homeostasis

Homeostasis

Homeostasis or homoeostasis (homeo- + -stasis) is the property of a system in which variables are regulated so that internal conditions remain stable and relatively constant. Examples of homeostasis include the regulation of temperature and the balance between acidity and alkalinity (pH). It is a process that maintains the stability of the human body's internal environment in response to changes in external conditions.

The concept was described by French physiologist Claude Bernard in 1865 and the word was coined by Walter Bradford Cannon in 1926.

Although the term was originally used to refer to processes within living organisms, it is frequently applied to automatic control systems such as thermostats. Homeostasis requires a sensor to detect changes in the condition to be regulated, an effector mechanism that can vary that condition, and a negative feedback connection between the two.


The cerebral metabolic rate of oxygen consumption (CMRO2) arises from neurons utilizing energy for two functions:

1) maintenance of cell integrity (homeostasis) which normally accounts for ≈ 40% of energy consumption, and 2) conduction of electrical impulses. The occlusion of an artery produces a central core of ischemic tissue where the CMRO2 is not met. The oxygen deficiency precludes aerobic glycolysis and oxidative phosphorylation. ATP production declines and cell homeostasis cannot be maintained, and within minutes irreversible cell death occurs; a so-called cerebral infarction. Surrounding this central core is the penumbra, where collateral flow (usually through leptomeningeal vessels) provides marginal oxygenation which may impair cellular function without immediate irreversible damage. Cells in the penumbra may remain viable for hours.


Energy homeostasis, food intake, and body weight are regulated by specific brain circuits.

Data support the view that arcuate nucleus (ARC) tyrosine hydroxylase (TH) cells play an unrecognized and influential positive role in energy homeostasis 1).


Water homeostasis has been shown crucial for regulation of neuronal excitability. The control of water movement is achieved through a family of small integral membrane channel proteins called aquaporins (AQPs). Despite the fact that changes in water homeostasis occur in sclerotic hippocampi of people with temporal lobe epilepsy (TLE) , the expression of AQPs in the epileptic brain is not fully characterised 2).


1)
Zhang X, van den Pol AN. Hypothalamic arcuate nucleus tyrosine hydroxylase neurons play orexigenic role in energy homeostasis. Nat Neurosci. 2016 Aug 22. doi: 10.1038/nn.4372. [Epub ahead of print] PubMed PMID: 27548245.
2)
Salman MM, Sheilabi MA, Bhattacharyya D, Kitchen P, Conner AC, Bill RM, Woodroofe MN, Conner MT, Princivalle AP. Transcriptome analysis suggests a role for the differential expression of cerebral aquaporins and the MAPK signalling pathway in human temporal lobe epilepsy. Eur J Neurosci. 2017 Jul 17. doi: 10.1111/ejn.13652. [Epub ahead of print] PubMed PMID: 28715131.
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  • Last modified: 2020/07/07 10:37
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