GBA1-associated parkinsonism

It is clear that the immune system and inflammation have a role in Parkinson's disease (PD), including sporadic Parkinson's disease and some genetic forms such as LRRK2-associated Parkinson's disease. One of the most important genes associated with PD is GBA1, as mutations in this gene are found in 5-20% of PD patients in different populations worldwide. Biallelic mutations in GBA1 may cause Gaucher disease, a lysosomal storage disorder with involvement of the immune system, and other lines of evidence link GBA1 to the immune system and inflammation 1).

Al-Azzawi ZAM, Arfaie S, Gan-Or Z. GBA1 and The Immune System: A Potential Role in Parkinson's Disease? J Parkinsons Dis. 2022 Aug 29. doi: 10.3233/JPD-223423. Epub ahead of print. PMID: 36057834.
  • gba1.txt
  • Last modified: 2022/09/05 00:09
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