ibuprofen

Ibuprofen

Nonsteroidal antiinflammatory drug.


Theken et al., performed pain phenotyping, functional neuroimaging, pharmacokinetic/pharmacodynamic assessments, inflammation biomarkers, and gene expression profiling in healthy subjects who underwent surgical extraction of bony impacted third molars and were treated with ibuprofen (400 mg; N=19) or placebo (N=10). Analgesic efficacy was not associated with demographic or clinical characteristics, ibuprofen pharmacokinetics, or the degree of cyclooxygenase inhibition by ibuprofen. Compared to partial responders to ibuprofen (N=9, required rescue medication within the dosing interval), complete responders (N=10, no rescue medication) exhibited greater induction of urinary prostaglandin metabolites and serum tumor necrosis factor-α and interleukin-8. Differentially expressed genes in peripheral blood mononuclear cells were enriched for inflammation-related pathways. These findings suggest that a less pronounced activation of the inflammatory prostanoid system is associated with insufficient pain relief on ibuprofen alone and the need for additional therapeutic intervention 1).


Compared to ibuprofen monotherapy, combination of ibuprofen and paracetamol may provide faster and longer analgesia in patients with acute low back pain, with equally favorable effect on mobility and functional ability and similar tolerability 2).


In a matched cohort study of trauma patients, pre injury Ibuprofen use was not associated with progression of initial intracranial hemorrhage and the need for neurosurgical intervention. Preinjury use of Ibuprofen as an independent variable should not warrant the need for a routine repeat head computed tomography (RHCT) scan 3).

2: Yayik AM, Cesur S, Ozturk F, Ahiskalioglu A, Ay AN, Celik EC, Karaavci NC. Postoperative Analgesic Efficacy of the Ultrasound-Guided Erector Spinae Plane Block in Patients Undergoing Lumbar Spinal Decompression Surgery. World Neurosurg. 2019 Mar 7. pii: S1878-8750(19)30572-8. doi: 10.1016/j.wneu.2019.02.149. [Epub ahead of print] PubMed PMID: 30853517.

3: Seliger C, Schaertl J, Gerken M, Luber C, Proescholdt M, Riemenschneider MJ, Leitzmann MF, Hau P, Klinkhammer-Schalke M. Use of statins or NSAIDs and survival of patients with high-grade glioma. PLoS One. 2018 Dec 3;13(12):e0207858. doi: 10.1371/journal.pone.0207858. eCollection 2018. PubMed PMID: 30507932; PubMed Central PMCID: PMC6277074.

4: Nagendrababu V, Pulikkotil SJ, Veettil SK, Teerawattanapong N, Setzer FC. Effect of Nonsteroidal Anti-inflammatory Drug as an Oral Premedication on the Anesthetic Success of Inferior Alveolar Nerve Block in Treatment of Irreversible Pulpitis: A Systematic Review with Meta-analysis and Trial Sequential Analysis. J Endod. 2018 Jun;44(6):914-922.e2. doi: 10.1016/j.joen.2018.02.017. Epub 2018 Apr 27. Review. PubMed PMID: 29709297.

5: Pulikkotil SJ, Nagendrababu V, Veettil SK, Jinatongthai P, Setzer FC. Effect of oral premedication on the anaesthetic efficacy of inferior alveolar nerve block in patients with irreversible pulpitis - A systematic review and network meta-analysis of randomized controlled trials. Int Endod J. 2018 Sep;51(9):989-1004. doi: 10.1111/iej.12912. Epub 2018 Mar 24. PubMed PMID: 29480930.

6: Bidar M, Mortazavi S, Forghani M, Akhlaghi S. Comparison of Effect of Oral Premedication with Ibuprofen or Dexamethasone on Anesthetic Efficacy of Inferior Alveolar Nerve Block in Patients with Irreversible Pulpitis: A Prospective, Randomized, Controlled, Double-blind Study. Bull Tokyo Dent Coll. 2017;58(4):231-236. doi: 10.2209/tdcpublication.2016-0050. PubMed PMID: 29269717.

7: Krohg A, Ullensvang K, Rosseland LA, Langesæter E, Sauter AR. The Analgesic Effect of Ultrasound-Guided Quadratus Lumborum Block After Cesarean Delivery: A Randomized Clinical Trial. Anesth Analg. 2018 Feb;126(2):559-565. doi: 10.1213/ANE.0000000000002648. PubMed PMID: 29135590.

8: Kluonaitis K, Petrauskiene E, Ryliskiene K. Clinical characteristics and overuse patterns of medication overuse headache: Retrospective case-series study. Clin Neurol Neurosurg. 2017 Dec;163:124-127. doi: 10.1016/j.clineuro.2017.10.029. Epub 2017 Oct 31. PubMed PMID: 29101861.

9: Henningsen MJ, Sort R, Møller AM, Herling SF. Peripheral nerve block in ankle fracture surgery: a qualitative study of patients' experiences. Anaesthesia. 2018 Jan;73(1):49-58. doi: 10.1111/anae.14088. Epub 2017 Oct 19. PubMed PMID: 29052225.

10: Soares A, Almeida C, Freitas C, Sales-Sanz M, Ribeiro S. Eyelid Edema: A Rare Cause of a Common Sign. Case Rep Ophthalmol Med. 2017;2017:9193706. doi: 10.1155/2017/9193706. Epub 2017 Aug 7. PubMed PMID: 28848682; PubMed Central PMCID: PMC5564093.

11: Liu S, Pan G, Liu G, Neves JD, Song S, Chen S, Cheng B, Sun Z, Sarmento B, Cui W, Fan C. Electrospun fibrous membranes featuring sustained release of ibuprofen reduce adhesion and improve neurological function following lumbar laminectomy. J Control Release. 2017 Oct 28;264:1-13. doi: 10.1016/j.jconrel.2017.08.011. Epub 2017 Aug 10. PubMed PMID: 28803898.

12: Sort R, Brorson S, Gögenur I, Møller AM. AnAnkle Trial study protocol: a randomised trial comparing pain profiles after peripheral nerve block or spinal anaesthesia for ankle fracture surgery. BMJ Open. 2017 Jun 2;7(5):e016001. doi: 10.1136/bmjopen-2017-016001. PubMed PMID: 28576901; PubMed Central PMCID: PMC5623423.

13: Brignardello-Petersen R. Preoperative oral ibuprofen and oxicam analgesics increase the rate of successful anesthesia of mandibular molars with irreversible pulpitis. J Am Dent Assoc. 2017 May;148(5):e47. doi: 10.1016/j.adaj.2017.02.020. PubMed PMID: 28449751.

14: Xin DL, Hadrévi J, Elliott ME, Amin M, Harris MY, Barr-Gillespie AE, Barbe MF. Effectiveness of conservative interventions for sickness and pain behaviors induced by a high repetition high force upper extremity task. BMC Neurosci. 2017 Mar 29;18(1):36. doi: 10.1186/s12868-017-0354-3. PubMed PMID: 28356066; PubMed Central PMCID: PMC5371184.

15: Stokes AL, Adhikary SD, Quintili A, Puleo FJ, Choi CS, Hollenbeak CS, Messaris E. Liposomal Bupivacaine Use in Transversus Abdominis Plane Blocks Reduces Pain and Postoperative Intravenous Opioid Requirement After Colorectal Surgery. Dis Colon Rectum. 2017 Feb;60(2):170-177. doi: 10.1097/DCR.0000000000000747. PubMed PMID: 28059913.

16: Shantiaee Y, Javaheri S, Movahhedian A, Eslami S, Dianat O. Efficacy of preoperative ibuprofen and meloxicam on the success rate of inferior alveolar nerve block for teeth with irreversible pulpitis. Int Dent J. 2017 Apr;67(2):85-90. doi: 10.1111/idj.12272. Epub 2016 Dec 8. PubMed PMID: 27933616.

17: Bultema K, Fowler S, Drum M, Reader A, Nusstein J, Beck M. Pain Reduction in Untreated Symptomatic Irreversible Pulpitis Using Liposomal Bupivacaine (Exparel): A Prospective, Randomized, Double-blind Trial. J Endod. 2016 Dec;42(12):1707-1712. doi: 10.1016/j.joen.2016.08.018. Epub 2016 Oct 18. PubMed PMID: 27769675.

18: Rajeev A, Tumia N, Karn K, Kashyap S, Mayne D. Postoperative pain relief and functional outcome following total knee arthroplasty - a prospective comparative audit of three analgesic regimes. Acta Orthop Belg. 2016 Aug;82(2):265-270. PubMed PMID: 27682287.

19: Torup H, Hansen EG, Bøgeskov M, Rosenberg J, Mitchell AU, Petersen PL, Mathiesen O, Dahl JB, Møller AM. Transversus abdominis plane block after laparoscopic colonic resection in cancer patients: A randomised clinical trial. Eur J Anaesthesiol. 2016 Oct;33(10):725-30. doi: 10.1097/EJA.0000000000000510. PubMed PMID: 27487909.

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25: Thybo KH, Schmidt H, Hägi-Pedersen D. Effect of lateral femoral cutaneous nerve-block on pain after total hip arthroplasty: a randomised, blinded, placebo-controlled trial. BMC Anesthesiol. 2016 Mar 23;16:21. doi: 10.1186/s12871-016-0183-4. PubMed PMID: 27006014; PubMed Central PMCID: PMC4804512.

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28: Lin CY, Peng HH, Chen MH, Sun JS, Chang CJ, Liu TY, Chen MH. Ibuprofen-conjugated hyaluronate/polygalacturonic acid hydrogel for the prevention of epidural fibrosis. J Biomater Appl. 2016 May;30(10):1589-600. doi: 10.1177/0885328216635838. Epub 2016 Mar 1. PubMed PMID: 26935813.

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32: Jaafarpour M, Hatefi M, Khani A, Khajavikhan J. Comparative effect of cinnamon and Ibuprofen for treatment of primary dysmenorrhea: a randomized double-blind clinical trial. J Clin Diagn Res. 2015 Apr;9(4):QC04-7. doi: 10.7860/JCDR/2015/12084.5783. Epub 2015 Apr 1. PubMed PMID: 26023601; PubMed Central PMCID: PMC4437117.

33: Bergese SD, Candiotti K, Ayad SS, Soghomonyan S, Gan TJ; Intravenous Ibuprofen Surveillance Trial Investigational Sites. The shortened infusion time of intravenous ibuprofen part 1: a multicenter, open-label, surveillance trial to evaluate safety and efficacy. Clin Ther. 2015 Feb 1;37(2):360-7. doi: 10.1016/j.clinthera.2014.12.004. Epub 2015 Jan 8. PubMed PMID: 25577542.

34: Riasi H, Rajabpour Sanati A, Salehi F, Salehian H, Ghaemi K. Analyzing the therapeutic effects of short wrist splint in patients with carpal tunnel syndrome (CTS) under ibuprofen treatment from an EMG-NCV perspective. J Med Life. 2015;8(Spec Iss 4):154-158. PubMed PMID: 28316723; PubMed Central PMCID: PMC5319285.

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41: Nusstein JM. Preoperative oral use of Ibuprofen or dexamethasone may improve the anesthetic efficacy of an inferior alveolar nerve block in patients diagnosed with irreversible pulpitis. J Evid Based Dent Pract. 2013 Sep;13(3):102-3. doi: 10.1016/j.jebdp.2013.07.007. PubMed PMID: 24011005.

42: Noguera-Gonzalez D, Cerda-Cristerna BI, Chavarria-Bolaños D, Flores-Reyes H, Pozos-Guillen A. Efficacy of preoperative ibuprofen on the success of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a randomized clinical trial. Int Endod J. 2013 Nov;46(11):1056-62. doi: 10.1111/iej.12099. Epub 2013 Apr 6. PubMed PMID: 23561002.

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Theken KN, Hersh EV, Lahens NF, Lee HM, Li X, Granquist EJ, Giannakopoulos H, Levin LM, Secreto SA, Grant GR, Detre JA, FitzGerald GA, Grosser T, Farrar JT. Variability in the Analgesic Response to Ibuprofen is Associated with Cyclooxygenase Activation in Inflammatory Pain. Clin Pharmacol Ther. 2019 Mar 31. doi: 10.1002/cpt.1446. [Epub ahead of print] PubMed PMID: 30929268.
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Ostojic P, Radunovic G, Lazovic M, Tomanovic-Vujadinovic S. Ibuprofen plus paracetamol versus ibuprofen in acute low back pain: a randomized open label multicenter clinical study. Acta Reumatol Port. 2017 Jan-Mar;42(1):18-25. PubMed PMID: 27978532.
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Zangbar B, Pandit V, Rhee P, Khalil M, Kulvatunyou N, O'Keeffe T, Tang A, Gries L, Green DJ, Friese RS, Joseph B. Clinical outcomes in patients on preinjury ibuprofen with traumatic brain injury. Am J Surg. 2014 Aug 1. pii: S0002-9610(14)00366-3. doi: 10.1016/j.amjsurg.2014.05.027. [Epub ahead of print] PubMed PMID: 25190545.
  • ibuprofen.txt
  • Last modified: 2019/04/01 16:58
  • by administrador