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egfr_amplification

Gene amplification is a process that is characterized by an increase in the copy number of a restricted region in a chromosome arm, and is frequently associated with an overexpression of the corresponding amplified gene. Amplified DNA can be organized either as extrachromosomal elements, repeated units at a single locus or scattered throughout the genome. The amplification of the gene for epidermal growth factor receptor (EGFR) is a common finding in glioblastomas and the amplified gene copies appears as double minutes 1).

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New pattern of EGFR amplification in glioblastoma and the relationship of gene copy number with gene expression profile Concha Lopez-Gines, Rosario Gil-Benso, Ruben Ferrer-Luna, Rafael Benito, Eva Serna, Jose Gonzalez-Darder, Vicente Quilis, Daniel Monleon, Bernardo Celda & Miguel Cerdá-Nicolas Modern Pathology volume 23, pages 856–865 (2010)
egfr_amplification.txt · Last modified: 2019/05/23 22:25 by administrador