glioblastoma_idh_wildtype

Glioblastoma IDH wildtype

Young adults with isocitrate-dehydrogenase wild-type (IDH-WT) glioblastoma (GBM) represent a rare, understudied population compared to pediatric high grade glioma, IDH-mutant GBM, or IDH-WT GBM in older patients.

Epidermal growth factor receptor copy number gain (EGFR CN gain), is one of the most common genetic alterations in IDH-WT glioma, in young adults with IDH-WT GBM.

High grade gliomas with mutations in the isocitrate dehydrogenase (IDH) gene family confer longer overall survival relative to their IDH wild type

IDH-wildtype = IDH negative = no mutation = poor prognosis.

It appears that IDH mutant gliomas are a distinct disease entity, having a different genetic and epigenetic basis as compared to IDH wild-type (unmutated) gliomas.

The outcome of patients with anaplastic gliomas varies considerably depending on single molecular markers, such as mutations of the isocitrate dehydrogenase (IDH) genes, as well as molecular classifications based on epigenetic or genetic profiles.


Glioblastoma multiforme (GBM) with wildtype isocitrate dehydrogenase (IDH) was the most common malignant tumor in the brain. Almost all gliomas were more prevalent in males, especially in the cluster of WHO grade III gliomas and IDH-wildtype GBM. Age at diagnosis was directly proportional to tumor grade. With respect to the distribution by histology, Jiang et al. found that gliomas concurrent with IDH-mutant and 1p/19q-codeleted or with single IDH-mutant were mainly distributed in frontal lobe, while those with IDH-wildtype were dominant in temporal lobe. Lesions located in insular lobe were more likely to be IDH-mutant astrocytoma. In summary, the results elucidated the epidemiological characteristics as well as the regional constituents of these new gliomas entities, which could bring insights into tumorigenesis and personalized treatment of Chinese glioma population 1).


1)
Jiang H, Cui Y, Wang J, Lin S. Impact of epidemiological characteristics of supratentorial gliomas in adults brought about by the 2016 world health organization classification of tumors of the central nervous system. Oncotarget. 2016 Nov 24. doi: 10.18632/oncotarget.13555. [Epub ahead of print] PubMed PMID: 27888628.
  • glioblastoma_idh_wildtype.txt
  • Last modified: 2019/09/23 19:39
  • by administrador