Deep brain stimulation (DBS) in thalamic ventrointermediate (VIM) nucleus is the traditional target for the surgical treatment of pharmacologically refractory essential tremor (ET) or parkinsonian tremor.
Deep brain stimulation (DBS) therapy for essential tremor and parkinsonian tremor has proved quite successful.
Patients with ET treated with deep brain stimulation (DBS) with stimulation-induced dysarthria (SID), individualized current-shaping with interleaving stimulation (cs-ILS) reduces dysarthria while maintaining tremor control 1).
Drug-resistant essential tremor (ET) can benefit from open standard stereotactic procedures, such as deep-brain stimulation or radiofrequency thalamotomy. Non-surgical candidates can be offered either high-focused ultrasound (HIFU) or radiosurgery (RS).
All procedures aim to target the same thalamic site, the ventro-intermediate nucleus (e.g., VIM). The mechanisms by which tremor stops after Vim RS or HIFU remain unknown.