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cyclophilin_a

Cyclophilin A

Cyclophilin A (CypA) is a cytosolic protein that belongs to the peptidyl-prolyl isomerase (PPIase) family and the major intracellular target of the immunosuppressive drug cyclosporin A (CsA).

Increased serum cyclophilin A concentrations could reflect trauma severity and unfavorable outcome after head trauma, substantializing cyclophilin A as a potential biomarker for prognostic prediction of TBI 1).

Cyclophilin A has been found to be involved in many inflammatory diseases via its receptor, cluster of differentiation 147 (CD147).

Cyclophilin A/CD147 interactions may participate in subarachnoid hemorrhage-induced early brain injury via increasing neuronal apoptosis pathway, at least partly through the ERK1/2-nuclear factor-κB pathway. Cyclophilin A/CD147 may be a suitable therapeutic target for subarachnoid hemorrhage 2).

Results provide evidence for the important contribution of CypA as a pertinent component acting through NF-κB-Sox9 in regulation of chondrogenesis signaling. These findings are important to better understand signal-induced chondrogenesis of chondrogenic progenitors in physiological and pathophysiological contexts 3).

1)
Jin HH, Mao TM, Bai ZQ, Chen Y, Ji HL, Jin Y. The 90-day prognostic value of serum cyclophilin A in traumatic brain injury. Clin Chim Acta. 2018 Jun 6. pii: S0009-8981(18)30295-X. doi: 10.1016/j.cca.2018.06.009. [Epub ahead of print] PubMed PMID: 29885319.
2)
Dang B, Li H, Xu X, Shen H, Wang Y, Gao A, He W, Wang Z, Chen G. Cyclophilin A/Cluster of Differentiation 147 Interactions Participate in Early Brain Injury After Subarachnoid Hemorrhage in Rats. Crit Care Med. 2015 Jun 27. [Epub ahead of print] PubMed PMID: 26132882.
3)
Guo M, Shen J, Kwak JH, Choi B, Lee M, Hu S, Zhang X, Ting K, Soo CB, Chiu RH. Novel role for cyclophilin a in regulation of chondrogenic commitment and endochondral ossification. Mol Cell Biol. 2015 Jun 15;35(12):2119-30. doi: 10.1128/MCB.01414-14. Epub 2015 Apr 13. PubMed PMID: 25870110; PubMed Central PMCID: PMC4438250.
cyclophilin_a.txt · Last modified: 2018/06/11 13:06 by administrador