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Endodermal sinus tumor (EST)

Also known as yolk sac tumor (YST), is a member of the germ cell tumor group of cancers. It is the most common testicular tumor in children under 3, and is also known as infantile embryonal carcinoma. This age group has a very good prognosis. In contrast to the pure form typical of infants, adult endodermal sinus tumors are often found in combination with other kinds of germ cell tumor, particularly teratoma and embryonal carcinoma. While pure teratoma is usually benign, endodermal sinus tumor is malignant.

The serum alpha fetoprotein level is well correlated with the severity of the tumor. A combination of operation and chemotherapy might be the effective management for EST in the posterior cranial fossa. The prognosis of extragonadal intracranial EST is poor 1).

Fan MC, Sun P, Lin DL, Yu Y, Yao WC, Feng YG, Tang LM. Primary endodermal sinus tumor in the posterior cranial fossa: clinical analysis of 7 cases. Chin Med Sci J. 2013 Dec;28(4):225-8. PubMed PMID: 24382224.
endodermal_sinus_tumor.txt · Last modified: 2015/04/16 09:53 (external edit)