User Tools

Site Tools


Group-Based Trajectory Modeling

Group-based trajectory models are increasingly being applied in clinical research to map the developmental course of symptoms and assess heterogeneity in response to clinical interventions. In this review, we provide a nontechnical overview of group-based trajectory and growth mixture modeling alongside a sampling of how these models have been applied in clinical research. We discuss the challenges associated with the application of both types of group-based models and propose a set of preliminary guidelines for applied researchers to follow when reporting model results. Future directions in group-based modeling applications are discussed, including the use of trajectory models to facilitate causal inference when random assignment to treatment condition is not possible 1).


2: Chien TY, Lee ML, Wu WL, Ting HW. Exploration of Medical Trajectories of Stroke Patients Based on Group-Based Trajectory Modeling. Int J Environ Res Public Health. 2019 Sep 18;16(18). pii: E3472. doi: 10.3390/ijerph16183472. PubMed PMID: 31540463; PubMed Central PMCID: PMC6765978.

3: Jha RM, Elmer J, Zusman BE, Desai S, Puccio AM, Okonkwo DO, Park SY, Shutter LA, Wallisch JS, Conley YP, Kochanek PM. Intracranial Pressure Trajectories: A Novel Approach to Informing Severe Traumatic Brain Injury Phenotypes. Crit Care Med. 2018 Nov;46(11):1792-1802. doi: 10.1097/CCM.0000000000003361. PubMed PMID: 30119071; PubMed Central PMCID: PMC6185785.

4: Mandelblatt JS, Clapp JD, Luta G, Faul LA, Tallarico MD, McClendon TD, Whitley JA, Cai L, Ahles TA, Stern RA, Jacobsen PB, Small BJ, Pitcher BN, Dura-Fernandis E, Muss HB, Hurria A, Cohen HJ, Isaacs C. Long-term trajectories of self-reported cognitive function in a cohort of older survivors of breast cancer: CALGB 369901 (Alliance). Cancer. 2016 Nov 15;122(22):3555-3563. doi: 10.1002/cncr.30208. Epub 2016 Jul 22. PubMed PMID: 27447359; PubMed Central PMCID: PMC5113662.

5: Elmer J, Gianakas JJ, Rittenberger JC, Baldwin ME, Faro J, Plummer C, Shutter LA, Wassel CL, Callaway CW, Fabio A; Pittsburgh Post-Cardiac Arrest Service. Group-Based Trajectory Modeling of Suppression Ratio After Cardiac Arrest. Neurocrit Care. 2016 Dec;25(3):415-423. PubMed PMID: 27033709; PubMed Central PMCID: PMC5045751.

6: Dudley RW, Parolin M, Gagnon B, Saluja R, Yap R, Montpetit K, Ruck J, Poulin C, Cantin MA, Benaroch TE, Farmer JP. Long-term functional benefits of selective dorsal rhizotomy for spastic cerebral palsy. J Neurosurg Pediatr. 2013 Aug;12(2):142-50. doi: 10.3171/2013.4.PEDS12539. Epub 2013 May 28. PubMed PMID: 23713680.

Nagin DS, Odgers CL. Group-based trajectory modeling in clinical research. Annu Rev Clin Psychol. 2010;6:109-38. doi: 10.1146/annurev.clinpsy.121208.131413. PubMed PMID: 20192788.
group_based_trajectory_modeling.txt · Last modified: 2020/02/14 08:35 by administrador