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D-dimer levels indicate venous thromboembolism with a high degree of sensitivity and specificity in patients who have undergone craniotomy.

Previous studies have shown excessive D-dimer level was considered to be a risk factor of thromboembolic disease after spinal surgery 1) 2) 3).

Guo et al found that D-dimer level was closely associated with the development of DVT after craniotomy. The peak plasma D-dimer level occurred on the 3rd day after craniotomy, and the mean plasma D-dimer level gradually decreased from 3 to 14 days after surgery. This phenomena was consistent with the timing of development of DVT, because 65.6% of DVTs were detected within 1 week after surgery; however, whether D-dimer level can be used as an indicator of DVT requires further exploration in future 4).

Si WT, Zhang HG, Sun YB, Bai Y. Correlation analysis on plasma D-dimer level with deep venous thrombosis after spinal surgery. Zhongguo Gu Shang. 2014;27:405–8.
Yoshiiwa T, Miyazaki M, Takita C, Itonaga I, Tsumura H. Analysis of measured D-dimer levels for detection of deep venous thrombosis and pulmonary embolism after spinal surgery. J Spinal Disord Tech. 2011;24:E35–9.
Hamidi S, Riazi M. Cutoff values of plasma d-dimer level in patients with diagnosis of the venous thromboembolism after elective spinal surgery. Asian Spine J. 2015 Apr;9(2):232-8. doi: 10.4184/asj.2015.9.2.232. Epub 2015 Apr 15. PubMed PMID: 25901235; PubMed Central PMCID: PMC4404538.
Guo F, Shashikiran T, Chen X, Yang L, Liu X, Song L. Clinical features and risk factor analysis for lower extremity deep venous thrombosis in Chinese neurosurgical patients. J Neurosci Rural Pract. 2015 Oct-Dec;6(4):471-6. doi: 10.4103/0976-3147.169801. PubMed PMID: 26752303; PubMed Central PMCID: PMC4692000.
d-dimer.txt · Last modified: 2016/06/21 12:42 (external edit)