Immunotherapy also called biologic therapy, is a type of cancer treatment that boosts the body's natural defenses to fight cancer. It uses substances made by the body or in a laboratory to improve or restore immune system function.

Several Phase II and III clinical trials have demonstrated that immunotherapy can induce objective responses in otherwise refractory malignancies in tumors outside the central nervous system. In large part, effector T cells mediate much of the antitumor efficacy in these trials, and potent antitumor T cells can be generated through vaccination, immune checkpoint blockade, adoptive cell transfer, and genetic engineering.

The last decades of basic research in virology, oncology, and immunology can be considered a success story. Based on discoveries in these research areas, translational research and clinical studies have changed the way of treatment of cancer by introducing and including immunotherapy 1).

see Cancer Immunotherapy.

The immune reaction during ischemia opens new doors for advanced targeted therapeutics. Nowadays stem cell therapy has shown better results in stroke-prone individuals. Few monoclonal antibodies like natalizumab have shown a great impact on pre-clinical and clinical stroke trial studies 2).

Schirrmacher V, van Gool S, Stuecker W. Counteracting Immunosuppression in the Tumor Microenvironment by Oncolytic Newcastle Disease Virus and Cellular Immunotherapy. Int J Mol Sci. 2022 Oct 27;23(21):13050. doi: 10.3390/ijms232113050. PMID: 36361831.
Chavda V, Madhwani K, Chaurasia B. Stroke and Immunotherapy: Potential Mechanisms and its implications as immune-therapeutics. Eur J Neurosci. 2021 Apr 7. doi: 10.1111/ejn.15224. Epub ahead of print. PMID: 33829590.
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  • Last modified: 2023/01/06 09:09
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