International League Against Epilepsy

ILAE outcome classification

The International League Against Epilepsy (ILAE) was founded in 1909 and is an organization of more than 100 national chapters.

The goals of the ILAE are:

To advance and disseminate knowledge about epilepsy

To promote research, education, and training

To improve services and care for patients, especially by prevention, diagnosis, and treatment.

The International League Against Epilepsy (ILAE) Neuropsychiatry commission and United States Institute of Medicine report both identified cognitive and psychological comorbidities as a significant issue for individuals with epilepsy, with rates as high as 60%. However, there is a paucity of evidence-based treatments for many psychological conditions (e.g., learning disorders, cognitive function disorders, Behavioral problems). Because of inherent challenges in the implementation of psychological therapy trials and specific considerations for the population with epilepsy, the focus of a review was to provide guidance and recommendations to conduct psychological trials for individuals with epilepsy. Several key areas will be discussed, including a selection of patients, trial design, psychological intervention considerations, outcomes and evaluation of results, publication of trial results, and special issues related to pediatric clinical trials. Rigorously designed psychological therapy trials will set the stage for evidence-based practice in the care of individuals with epilepsy, with the goal of improving seizures, side effects, and HRQOL 1).

Modi AC, Wagner J, Smith AW, Kellermann TS, Michaelis R. Implementation of psychological clinical trials in epilepsy: Review and guide. Epilepsy Behav. 2017 Jul 19;74:104-113. doi: 10.1016/j.yebeh.2017.06.016. [Epub ahead of print] Review. PubMed PMID: 28734195.
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