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glioblastoma_classification

Glioblastoma classification

Glioblastoma IDH Wildtype 9440/3

Giant cell glioblastoma 9441/3

Gliosarcoma 9442/3

Epithelioid glioblastoma 9440/3

Glioblastoma IDH Mutant 9440/3

Glioblastoma NOS.


Glioblastoma (GBM) is also classified as either primary (de novo) or secondary in origin.

see Secondary Glioblastoma.


With the advance of genomics research, there have been a new breakthrough in the molecular classification of gliomas. Glioblastoma (WHO grade Ⅳ) could be subtyped to proneural, neural, classical, and mesenchymal according to the mRNA expression. Low grade gliomas (WHO grade Ⅱ and Ⅲ) could be divided into 5 types using 1p/19q co-deletion, isocitrate dehydrogenase(IDH) mutation, and TERTp (promotor region) mutation. In 2016, a new classification of tumors of the central nervous system was proposed, and some new markers such as IDH1 mutation were introduced into the diagnosis of gliomas. Genotype and phenotype were integrated to diagnose gliomas. In the meantime, precision treatment for gliomas has also been vigorously developed 1).

Glioblastoma multiforme in the motor area.

Cerebellar Glioblastoma Multiforme.

Elderly Glioblastoma.

Pediatric Glioblastoma.

The giant cell glioblastoma is a histological variant of glioblastoma, presenting a prevalence of bizarre, multinucleated (more than 20 nuclei) giant (up to 400 μm diameter) cells.

It is of great importance to seek further subclassifications, biomarkers, and new treatment modalities to make a significant change in survival for individuals 2).

1)
Hua W, Mao Y. [Advance of molecular subtyping and precise treatment for gliomas]. Zhonghua Wai Ke Za Zhi. 2017 Jan 1;55(1):63-66. doi: 10.3760/cma.j.issn.0529-5815.2017.01.016. Chinese. PubMed PMID: 28056258.
2)
Fekete B, Werlenius K, Örndal C, Rydenhag B. Prognostic factors for glioblastoma patients - a clinical population-based study. Acta Neurol Scand. 2016 Jun;133(6):434-41. doi: 10.1111/ane.12481. Epub 2015 Sep 11. PubMed PMID: 26358197.
glioblastoma_classification.txt · Last modified: 2019/06/13 09:05 by administrador