The epileptogenic zone, defined as the minimum amount of cortex to produce seizure freedom, consists of five conceptual cortical abnormal 'zones': symptomatogenic, irritative, seizure-onset, structurally abnormal (epileptogenic lesion) and functional deficit.

In the 19th century, the so-called “discharging lesion”, defined by the location of the macroscopic cortical lesion and/or clinical ictal semiology, was equivalent to the epileptogenic zone of modern epileptology.

Area of cortex that is necessary and sufficient for initiating seizures and whose removal (or disconnection) is necessary for complete abolition of seizures.


  • epileptogenic_zone.txt
  • Last modified: 2021/06/18 11:31
  • by administrador