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Intracranial aneurysm hemodynamics

see also Unruptured intracranial aneurysm rupture risk.

For a given intracranial aneurysm morphology, Cebral et al. 1) showed that intracranial aneurysm hemodynamics do not vary significantly with physiological variations of flow rate, blood pressure, and waveform. Therefore, suitable parameters characterizing IA geometry can capture the characteristic hemodynamics and potentially predict rupture risk. Several past studies have investigated such parameters.

Geometric or intracranial aneurysm hemodynamics considerations favor identification of rupture status; however, retrospective identification of the rupture site remains a challenge for both engineers and clinicians. A more precise understanding of the hemodynamic factors involved in aneurysm wall pathology is likely required for computational fluid dynamics to add value to current clinical decision-making regarding rupture risk 2).

It is known that hemodynamics play an important role in the intracranial aneurysm pathogenesis 3).

Hemodynamic parameters play a significant role in the development of intracranial aneurysms. Parameters such as wall shear stress (WSS) or velocity could change in time and may contribute to aneurysm growth and rupture. However, the hemodynamic changes at the rupture location remain unclear because it is difficult to obtain data prior to rupture 4).

Cebral JR, Castro MA, Appanaboyina S, Putman CM, Millan D, Frangi AF. Efficient pipeline for image-based patient-specific analysis of cerebral aneurysm hemodynamics: Technique and sensitivity. IEEE Trans Med Imaging. 2005;24:457–467.
Janiga G, Berg P, Sugiyama S, Kono K, Steinman DA. The computational fluid dynamics rupture challenge 2013-phase I: prediction of rupture status in intracranial aneurysms. AJNR Am J Neuroradiol. 2015 Mar;36(3):530-6. doi: 10.3174/ajnr.A4157. Epub 2014 Dec 11. PubMed PMID: 25500315.
Cebral JR, Raschi M (2013) Suggested connections between risk factors of intracranial aneurysms: a review. Ann Biomed Eng 41:1366–1383.
Sejkorová A, Dennis KD, Švihlová H, Petr O, Lanzino G, Hejčl A, Dragomir-Daescu D. Hemodynamic changes in a middle cerebral artery aneurysm at follow-up times before and after its rupture: a case report and a review of the literature. Neurosurg Rev. 2016 Nov 24. [Epub ahead of print] PubMed PMID: 27882440.
intracranial_aneurysm_hemodynamics.txt · Last modified: 2019/01/14 11:20 by administrador