growth_hormone_deficiency

Growth hormone deficiency

Growth hormone deficiency (GHD), also known as dwarfism or pituitary dwarfism is a condition caused by insufficient amounts of growth hormone in the body.

Individuals surviving cancer and brain tumors may experience growth hormone (GH) deficiency as a result of tumor growth, surgical resection and/or radiotherapy involving the hypothalamic-pituitary region. Given the pro-mitogenic and anti-apoptotic properties of GH and insulin-like growth factor-I, the safety of GH replacement in this population has raised hypothetical safety concerns that have been debated for decades. Data from multicenter studies with extended follow-up have generally not found significant associations between GH replacement and cancer recurrence or mortality from cancer among childhood cancer survivors. Potential associations with secondary neoplasms, especially solid tumors, have been reported, although this risk appears to decline with longer follow-up. Data from survivors of pediatric or adult cancers who are treated with GH during adulthood are scarce, and the risk versus benefit profile of GH replacement of this population remains unclear. Studies pertaining to the safety of GH replacement in individuals treated for nonmalignant brain tumors, including craniopharyngioma and non-functioning pituitary adenoma, have generally been reassuring with regards to the risk of tumor recurrence 1).

Children with GHD have abnormally short stature with normal body proportions.

Growth hormone deficiency diagnosis.

Growth hormone deficiency treatment.

see Growth hormone deficiency after traumatic brain injury.

see Growth hormone deficiency after subarachnoid hemorrhage.


1)
Boguszewski MCS, Cardoso-Demartini AA, Boguszewski CL, Chemaitilly W, Higham CE, Johannsson G, Yuen KCJ. Safety of growth hormone (GH) treatment in GH deficient children and adults treated for cancer and non-malignant intracranial tumors-a review of research and clinical practice. Pituitary. 2021 Jul 25. doi: 10.1007/s11102-021-01173-0. Epub ahead of print. PMID: 34304361.
  • growth_hormone_deficiency.txt
  • Last modified: 2021/07/26 12:28
  • by administrador