The dentatorubrothalamic tract (DRTT) is the major efferent cerebellar pathway arising from the dentate nucleus (DN) and decussating to the contralateral red nucleus (RN) and thalamus. Surprisingly, hemispheric cerebellar output influences bilateral limb movements. In animals, uncrossed projections from the DN to the ipsilateral RN and thalamus may explain this phenomenon.
The DN represents an important anatomical structure in surgical interventions involving the posterior fossa, particularly in the elderly due to the common occurrence of atrophy-related problems in this age group. Functionally and anatomically, the DN has close relations with the superior cerebellar peduncle and middle cerebellar peduncle. The inferior cerebellar peduncle poses positional risks, as it follows an anterior and superior course relative to the DN. 1).