For a given intracranial aneurysm morphology, Cebral et al. 1) showed that intracranial aneurysm hemodynamics do not vary significantly with physiological variations of flow rate, blood pressure, and waveform. Therefore, suitable parameters characterizing IA geometry can capture the characteristic hemodynamics and potentially predict rupture risk. Several past studies have investigated such parameters.
Geometric or intracranial aneurysm hemodynamics considerations favor identification of rupture status; however, retrospective identification of the rupture site remains a challenge for both engineers and clinicians. A more precise understanding of the hemodynamic factors involved in aneurysm wall pathology is likely required for computational fluid dynamics to add value to current clinical decision-making regarding rupture risk 2).
Hemodynamic parameters play a significant role in the development of intracranial aneurysms. Parameters such as wall shear stress (WSS) or velocity could change in time and may contribute to aneurysm growth and rupture. However, the hemodynamic changes at the rupture location remain unclear because it is difficult to obtain data prior to rupture 4).