub ahead of print] PubMed PMID: 30196168.
2)
Jung SC, Kim CH, Ahn JH, Cho YD, Kang HS, Cho WS, Kim J, Ahn C, Han MH. Endovascular Treatment of Intracranial Aneurysms in Patients With Autosomal Dominant Polycystic Kidney Disease. Neurosurgery. 2015 Oct 21. [Epub ahead of print] PubMed PMID: 26492429.
contrast_induced_nephropathy.txt · Last modified: 2018/09/11 08:52 by administrador