Intraoperative radiotherapy

Intraoperative radiotherapy allows direct radiation to the target area while sparing normal surrounding tissue. IORT is used to treat cancers that are difficult to remove during surgery and when there is a concern that microscopic amounts of cancer may remain.

Steininger et al. present preliminary results of IORT in the setting of awake craniotomies. From 2021 to 2022, all patients undergoing awake craniotomies for tumor resection combined with IORT were analyzed retrospectively. Demographical and clinical data, operative procedure, and treatment-related complications were evaluated. Five patients were identified (age (mean ± standard deviation (SD): 65 ± 13.5 years (y)). A solid left frontal metastasis was detected in the first patient (female, 49 y). The second patient (male, 72 y) presented with a solid metastasis on the left parietal lobe. The third patient (male, 52 y) was diagnosed with a left temporoparietal metastasis. Patient four (male, 74 y) was diagnosed with a high-grade glioma on the left frontal lobe. A metastasis on the left temporooccipital lobe was detected in the fifth patient (male, 78 y). After awake craniotomy and macroscopic complete tumor resection, intraoperative tumor bed irradiation was carried out with 50 kV x-rays and a total of 20 Gy for 16.7 ± 2.5 min. During a mean follow-up of 6.3 ± 2.6 months, none of the patients developed any surgery- or IORT-related complications or disabling permanent neurological deficits. Intraoperative radiotherapy in combination with awake craniotomy seems to be feasible and safe. 1).

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Steininger K, Kahl KH, Konietzko I, Wolfert C, Motov S, Krauß PE, Bröcheler T, Hadrawa M, Sommer B, Stüben G, Shiban E. Intraoperative radiotherapy during awake craniotomies: preliminary results of a single-center case series. Neurosurg Rev. 2022 Jul 26. doi: 10.1007/s10143-022-01838-9. Epub ahead of print. PMID: 35881316.
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