Corticobasal degeneration (CBD) or Corticobasal ganglionic degeneration (CBGD) is a rare, progressive neurodegenerative disease involving the cerebral cortex and the basal ganglia. CBD symptoms typically begin in people from 50–70 years of age,and the average disease duration is six years. It is characterized by marked disorders in movement and cognitive dysfunction, and is classified as one of the Parkinson plus syndromes. Clinical diagnosis is difficult, as symptoms of CBD are often similar to those of other disorders, such as Parkinson's disease (PD), progressive supranuclear palsy (PSP), and Dementia with Lewy bodies (DLB).
Due to the various clinical presentations associated with CBD, a final diagnosis can only be made upon neuropathologic examination. Patients who are suffering from this disorder can learn more about CBD and reach out to others with the same condition for support, through The Foundation for PSP | CBD and Related Brain Diseases, also known as CurePSP.