Nonsteroidal antiinflammatory drug.

Theken et al., performed pain phenotyping, functional neuroimaging, pharmacokinetic/pharmacodynamic assessments, inflammation biomarkers, and gene expression profiling in healthy subjects who underwent surgical extraction of bony impacted third molars and were treated with ibuprofen (400 mg; N=19) or placebo (N=10). Analgesic efficacy was not associated with demographic or clinical characteristics, ibuprofen pharmacokinetics, or the degree of cyclooxygenase inhibition by ibuprofen. Compared to partial responders to ibuprofen (N=9, required rescue medication within the dosing interval), complete responders (N=10, no rescue medication) exhibited greater induction of urinary prostaglandin metabolites and serum tumor necrosis factor-α and interleukin-8. Differentially expressed genes in peripheral blood mononuclear cells were enriched for inflammation-related pathways. These findings suggest that a less pronounced activation of the inflammatory prostanoid system is associated with insufficient pain relief on ibuprofen alone and the need for additional therapeutic intervention 1).

Compared to ibuprofen monotherapy, combination of ibuprofen and paracetamol may provide faster and longer analgesia in patients with acute low back pain, with equally favorable effect on mobility and functional ability and similar tolerability 2).

In a matched cohort study of trauma patients, pre injury Ibuprofen use was not associated with progression of initial intracranial hemorrhage and the need for neurosurgical intervention. Preinjury use of Ibuprofen as an independent variable should not warrant the need for a routine repeat head computed tomography (RHCT) scan 3).

2: Yayik AM, Cesur S, Ozturk F, Ahiskalioglu A, Ay AN, Celik EC, Karaavci NC. Postoperative Analgesic Efficacy of the Ultrasound-Guided Erector Spinae Plane Block in Patients Undergoing Lumbar Spinal Decompression Surgery. World Neurosurg. 2019 Mar 7. pii: S1878-8750(19)30572-8. doi: 10.1016/j.wneu.2019.02.149. [Epub ahead of print] PubMed PMID: 30853517.

3: Seliger C, Schaertl J, Gerken M, Luber C, Proescholdt M, Riemenschneider MJ, Leitzmann MF, Hau P, Klinkhammer-Schalke M. Use of statins or NSAIDs and survival of patients with high-grade glioma. PLoS One. 2018 Dec 3;13(12):e0207858. doi: 10.1371/journal.pone.0207858. eCollection 2018. PubMed PMID: 30507932; PubMed Central PMCID: PMC6277074.

4: Nagendrababu V, Pulikkotil SJ, Veettil SK, Teerawattanapong N, Setzer FC. Effect of Nonsteroidal Anti-inflammatory Drug as an Oral Premedication on the Anesthetic Success of Inferior Alveolar Nerve Block in Treatment of Irreversible Pulpitis: A Systematic Review with Meta-analysis and Trial Sequential Analysis. J Endod. 2018 Jun;44(6):914-922.e2. doi: 10.1016/j.joen.2018.02.017. Epub 2018 Apr 27. Review. PubMed PMID: 29709297.

5: Pulikkotil SJ, Nagendrababu V, Veettil SK, Jinatongthai P, Setzer FC. Effect of oral premedication on the anaesthetic efficacy of inferior alveolar nerve block in patients with irreversible pulpitis - A systematic review and network meta-analysis of randomized controlled trials. Int Endod J. 2018 Sep;51(9):989-1004. doi: 10.1111/iej.12912. Epub 2018 Mar 24. PubMed PMID: 29480930.

6: Bidar M, Mortazavi S, Forghani M, Akhlaghi S. Comparison of Effect of Oral Premedication with Ibuprofen or Dexamethasone on Anesthetic Efficacy of Inferior Alveolar Nerve Block in Patients with Irreversible Pulpitis: A Prospective, Randomized, Controlled, Double-blind Study. Bull Tokyo Dent Coll. 2017;58(4):231-236. doi: 10.2209/tdcpublication.2016-0050. PubMed PMID: 29269717.

7: Krohg A, Ullensvang K, Rosseland LA, Langesæter E, Sauter AR. The Analgesic Effect of Ultrasound-Guided Quadratus Lumborum Block After Cesarean Delivery: A Randomized Clinical Trial. Anesth Analg. 2018 Feb;126(2):559-565. doi: 10.1213/ANE.0000000000002648. PubMed PMID: 29135590.

8: Kluonaitis K, Petrauskiene E, Ryliskiene K. Clinical characteristics and overuse patterns of medication overuse headache: Retrospective case-series study. Clin Neurol Neurosurg. 2017 Dec;163:124-127. doi: 10.1016/j.clineuro.2017.10.029. Epub 2017 Oct 31. PubMed PMID: 29101861.

9: Henningsen MJ, Sort R, Møller AM, Herling SF. Peripheral nerve block in ankle fracture surgery: a qualitative study of patients' experiences. Anaesthesia. 2018 Jan;73(1):49-58. doi: 10.1111/anae.14088. Epub 2017 Oct 19. PubMed PMID: 29052225.

10: Soares A, Almeida C, Freitas C, Sales-Sanz M, Ribeiro S. Eyelid Edema: A Rare Cause of a Common Sign. Case Rep Ophthalmol Med. 2017;2017:9193706. doi: 10.1155/2017/9193706. Epub 2017 Aug 7. PubMed PMID: 28848682; PubMed Central PMCID: PMC5564093.

11: Liu S, Pan G, Liu G, Neves JD, Song S, Chen S, Cheng B, Sun Z, Sarmento B, Cui W, Fan C. Electrospun fibrous membranes featuring sustained release of ibuprofen reduce adhesion and improve neurological function following lumbar laminectomy. J Control Release. 2017 Oct 28;264:1-13. doi: 10.1016/j.jconrel.2017.08.011. Epub 2017 Aug 10. PubMed PMID: 28803898.

12: Sort R, Brorson S, Gögenur I, Møller AM. AnAnkle Trial study protocol: a randomised trial comparing pain profiles after peripheral nerve block or spinal anaesthesia for ankle fracture surgery. BMJ Open. 2017 Jun 2;7(5):e016001. doi: 10.1136/bmjopen-2017-016001. PubMed PMID: 28576901; PubMed Central PMCID: PMC5623423.

13: Brignardello-Petersen R. Preoperative oral ibuprofen and oxicam analgesics increase the rate of successful anesthesia of mandibular molars with irreversible pulpitis. J Am Dent Assoc. 2017 May;148(5):e47. doi: 10.1016/j.adaj.2017.02.020. PubMed PMID: 28449751.

14: Xin DL, Hadrévi J, Elliott ME, Amin M, Harris MY, Barr-Gillespie AE, Barbe MF. Effectiveness of conservative interventions for sickness and pain behaviors induced by a high repetition high force upper extremity task. BMC Neurosci. 2017 Mar 29;18(1):36. doi: 10.1186/s12868-017-0354-3. PubMed PMID: 28356066; PubMed Central PMCID: PMC5371184.

15: Stokes AL, Adhikary SD, Quintili A, Puleo FJ, Choi CS, Hollenbeak CS, Messaris E. Liposomal Bupivacaine Use in Transversus Abdominis Plane Blocks Reduces Pain and Postoperative Intravenous Opioid Requirement After Colorectal Surgery. Dis Colon Rectum. 2017 Feb;60(2):170-177. doi: 10.1097/DCR.0000000000000747. PubMed PMID: 28059913.

16: Shantiaee Y, Javaheri S, Movahhedian A, Eslami S, Dianat O. Efficacy of preoperative ibuprofen and meloxicam on the success rate of inferior alveolar nerve block for teeth with irreversible pulpitis. Int Dent J. 2017 Apr;67(2):85-90. doi: 10.1111/idj.12272. Epub 2016 Dec 8. PubMed PMID: 27933616.

17: Bultema K, Fowler S, Drum M, Reader A, Nusstein J, Beck M. Pain Reduction in Untreated Symptomatic Irreversible Pulpitis Using Liposomal Bupivacaine (Exparel): A Prospective, Randomized, Double-blind Trial. J Endod. 2016 Dec;42(12):1707-1712. doi: 10.1016/j.joen.2016.08.018. Epub 2016 Oct 18. PubMed PMID: 27769675.

18: Rajeev A, Tumia N, Karn K, Kashyap S, Mayne D. Postoperative pain relief and functional outcome following total knee arthroplasty - a prospective comparative audit of three analgesic regimes. Acta Orthop Belg. 2016 Aug;82(2):265-270. PubMed PMID: 27682287.

19: Torup H, Hansen EG, Bøgeskov M, Rosenberg J, Mitchell AU, Petersen PL, Mathiesen O, Dahl JB, Møller AM. Transversus abdominis plane block after laparoscopic colonic resection in cancer patients: A randomised clinical trial. Eur J Anaesthesiol. 2016 Oct;33(10):725-30. doi: 10.1097/EJA.0000000000000510. PubMed PMID: 27487909.

20: Park H, Kim EJ, Han J, Han J, Kang D. Effects of analgesics and antidepressants on TREK-2 and TRESK currents. Korean J Physiol Pharmacol. 2016 Jul;20(4):379-85. doi: 10.4196/kjpp.2016.20.4.379. Epub 2016 Jun 23. PubMed PMID: 27382354; PubMed Central PMCID: PMC4930906.

21: LeBlanc BW, Bowary PM, Chao YC, Lii TR, Saab CY. Electroencephalographic signatures of pain and analgesia in rats. Pain. 2016 Oct;157(10):2330-40. doi: 10.1097/j.pain.0000000000000652. PubMed PMID: 27347647.

22: James RF, Kramer DR, Aljuboori ZS, Parikh G, Adams SW, Eaton JC, Abou Al-Shaar H, Badjatia N, Mack WJ, Simard JM. Novel Treatments in Neuroprotection for Aneurysmal Subarachnoid Hemorrhage. Curr Treat Options Neurol. 2016 Aug;18(8):38. doi: 10.1007/s11940-016-0421-6. Review. PubMed PMID: 27325362.

23: Tognù A, Cauli V, de Simone N, Aurini L, Manfrini M, Bonarelli S. In-Plane Ultrasound-Guided Lumbar Plexus Block Using Catheter-Over-Needle Technique in a 14-Month-Old Baby. Reg Anesth Pain Med. 2016 Jul-Aug;41(4):538-41. doi: 10.1097/AAP.0000000000000417. PubMed PMID: 27281724.

24: Okmen K, Dagistan Y, Dagistan E, Kaplan N, Cancan E. Efficacy of the greater occipital nerve block in recurrent migraine type headaches. Neurol Neurochir Pol. 2016;50(3):151-4. doi: 10.1016/j.pjnns.2016.01.015. Epub 2016 Feb 6. PubMed PMID: 27154440.

25: Thybo KH, Schmidt H, Hägi-Pedersen D. Effect of lateral femoral cutaneous nerve-block on pain after total hip arthroplasty: a randomised, blinded, placebo-controlled trial. BMC Anesthesiol. 2016 Mar 23;16:21. doi: 10.1186/s12871-016-0183-4. PubMed PMID: 27006014; PubMed Central PMCID: PMC4804512.

26: Zeiler FA, AlSubaie F, Zeiler K, Bernard F, Skrobik Y. Analgesia in Neurocritical Care: An International Survey and Practice Audit. Crit Care Med. 2016 May;44(5):973-80. doi: 10.1097/CCM.0000000000001602. PubMed PMID: 26983164.

27: Lapidus D, Goldberg J, Hobbs EH, Ram S, Clark GT, Enciso R. Effect of premedication to provide analgesia as a supplement to inferior alveolar nerve block in patients with irreversible pulpitis. J Am Dent Assoc. 2016 Jun;147(6):427-37. doi: 10.1016/j.adaj.2016.01.006. Epub 2016 Mar 4. Review. PubMed PMID: 26952243.

28: Lin CY, Peng HH, Chen MH, Sun JS, Chang CJ, Liu TY, Chen MH. Ibuprofen-conjugated hyaluronate/polygalacturonic acid hydrogel for the prevention of epidural fibrosis. J Biomater Appl. 2016 May;30(10):1589-600. doi: 10.1177/0885328216635838. Epub 2016 Mar 1. PubMed PMID: 26935813.

29: Ghadiri-Sani M, Silver N. Headache (chronic tension-type). BMJ Clin Evid. 2016 Feb 5;2016. pii: 1205. Review. PubMed PMID: 26859719; PubMed Central PMCID: PMC4747324.

30: Akhmadyar NS, Khairulin BE, Amangeldy-Kyzy S, Ospanov MA. Developing drug formularies for the “National Medical Holding” JSC. Int J Risk Saf Med. 2015;27 Suppl 1:S51-2. doi: 10.3233/JRS-150686. PubMed PMID: 26639709.

31: Torup H, Bøgeskov M, Hansen EG, Palle C, Rosenberg J, Mitchell AU, Petersen PL, Mathiesen O, Dahl JB, Møller AM. Transversus abdominis plane (TAP) block after robot-assisted laparoscopic hysterectomy: a randomised clinical trial. Acta Anaesthesiol Scand. 2015 Aug;59(7):928-35. doi: 10.1111/aas.12516. Epub 2015 May 31. PubMed PMID: 26032118.

32: Jaafarpour M, Hatefi M, Khani A, Khajavikhan J. Comparative effect of cinnamon and Ibuprofen for treatment of primary dysmenorrhea: a randomized double-blind clinical trial. J Clin Diagn Res. 2015 Apr;9(4):QC04-7. doi: 10.7860/JCDR/2015/12084.5783. Epub 2015 Apr 1. PubMed PMID: 26023601; PubMed Central PMCID: PMC4437117.

33: Bergese SD, Candiotti K, Ayad SS, Soghomonyan S, Gan TJ; Intravenous Ibuprofen Surveillance Trial Investigational Sites. The shortened infusion time of intravenous ibuprofen part 1: a multicenter, open-label, surveillance trial to evaluate safety and efficacy. Clin Ther. 2015 Feb 1;37(2):360-7. doi: 10.1016/j.clinthera.2014.12.004. Epub 2015 Jan 8. PubMed PMID: 25577542.

34: Riasi H, Rajabpour Sanati A, Salehi F, Salehian H, Ghaemi K. Analyzing the therapeutic effects of short wrist splint in patients with carpal tunnel syndrome (CTS) under ibuprofen treatment from an EMG-NCV perspective. J Med Life. 2015;8(Spec Iss 4):154-158. PubMed PMID: 28316723; PubMed Central PMCID: PMC5319285.

35: Butler TA, Dugan P, French J. Why is mesial temporal lobe epilepsy with Ammon's horn sclerosis becoming less common? Eur J Neurol. 2015 Jan;22(1):e12. doi: 10.1111/ene.12570. PubMed PMID: 25495399.

36: Scott WW, Levy M, Rickert KL, Madden CJ, Beshay JE, Sarode R. Assessment of common nonsteroidal anti-inflammatory medications by whole blood aggregometry: a clinical evaluation for the perioperative setting. World Neurosurg. 2014 Nov;82(5):e633-8. doi: 10.1016/j.wneu.2014.03.043. Epub 2014 Mar 31. PubMed PMID: 24698769.

37: Kim CH, Kadhim S, Julien C. Treatment of pain in SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome. PM R. 2014 Jan;6(1):92-5. doi: 10.1016/j.pmrj.2013.08.610. PubMed PMID: 24439152.

38: Muroi C, Hugelshofer M, Seule M, Keller E. The impact of nonsteroidal anti-inflammatory drugs on inflammatory response after aneurysmal subarachnoid hemorrhage. Neurocrit Care. 2014 Apr;20(2):240-6. doi: 10.1007/s12028-013-9930-2. PubMed PMID: 24233893.

39: Espelund M, Fomsgaard JS, Haraszuk J, Dahl JB, Mathiesen O. The efficacy of adductor canal blockade after minor arthroscopic knee surgery–a randomised controlled trial. Acta Anaesthesiol Scand. 2014 Mar;58(3):273-80. doi: 10.1111/aas.12224. Epub 2013 Nov 8. PubMed PMID: 24205802.

40: Breschan C, Jost R, Stettner H, Feigl G, Semmelrock S, Graf G, Likar R. Ultrasound-guided rectus sheath block for pyloromyotomy in infants: a retrospective analysis of a case series. Paediatr Anaesth. 2013 Dec;23(12):1199-204. doi: 10.1111/pan.12267. Epub 2013 Sep 25. PubMed PMID: 24112798.

41: Nusstein JM. Preoperative oral use of Ibuprofen or dexamethasone may improve the anesthetic efficacy of an inferior alveolar nerve block in patients diagnosed with irreversible pulpitis. J Evid Based Dent Pract. 2013 Sep;13(3):102-3. doi: 10.1016/j.jebdp.2013.07.007. PubMed PMID: 24011005.

42: Noguera-Gonzalez D, Cerda-Cristerna BI, Chavarria-Bolaños D, Flores-Reyes H, Pozos-Guillen A. Efficacy of preoperative ibuprofen on the success of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a randomized clinical trial. Int Endod J. 2013 Nov;46(11):1056-62. doi: 10.1111/iej.12099. Epub 2013 Apr 6. PubMed PMID: 23561002.

43: Espelund M, Fomsgaard JS, Haraszuk J, Mathiesen O, Dahl JB. Analgesic efficacy of ultrasound-guided adductor canal blockade after arthroscopic anterior cruciate ligament reconstruction: a randomised controlled trial. Eur J Anaesthesiol. 2013 Jul;30(7):422-8. doi: 10.1097/EJA.0b013e328360bdb9. PubMed PMID: 23549123.

44: Skjelsager A, Ruhnau B, Kistorp TK, Kridina I, Hvarness H, Mathiesen O, Dahl JB. Transversus abdominis plane block or subcutaneous wound infiltration after open radical prostatectomy: a randomized study. Acta Anaesthesiol Scand. 2013 Apr;57(4):502-8. doi: 10.1111/aas.12080. Epub 2013 Feb 7. PubMed PMID: 23387340.

45: Shahi S, Mokhtari H, Rahimi S, Yavari HR, Narimani S, Abdolrahimi M, Nezafati S. Effect of premedication with ibuprofen and dexamethasone on success rate of inferior alveolar nerve block for teeth with asymptomatic irreversible pulpitis: a randomized clinical trial. J Endod. 2013 Feb;39(2):160-2. doi: 10.1016/j.joen.2012.10.011. Epub 2012 Nov 17. PubMed PMID: 23321224.

46: Dagêstan Y, Karaca I, Bozkurt ER, Bilir A. Effects of Ibuprofen on orthotopic glioma model in rats. J Coll Physicians Surg Pak. 2012 Nov;22(11):690-3. doi: 11.2012/JCPSP.690693. PubMed PMID: 23146847.

47: Jaeger P, Grevstad U, Henningsen MH, Gottschau B, Mathiesen O, Dahl JB. Effect of adductor-canal-blockade on established, severe post-operative pain after total knee arthroplasty: a randomised study. Acta Anaesthesiol Scand. 2012 Sep;56(8):1013-9. doi: 10.1111/j.1399-6576.2012.02737.x. Epub 2012 Jul 26. PubMed PMID: 22834681.

48: Parirokh M, Yosefi MH, Nakhaee N, Manochehrifar H, Abbott PV, Reza Forghani F. Effect of bupivacaine on postoperative pain for inferior alveolar nerve block anesthesia after single-visit root canal treatment in teeth with irreversible pulpitis. J Endod. 2012 Aug;38(8):1035-9. doi: 10.1016/j.joen.2012.04.012. Epub 2012 May 30. PubMed PMID: 22794202.

49: Than KD, Rohatgi P, Wilson TJ, Gregory Thompson B. Perioperative management of a neurosurgical patient requiring antiplatelet therapy. J Clin Neurosci. 2012 Sep;19(9):1316-20. doi: 10.1016/j.jocn.2011.12.018. Epub 2012 Jul 10. PubMed PMID: 22784876.

50: Petersen PL, Stjernholm P, Kristiansen VB, Torup H, Hansen EG, Mitchell AU, Moeller A, Rosenberg J, Dahl JB, Mathiesen O. The beneficial effect of transversus abdominis plane block after laparoscopic cholecystectomy in day-case surgery: a randomized clinical trial. Anesth Analg. 2012 Sep;115(3):527-33. doi: 10.1213/ANE.0b013e318261f16e. Epub 2012 Jul 4. PubMed PMID: 22763903.

51: Li C, Yang X, Ma X, Li L, Shi Z. Preoperative oral nonsteroidal anti-inflammatory drugs for the success of the inferior alveolar nerve block in irreversible pulpitis treatment: a systematic review and meta-analysis based on randomized controlled trials. Quintessence Int. 2012 Mar;43(3):209-19. Review. PubMed PMID: 22299121.

52: Kaviani N, Khademi A, Ebtehaj I, Mohammadi Z. The effect of orally administered ketamine on requirement for anesthetics and postoperative pain in mandibular molar teeth with irreversible pulpitis. J Oral Sci. 2011 Dec;53(4):461-5. PubMed PMID: 22167031.

53: Madura T, Tomita K, Terenghi G. Ibuprofen improves functional outcome after axotomy and immediate repair in the peripheral nervous system. J Plast Reconstr Aesthet Surg. 2011 Dec;64(12):1641-6. doi: 10.1016/j.bjps.2011.07.014. Epub 2011 Aug 3. PubMed PMID: 21813342.

54: Wright EF. Medial pterygoid trismus (myospasm) following inferior alveolar nerve block: case report and literature review. Gen Dent. 2011 Jan-Feb;59(1):64-7. Review. PubMed PMID: 21613042.

55: Mullins ME, Empey M, Jaramillo D, Sosa S, Human T, Diringer MN. A prospective randomized study to evaluate the antipyretic effect of the combination of acetaminophen and ibuprofen in neurological ICU patients. Neurocrit Care. 2011 Dec;15(3):375-8. doi: 10.1007/s12028-011-9533-8. PubMed PMID: 21503807.

56: Simpson M, Drum M, Nusstein J, Reader A, Beck M. Effect of combination of preoperative ibuprofen/acetaminophen on the success of the inferior alveolar nerve block in patients with symptomatic irreversible pulpitis. J Endod. 2011 May;37(5):593-7. doi: 10.1016/j.joen.2011.02.015. Epub 2011 Mar 22. PubMed PMID: 21496654.

57: Farrokhi MR, Alibai E, Maghami Z. Randomized controlled trial of percutaneous vertebroplasty versus optimal medical management for the relief of pain and disability in acute osteoporotic vertebral compression fractures. J Neurosurg Spine. 2011 May;14(5):561-9. doi: 10.3171/2010.12.SPINE10286. Epub 2011 Mar 4. PubMed PMID: 21375382.

58: Teo JH, Palmer GM, Davidson AJ. Post-craniotomy pain in a paediatric population. Anaesth Intensive Care. 2011 Jan;39(1):89-94. PubMed PMID: 21375097.

59: Fredrickson MJ, Paine C, Hamill J. Improved analgesia with the ilioinguinal block compared to the transversus abdominis plane block after pediatric inguinal surgery: a prospective randomized trial. Paediatr Anaesth. 2010 Nov;20(11):1022-7. doi: 10.1111/j.1460-9592.2010.03432.x. PubMed PMID: 20964768.

60: Parirokh M, Ashouri R, Rekabi AR, Nakhaee N, Pardakhti A, Askarifard S, Abbott PV. The effect of premedication with ibuprofen and indomethacin on the success of inferior alveolar nerve block for teeth with irreversible pulpitis. J Endod. 2010 Sep;36(9):1450-4. doi: 10.1016/j.joen.2010.05.007. Epub 2010 Jul 3. PubMed PMID: 20728707.

61: Bauer DF, Waters AM, Tubbs RS, Rozzelle CJ, Wellons JC 3rd, Blount JP, Oakes WJ. Safety and utility of scheduled nonnarcotic analgesic medications in children undergoing craniotomy for brain tumor. Neurosurgery. 2010 Aug;67(2):353-5; discussion 355-6. doi: 10.1227/01.NEU.0000372086.59323.3D. PubMed PMID: 20644421.

62: Martínek J, Hlavova K, Zavada F, Seifert B, Rejchrt S, Urban O, Zavoral M. “A surviving myth”–corticosteroids are still considered ulcerogenic by a majority of physicians. Scand J Gastroenterol. 2010 Oct;45(10):1156-61. doi: 10.3109/00365521.2010.497935. PubMed PMID: 20569095.

63: Oleson M, Drum M, Reader A, Nusstein J, Beck M. Effect of preoperative ibuprofen on the success of the inferior alveolar nerve block in patients with irreversible pulpitis. J Endod. 2010 Mar;36(3):379-82. doi: 10.1016/j.joen.2009.12.030. PubMed PMID: 20171351.

64: Aggarwal V, Singla M, Kabi D. Comparative evaluation of effect of preoperative oral medication of ibuprofen and ketorolac on anesthetic efficacy of inferior alveolar nerve block with lidocaine in patients with irreversible pulpitis: a prospective, double-blind, randomized clinical trial. J Endod. 2010 Mar;36(3):375-8. doi: 10.1016/j.joen.2009.11.010. PubMed PMID: 20171350.

65: Crincoli V, Di Bisceglie MB, Massaro M, Giuliani R, Favia G, Brienza N. Postoperative pain relief after surgical removal of impacted third molars: a single-blind, randomized, controlled study to compare levobupivacaine and mepivacaine. J Orofac Pain. 2009 Fall;23(4):325-9. PubMed PMID: 19888483.

66: Chhabra A, Sinha R, Subramaniam R, Chandra P, Narang D, Garg SP. Comparison of sub-Tenon's block with i.v. fentanyl for paediatric vitreoretinal surgery. Br J Anaesth. 2009 Nov;103(5):739-43. doi: 10.1093/bja/aep230. Epub 2009 Aug 25. PubMed PMID: 19706631.

67: Cui K, Ashdown H, Luheshi GN, Boksa P. Effects of prenatal immune activation on hippocampal neurogenesis in the rat. Schizophr Res. 2009 Sep;113(2-3):288-97. doi: 10.1016/j.schres.2009.05.003. Epub 2009 May 22. PubMed PMID: 19464151.

68: Renner RM, Jensen JT, Nichols MD, Edelman A. Pain control in first trimester surgical abortion. Cochrane Database Syst Rev. 2009 Apr 15;(2):CD006712. doi: 10.1002/14651858.CD006712.pub2. Review. PubMed PMID: 19370649.

69: Lee BS, Yuan X, Xu Q, McLafferty FS, Petersen BA, Collette JC, Black KL, Yu JS. Stimuli-responsive antioxidant nanoprodrugs of NSAIDs. Int J Pharm. 2009 May 8;372(1-2):112-24. doi: 10.1016/j.ijpharm.2008.12.037. Epub 2009 Jan 4. PubMed PMID: 19166922.

70: Wang X, Budel S, Baughman K, Gould G, Song KH, Strittmatter SM. Ibuprofen enhances recovery from spinal cord injury by limiting tissue loss and stimulating axonal growth. J Neurotrauma. 2009 Jan;26(1):81-95. doi: 10.1089/neu.2007.0464. PubMed PMID: 19125588; PubMed Central PMCID: PMC2913782.

71: Omeis I, Neil JA, Murali R, Abrahams JM. Treatment of cerebral vasospasm with biocompatible controlled-release systems for intracranial drug delivery. Neurosurgery. 2008 Dec;63(6):1011-9; discussion 1019-21. doi: 10.1227/01.NEU.0000327574.32000.9A. Erratum in: Neurosurgery. 2009 Apr;64(4):776. Jayson, Neil A [corrected to Neil, Jayson A]. PubMed PMID: 19057314.

72: Fry R, Ring P. Delayed retrobulbar haemorrhage associated with a repeat sub-Tenon's block. Anaesth Intensive Care. 2008 Sep;36(5):752-3. PubMed PMID: 18856008.

73: Radulovic DV, Slavik E, Rakic M. Osteoid osteoma of a cervical vertebral body. Zentralbl Neurochir. 2008 May;69(2):90-2. doi: 10.1055/s-2007-1004586. Epub 2008 Apr 29. PubMed PMID: 18444221.

74: Gucev G, Yasui GM, Chang TY, Lee J. Bilateral ultrasound-guided continuous ilioinguinal-iliohypogastric block for pain relief after cesarean delivery. Anesth Analg. 2008 Apr;106(4):1220-2, table of contents. doi: 10.1213/ane.0b013e3181683821. PubMed PMID: 18349197.

75: Ponde VC. Continuous infraclavicular brachial plexus block: a modified technique to better secure catheter position in infants and children. Anesth Analg. 2008 Jan;106(1):94-6, table of contents. doi: 10.1213/01.ane.0000289633.81407.65. PubMed PMID: 18165560.

76: Ragel BT, Jensen RL, Couldwell WT. Inflammatory response and meningioma tumorigenesis and the effect of cyclooxygenase-2 inhibitors. Neurosurg Focus. 2007;23(4):E7. Review. PubMed PMID: 17961044.

77: Webb D, Guttmann D, Cawley P, Lubowitz JH. Continuous infusion of a local anesthetic versus interscalene block for postoperative pain control after arthroscopic shoulder surgery. Arthroscopy. 2007 Sep;23(9):1006-11. PubMed PMID: 17868841.

78: Tubbs RS, Law C, Davis D, Shoja MM, Acakpo-Satchivi L, Wellons JC 3rd, Blount JP, Oakes WJ. Scheduled oral analgesics and the need for opiates in children following partial dorsal rhizotomy. J Neurosurg. 2007 Jun;106(6 Suppl):439-40. PubMed PMID: 17566399.

79: Ianiro SR, Jeansonne BG, McNeal SF, Eleazer PD. The effect of preoperative acetaminophen or a combination of acetaminophen and Ibuprofen on the success of inferior alveolar nerve block for teeth with irreversible pulpitis. J Endod. 2007 Jan;33(1):11-4. PubMed PMID: 17185119.

80: Gallia GL, Tamargo RJ. Leukocyte-endothelial cell interactions in chronic vasospasm after subarachnoid hemorrhage. Neurol Res. 2006 Oct;28(7):750-8. Review. PubMed PMID: 17164038.

81: Kairaluoma PM, Bachmann MS, Rosenberg PH, Pere PJ. Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery. Anesth Analg. 2006 Sep;103(3):703-8. PubMed PMID: 16931684.

82: Pessini AC, Santos DR, Arantes EC, Souza GE. Mediators involved in the febrile response induced by Tityus serrulatus scorpion venom in rats. Toxicon. 2006 Oct;48(5):556-66. Epub 2006 Jul 7. PubMed PMID: 16911816.

83: Browne KD, Iwata A, Putt ME, Smith DH. Chronic ibuprofen administration worsens cognitive outcome following traumatic brain injury in rats. Exp Neurol. 2006 Oct;201(2):301-7. Epub 2006 Jun 9. PubMed PMID: 16764859.

84: Gille J, Gille M, Gahr R, Wiedemann B. [Acute pain management in proximal femoral fractures: femoral nerve block (catheter technique) vs. systemic pain therapy using a clinic internal organisation model]. Anaesthesist. 2006 Apr;55(4):414-22. German. PubMed PMID: 16320011.

85: Pradilla G, Thai QA, Legnani FG, Clatterbuck RE, Gailloud P, Murphy KP, Tamargo RJ. Local delivery of ibuprofen via controlled-release polymers prevents angiographic vasospasm in a monkey model of subarachnoid hemorrhage. Neurosurgery. 2005 Jul;57(1 Suppl):184-90; discussion 184-90. PubMed PMID: 15987587.

86: Andersen FH, Nielsen K, Kehlet H. Combined ilioinguinal blockade and local infiltration anaesthesia for groin hernia repair–a double-blind randomized study. Br J Anaesth. 2005 Apr;94(4):520-3. Epub 2005 Feb 4. PubMed PMID: 15695545.

87: Reich A, Brinkmann OA. [Regional anesthesia for urologic interventions in the pediatric age group]. Aktuelle Urol. 2004 Sep;35(5):418-25. German. PubMed PMID: 15368132.

88: New P. Cyclooxygenase in the treatment of glioma: its complex role in signal transduction. Cancer Control. 2004 May-Jun;11(3):152-64. Review. PubMed PMID: 15153839.

89: Toivonen J, Permi J, Rosenberg PH. Analgesia and discharge following preincisional ilioinguinal and iliohypogastric nerve block combined with general or spinal anaesthesia for inguinal herniorrhaphy. Acta Anaesthesiol Scand. 2004 Apr;48(4):480-5. PubMed PMID: 15025612.

90: Smyth MD, Banks JT, Tubbs RS, Wellons JC 3rd, Oakes WJ. Efficacy of scheduled nonnarcotic analgesic medications in children after suboccipital craniectomy. J Neurosurg. 2004 Feb;100(2 Suppl Pediatrics):183-6. PubMed PMID: 14758947.

91: Revol P, Gleizal A, Kraft T, Breton P, Freidel M, Bouletreau P. [Brain abscess and diffuse cervico-facial cellulitis: complication after mandibular third molar extraction]. Rev Stomatol Chir Maxillofac. 2003 Oct;104(5):285-9. French. PubMed PMID: 14679348.

92: Antezana DF, Clatterbuck RE, Alkayed NJ, Murphy SJ, Anderson LG, Frazier J, Hurn PD, Traystman RJ, Tamargo RJ. High-dose ibuprofen for reduction of striatal infarcts during middle cerebral artery occlusion in rats. J Neurosurg. 2003 Apr;98(4):860-6. PubMed PMID: 12691413.

93: Foral PA, Wilson AF, Nystrom KK. Gastrointestinal bleeds associated with rofecoxib. Pharmacotherapy. 2002 Mar;22(3):384-6. PubMed PMID: 11898894.

94: Kargar S, Parizi FS. Thoracoscopic sympathectomy in causalgia. Ann Chir Gynaecol. 2001;90(3):193-4. PubMed PMID: 11695793.

95: Casper D, Yaparpalvi U, Rempel N, Werner P. Ibuprofen protects dopaminergic neurons against glutamate toxicity in vitro. Neurosci Lett. 2000 Aug 11;289(3):201-4. PubMed PMID: 10961664.

96: Bokhari A, Pollard BJ. Anaesthesia for assisted conception: a survey of UK practice. Eur J Anaesthesiol. 1999 Apr;16(4):225-30. PubMed PMID: 10234491.

97: Thai QA, Oshiro EM, Tamargo RJ. Inhibition of experimental vasospasm in rats with the periadventitial administration of ibuprofen using controlled-release polymers. Stroke. 1999 Jan;30(1):140-7. PubMed PMID: 9880402.

98: Johnson DC, Chatterjee S. The role of arachidonic acid and/or its metabolites in embryo implantation initiated by epidermal growth factor (EGF). Prostaglandins Leukot Essent Fatty Acids. 1995 Jan;52(1):29-33. PubMed PMID: 7708817.

99: Tobias JD. Pain management of the pediatric patient. Clin Podiatr Med Surg. 1994 Jan;11(1):25-40. Review. PubMed PMID: 8124654.

100: Patel PM, Drummond JC, Sano T, Cole DJ, Kalkman CJ, Yaksh TL. Effect of ibuprofen on regional eicosanoid production and neuronal injury after forebrain ischemia in rats. Brain Res. 1993 Jun 18;614(1-2):315-24. PubMed PMID: 8348324.

101: Bond RF, Krech LH, Hershey JC. Effect of ibuprofen upon denervated skeletal muscle resistance and compliance vessels during endotoxemia. Circ Shock. 1992 Jun;37(2):145-52. PubMed PMID: 1511505.

102: Cornell RP. Central interleukin 1-elicited hyperinsulinemia is mediated by prostaglandins but not autonomics. Am J Physiol. 1989 Oct;257(4 Pt 2):R839-46. PubMed PMID: 2572177.

103: Chyatte D. Prevention of chronic cerebral vasospasm in dogs with ibuprofen and high-dose methylprednisolone. Stroke. 1989 Aug;20(8):1021-6. PubMed PMID: 2756534.

104: Chipkin RE, Chapman RW. Enkephalin heptapeptide (Tyr-Gly-Gly-Phe-Met-Arg-Phe)-induced bronchospasm in guinea pigs: a non-naloxone reversible phenomenon. Life Sci. 1984 May 7;34(19):1809-17. PubMed PMID: 6738293.

105: White RP, Robertson JT. Comparison of piroxicam, meclofenamate, ibuprofen, aspirin, and prostacyclin efficacy in a chronic model of cerebral vasospasm. Neurosurgery. 1983 Jan;12(1):40-6. PubMed PMID: 6338410.

Theken KN, Hersh EV, Lahens NF, Lee HM, Li X, Granquist EJ, Giannakopoulos H, Levin LM, Secreto SA, Grant GR, Detre JA, FitzGerald GA, Grosser T, Farrar JT. Variability in the Analgesic Response to Ibuprofen is Associated with Cyclooxygenase Activation in Inflammatory Pain. Clin Pharmacol Ther. 2019 Mar 31. doi: 10.1002/cpt.1446. [Epub ahead of print] PubMed PMID: 30929268.
Ostojic P, Radunovic G, Lazovic M, Tomanovic-Vujadinovic S. Ibuprofen plus paracetamol versus ibuprofen in acute low back pain: a randomized open label multicenter clinical study. Acta Reumatol Port. 2017 Jan-Mar;42(1):18-25. PubMed PMID: 27978532.
Zangbar B, Pandit V, Rhee P, Khalil M, Kulvatunyou N, O'Keeffe T, Tang A, Gries L, Green DJ, Friese RS, Joseph B. Clinical outcomes in patients on preinjury ibuprofen with traumatic brain injury. Am J Surg. 2014 Aug 1. pii: S0002-9610(14)00366-3. doi: 10.1016/j.amjsurg.2014.05.027. [Epub ahead of print] PubMed PMID: 25190545.
  • ibuprofen.txt
  • Last modified: 2019/04/01 16:58
  • by administrador