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Endodermal sinus tumor (EST)

Also known as yolk sac tumor (YST), is a member of the germ cell tumor group of cancers. It is the most common testicular tumor in children under 3, and is also known as infantile embryonal carcinoma. This age group has a very good prognosis. In contrast to the pure form typical of infants, adult endodermal sinus tumors are often found in combination with other kinds of germ cell tumor, particularly teratoma and embryonal carcinoma. While pure teratoma is usually benign, endodermal sinus tumor is malignant.

The serum alpha fetoprotein level is well correlated with the severity of the tumor. A combination of operation and chemotherapy might be the effective management for EST in the posterior cranial fossa. The prognosis of extragonadal intracranial EST is poor 1).

Gkampeta et al. reported the case of a 3-year-old boy with a primary posterior mediastinal yolk sac tumor who was managed initially with surgery, followed by chemotherapy and had a favorable prognosis. In the literature on yolk sac tumors presenting as a mediastinal mass, pediatric germ cell tumors have been reported very rarely in the posterior mediastinum 2).

Fan MC, Sun P, Lin DL, Yu Y, Yao WC, Feng YG, Tang LM. Primary endodermal sinus tumor in the posterior cranial fossa: clinical analysis of 7 cases. Chin Med Sci J. 2013 Dec;28(4):225-8. PubMed PMID: 24382224.
Gkampeta A, Tziola TS, Tragiannidis A, Papageorgiou T, Spyridakis I, Hatzipantelis E. Primary posterior mediastinal germ cell tumor in a child. Turk Pediatri Ars. 2019 Sep 25;54(3):185-188. doi: 10.14744/TurkPediatriArs.2019.88155. eCollection 2019. PubMed PMID: 31619931; PubMed Central PMCID: PMC6776447.
endodermal_sinus_tumor.txt · Last modified: 2019/11/12 23:39 by administrador