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Fatigue is a state of physical and/or mental weakness.

Postoperative fatigue may be considered a symptom of deterioration in cardiovascular function, neuro-muscular performance and nutritional status rather than psychological factors 1).

Fatigue is a major consequence of subarachnoid hemorrhage (SAH), but the specific characteristics are unclear.

The objective of Buunk et al., was to investigate the nature of post-SAH fatigue (mental or physical) and to determine the relationship with functional outcome in the chronic stage. Also, the possible influence of mood disorders and acute SAH-related factors (SAH type and external cerebrospinal fluid (CSF) drainage) on the presence of fatigue was investigated.

Patients with an aneurysmal SAH (aSAH) or angiographically negative SAH (anSAH) were assessed 3 to 10 years post-SAH (N = 221). Questionnaires were used to investigate mental and physical fatigue and mood. Functional outcome was examined with the Glasgow Outcome Scale Extended (GOSE). Between-group comparisons and binary logistic regression analysis were performed.

Frequencies of mental and physical fatigue were 48.4% and 38.5% respectively, with prevalence of mental fatigue being significantly higher. A two-way ANOVA with SAH type and external CSF drainage as independent variables and mental fatigue as dependent variable, showed a significant main effect of CSF drainage only (p < 0.001). Only mental fatigue explained a significant part of the variance in long-term functional outcome (Model χ2 = 52.99, p < 0.001; Nagelkerke R² = 0.32).

Mental fatigue after SAH is a serious burden to the patient and is associated with impaired long-term functional outcome. Distinguishing different aspects of fatigue is relevant as mental post-SAH fatigue might be a target for treatment aimed to improve long-term outcome 2).

Christensen T, Hjortsø NC, Mortensen E, Riis-Hansen M, Kehlet H. Fatigue and anxiety in surgical patients. Acta Psychiatr Scand. 1986 Jan;73(1):76-9. PubMed PMID: 3962706.
Buunk AM, Groen RJM, Wijbenga RA, Ziengs AL, Metzemaekers JDM, van Dijk JMC, Spikman JM. Mental versus physical fatigue after subarachnoid hemorrhage: differential associations with outcome. Eur J Neurol. 2018 Jun 20. doi: 10.1111/ene.13723. [Epub ahead of print] PubMed PMID: 29924481.
fatigue.txt · Last modified: 2018/07/10 18:54 by administrador