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Gene amplification is a process that is characterized by an increase in the copy number of a restricted region in a chromosome arm, and is frequently associated with an overexpression of the corresponding amplified gene. Amplified DNA can be organized either as extrachromosomal elements, repeated units at a single locus or scattered throughout the genome. The amplification of the gene for epidermal growth factor receptor (EGFR) is a common finding in glioblastomas and the amplified gene copies appears as double minutes 1).

New pattern of EGFR amplification in glioblastoma and the relationship of gene copy number with gene expression profile Concha Lopez-Gines, Rosario Gil-Benso, Ruben Ferrer-Luna, Rafael Benito, Eva Serna, Jose Gonzalez-Darder, Vicente Quilis, Daniel Monleon, Bernardo Celda & Miguel Cerdá-Nicolas Modern Pathology volume 23, pages 856–865 (2010)
egfr_amplification.txt · Last modified: 2019/05/23 22:25 by administrador