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cortisol

Cortisol

Cortisol is a steroid hormone, in the glucocorticoid class of hormones, and is produced in humans by the zona fasciculata of the adrenal cortex within the adrenal gland.

The production is 15-25 mg/day.

It is stimulated by ACTH and this stimulated by CRH.

It is released in response to stress and low blood glucose.

It functions to increase blood sugar through gluconeogenesis, to suppress the immune system, and to aid in the metabolism of fat, protein, and carbohydrate. It also decreases bone formation.

Hydrocortisone (INN, USAN, BAN) is a name for cortisol when it is used as a medication. Hydrocortisone is used to treat people who lack adequate naturally generated cortisol.

Remission from Cushing disease (CD) after pituitary adenoma resection may be predicted by a postoperative reduction in serum cortisol level.


Liu et al. retrospectively enrolled 92 consecutive patients with confirmed diagnosis of Cushing's disease. A voxel-based analysis was performed to investigate the association between cerebral 18F positron emission tomography uptake and serum cortisol level. Relatively impaired metabolism of specific brain regions correlated with serum cortisol level was found. Specifically, notable correlations were found in the hippocampus, amygdala, and cerebellum, regions considered to be involved in the regulation and central action of glucocorticoids. Moreover, some hormone-associated regions were found in the frontal lobe cortex and occipital cortex, possibly mediating the cognitive decline seen in Cushing's disease. The findings link patterns of perturbed brain metabolism relates to individual hormone level, thus presenting a substrate for cognitive disturbances seen in Cushing's disease patients, as well as in other conditions with abnormal cortisol levels 1).

1)
Liu S, Wang Y, Xu K, Ping F, Wang R, Li F, Cheng X. Brain glucose metabolism is associated with hormone level in Cushing's disease: A voxel-based study using FDG-PET. Neuroimage Clin. 2016 Aug 24;12:415-9. doi: 10.1016/j.nicl.2016.08.018. eCollection 2016. PubMed PMID: 27622138; PubMed Central PMCID: PMC5008049.
cortisol.txt · Last modified: 2018/01/13 12:06 by administrador