Few studies have examined the relationship between diet and Modic changes. Johansen et al. studied the relationship between vitamin D and MC and surprisingly found that MC were more common in individuals with normal levels of vitamin D than in those with low levels. However, the mechanisms underlying the development of MC remain unclear at present. Findings suggest that the link between vitamin D and MC is perhaps related to inflammation, though further confirmatory studies are needed 1).
Individuals with MC are expected to have low levels of vitamin D because of an increased susceptibility to inflammation and/or because microfractures occur in the vertebrae because of increased levels of parathyroid hormone 2) 3).