Focused ultrasound

see High Intensity focused ultrasound.

Focused ultrasound is a unique noninvasive technique that can transiently disrupt the blood-brain barrier (BBB) and increase accumulation of drugs within targeted areas of the brain.

Arsiwala et al. summarized the current understanding of different types of targeted ultrasound mediated BBB/BTB disruption techniques. We also discuss influence of the tumor microenvironment on BBB opening, as well as the role of immunological response following disruption. Lastly, we highlight the gaps between evaluation of the parameters governing opening of the BBB/BTB. A deeper understanding of physical opening of the BBB/BTB and the biological effects following disruption can potentially enhance treatment strategies for patients with brain tumors 1).

Arsiwala TA, Sprowls SA, Blethen KE, Adkins CE, Saralkar PA, Fladeland RA, Pentz W, Gabriele A, Kielkowski B, Mehta RI, Wang P, Carpenter JS, Ranjan M, Najib U, Rezai AR, Lockman PR. Ultrasound-mediated disruption of the blood tumor barrier for improved therapeutic delivery. Neoplasia. 2021 Jun 14;23(7):676-691. doi: 10.1016/j.neo.2021.04.005. Epub ahead of print. PMID: 34139452.
  • focused_ultrasound.txt
  • Last modified: 2021/06/18 12:25
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