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deep_brain_stimulation_targets

Globus pallidus internus: Deep brain stimulation (DBS) of the globus pallidus internus (GPi) has been established as an effective and safe treatment for dystonia.

see Pallidal Deep Brain Stimulation

Pedunculopontine nucleus

Subthalamic nucleus

see subthalamic deep brain stimulation

Nucleus basalis of Meynert

Thalamus

Deep brain stimulation of the thalamus (and especially the ventral intermediate nucleus) does not significantly improve a drug-resistant, disabling cerebellar tremor. The dentato-rubro-olivary tract (Guillain-Mollaret triangle, including the red nucleus) is a subcortical loop that is critically involved in tremor genesis.

The red nucleus is a important centre for the genesis of cerebellar tremor and thus a possible target for drug-refractory tremor. Future research must determine how neuromodulation of the red nucleus can best be implemented in patients with cerebellar degeneration 1).

1)
Lefranc M, Manto M, Merle P, Tir M, Montpellier D, Constant JM, Le Gars D, Macron JM, Krystkowiak P. Targeting the Red Nucleus for Cerebellar Tremor. Cerebellum. 2014 Jan 11. [Epub ahead of print] PubMed PMID: 24415178.
deep_brain_stimulation_targets.txt · Last modified: 2019/02/02 14:00 by administrador