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The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy.

DUSP1 alleviates cerebral ischemia reperfusion injury via inactivating JNK-Mff pathways and repressing mitochondrial fission.

dusp1.txt · Last modified: 2018/08/24 20:51 by administrador