Presence of hydrocephalus, distortion of circle of Willis, and large tumor volume were associated with headache, and the last 2 variables were also associated with more severe and frequent headaches. Radiation treatment and insertion of Ommaya reservoir were associated with reduced headache frequency. In conclusion, headaches are common in patients with craniopharyngioma and are likely related to tumor size and volume. In most patients, headaches improve with successful tumor treatment 1)
CP is frequently diagnosed after long duration of history (DOH), especially in older children. However, DOH was not associated with tumor size, hypothalamic involvement (HI), survival, or functional capacity (FC) 2).
Visual and neurological deficits necessitate rapid diagnostic workup.
A significant number of patients with craniopharyngioma are GH deficient. The safety of GH replacement in these subjects has not been established.
Pascual et al. from the University Hospital La Princesa, Puerta de Hierro University Hospital, Ramón y Cajal University Hospital, Hospital del Sureste, Madrid, Spain. Department of Surgery and Experimental Medicine, University of Ferrara, Italy. Independent Medical Translator, Jenkintown, PA, US. School of Medicine, Technische Universität, Dresden,Germany. Statistics Department, Computing Center, C.S.I.C. Madrid, Spain. investigated a collection of 210 craniopharyngiomas published from 1823 to 2017 providing detailed clinical and pathological information about psychiatric disturbances, and compared the hypothalamic damage in this cohort with the present in a control cohort of 105 cases without psychiatric symptoms.
Psychiatric disorders occurred predominantly in patients with craniopharyngiomas developing primarily at the tuberoinfundibular region (45%) or entirely within the third ventricle (30%), mostly affecting adult patients (61%, p<0.001). Most tumors without psychic symptoms developed beneath the third ventricle floor (53.5%, p<0.001), in young patients (57%, p<0.001). Psychiatric disturbances were classified in six major categories: i) Korsakoff-like memory deficits, 66%; ii) behavior/personality changes, 48.5%; iii) impaired emotional expression/control, 42%; iv) cognitive impairments, 40%; v) mood alterations, 32%; and vi) psychotic symptoms, 22%. None of these was associated with hydrocephalus. Severe memory deficits occurred with damage of the mammillary body (p<0.001). Mood disorders occurred with compression/invasion of the third ventricle floor and/or walls (p<0.012). Coexistence of other hypothalamic symptoms such as temperature/metabolic dysregulation or sleepiness favored the emergence of psychotic disorders (p<0.008). Postoperative psychiatric outcome was better in strictly intraventricular craniopharyngiomas than in other topographies (p<0.001). A multivariate model including the hypothalamic structures involved, age, hydrocephalus and hypothalamic symptoms, predicts the appearance of psychiatric disorders in 81% of patients.