Delayed cerebral ischemia

Delayed cerebral ischemia (DCI) is a significant contributor to poor outcomes after aneurysmal subarachnoid hemorrhage (aSAH). Early prediction of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) is essential to prevent infarction.

see Delayed cerebral ischemia etiology.

Delayed cerebral ischemia diagnosis.

see Delayed cerebral ischemia prevention.

Delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (SAH) is an important cause of further morbidity and mortality after an already devastating condition.

Imaging studies to test for the presence of angiographic vasospasm or perfusion deficits in patients with clinical DCI do not seem helpful in selecting which patients should undergo treatment and may not improve outcomes. Future directions include validating these results in prospective cohort studies 1).

The CONSCIOUS-1 trial revealed that clazosentan could not improve mortality or clinical outcome in spite of successful reduction of relative risk in angiographic vasospasm. This result indicates that the pathophysiology underlying DCI is multifactorial and that other pathophysiological factors, which are independent of angiographic vasospasm, can contribute to the outcome. Recent studies have focused on microcirculatory disturbance, such as microthrombosis and arteriolar constriction, as a factor affecting cerebral ischemia after SAH 2).

Delayed cerebral ischemia case series.

Rawal S, Barnett C, John-Baptiste A, Thein HH, Krings T, Rinkel GJ. Effectiveness of diagnostic strategies in suspected delayed cerebral ischemia: a decision analysis. Stroke. 2015 Jan;46(1):77-83. doi: 10.1161/STROKEAHA.114.005916. Epub 2014 Dec 2. PubMed PMID: 25468878.
Naraoka M, Matsuda N, Shimamura N, Asano K, Ohkuma H. The Role of Arterioles and the Microcirculation in the Development of Vasospasm after Aneurysmal SAH. Biomed Res Int. 2014;2014:253746. Epub 2014 May 11. Review. PubMed PMID: 24900959.
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