joerg_christian_tonn

Jörg Christian Tonn

Date & place of birth: 23.12.1958 in Frankfurt/Main, Germany Scientific career

1977 - 1983 Medical School Justus-Liebig-University, Gießen, Germany 10/1983 Final exam

1983 - 1990 Residency in Neurosurgery, Department of Neurosurgery, University Hospital of Gießen,

Program Directors: Prof. Hans Werner Pia, Prof. Norfried Klug and Prof. Klaus Roosen

02/1990 Board Certification Neurosurgery, Landesärztekammer Hessen, Frankfurt/Main, Germany

1990 Appointment as staff and attending neurosurgeon, Department of Neurosurgery, University-Hospital of Gießen

1991 Attending neurosurgeon, University-Hospital of Würzburg, Germany, Program Director: Prof. K. Roosen

06/1993 Habilitation, University of Würzburg, Medical School

1996 Appointment as Vice-Director of Department, Department of Neurosurgery, University Hospital Würzburg, Germany

1997 Appointment as C3 Professor of Neurosurgery at the Julius-Maximilian-University Würzburg, Germany

2000 Offer as C4 Professor of Neurosurgery at the University of Hamburg, Germany. At the same time also offer as C4 Professor of Neurosurgery at the Department of Neurosurgery, Ludwig-Maximilians-University Munich, Germany

Since 03/2001 Director of the Department of Neurosurgery, University Clinic of Ludwig Maximilians-University Munich-Großhadern


1: Dorfer C, Tonn J, Rutka JT. Ependymoma: a heterogeneous tumor of uncertain origin and limited therapeutic options. Handb Clin Neurol. 2016;134:417-31. doi: 10.1016/B978-0-12-802997-8.00025-6. PubMed PMID: 26948369.

2: Suchorska B, Weller M, Tabatabai G, Senft C, Hau P, Sabel MC, Herrlinger U, Ketter R, Schlegel U, Marosi C, Reifenberger G, Wick W, Tonn JC, Wirsching HG. Complete resection of contrast-enhancing tumor volume is associated with improved survival in recurrent glioblastoma-results from the DIRECTOR trial. Neuro Oncol. 2016 Apr;18(4):549-56. doi: 10.1093/neuonc/nov326. Epub 2016 Jan 27. PubMed PMID: 26823503; PubMed Central PMCID: PMC4799687.

3: Suchorska B, Albert NL, Tonn JC. Usefulness of PET Imaging to Guide Treatment Options in Gliomas. Curr Treat Options Neurol. 2016 Jan;18(1):4. doi: 10.1007/s11940-015-0384-z. PubMed PMID: 26815310.

4: Kunz M, Nachbichler SB, Ertl L, Fesl G, Egensperger R, Niyazi M, Schmid I, Tonn JC, Peraud A, Kreth FW. Early treatment of complex located pediatric low-grade gliomas using iodine-125 brachytherapy alone or in combination with microsurgery. Cancer Med. 2016 Mar;5(3):442-53. doi: 10.1002/cam4.605. Epub 2015 Dec 29. PubMed PMID: 26714663; PubMed Central PMCID: PMC4799958.

5: Albert NL, Winkelmann I, Suchorska B, Wenter V, Schmid-Tannwald C, Mille E, Todica A, Brendel M, Tonn JC, Bartenstein P, la Fougère C. Early static (18)F-FET-PET scans have a higher accuracy for glioma grading than the standard 20-40 min scans. Eur J Nucl Med Mol Imaging. 2015 Dec 15. [Epub ahead of print] PubMed PMID: 26666239.

6: Terpolilli NA, Rachinger W, Kunz M, Thon N, Flatz WH, Tonn JC, Schichor C. Orbit-associated tumors: navigation and control of resection using intraoperative computed tomography. J Neurosurg. 2015 Nov 13:1-9. [Epub ahead of print] PubMed PMID: 26566206.

7: Bordag N, Klie S, Jürchott K, Vierheller J, Schiewe H, Albrecht V, Tonn JC, Schwartz C, Schichor C, Selbig J. Glucocorticoid (dexamethasone)-induced metabolome changes in healthy males suggest prediction of response and side effects. Sci Rep. 2015 Nov 3;5:15954. doi: 10.1038/srep15954. PubMed PMID: 26526738; PubMed Central PMCID: PMC4630650.

8: Thon N, Kreth FW, Tonn JC. The role of surgery in grade II/III oligodendroglial tumors. CNS Oncol. 2015;4(5):317-23. doi: 10.2217/cns.15.26. Epub 2015 Oct 19. PubMed PMID: 26478133.

9: Albrecht V, Richter A, Pfeiffer S, Gebauer M, Lindner S, Gieser E, Schüller U, Schichor C, Gildehaus FJ, Bartenstein P, Tonn JC, Skerra A, Glass R. Anticalins directed against the fibronectin extra domain B as diagnostic tracers for glioblastomas. Int J Cancer. 2016 Mar 1;138(5):1269-80. doi: 10.1002/ijc.29874. Epub 2015 Oct 15. PubMed PMID: 26421425.

10: Lutz J, Thon N, Stahl R, Lummel N, Tonn JC, Linn J, Mehrkens JH. Microstructural alterations in trigeminal neuralgia determined by diffusion tensor imaging are independent of symptom duration, severity, and type of neurovascular conflict. J Neurosurg. 2016 Mar;124(3):823-30. doi: 10.3171/2015.2.JNS142587. Epub 2015 Sep 25. PubMed PMID: 26406792.

11: Stoecklein VM, Lummel N, Ertl L, Kunz M, Tonn JC, Mueller S. Pediatric Giant Cell Glioblastoma Mimicking Hemorrhage Secondary to Ischemic Stroke. Pediatr Neurol. 2015 Nov;53(5):459-61. doi: 10.1016/j.pediatrneurol.2015.08.002. Epub 2015 Aug 8. PubMed PMID: 26344331.

12: Grau SJ, Trillsch F, Tonn JC, Goldbrunner RH, Noessner E, Nelson PJ, von Luettichau I. Podoplanin increases migration and angiogenesis in malignant glioma. Int J Clin Exp Pathol. 2015 Jul 1;8(7):8663-70. eCollection 2015. PubMed PMID: 26339454; PubMed Central PMCID: PMC4555782.

13: Schwartz C, Romagna A, Thon N, Niyazi M, Watson J, Belka C, Tonn JC, Kreth FW, Nachbichler SB. Outcome and toxicity profile of salvage low-dose-rate iodine-125 stereotactic brachytherapy in recurrent high-grade gliomas. Acta Neurochir (Wien). 2015 Oct;157(10):1757-64; discussion 1764. doi: 10.1007/s00701-015-2550-1. Epub 2015 Aug 23. PubMed PMID: 26298594.

14: Stoecklein VM, Faber F, Koch M, Mattmüller R, Schaper A, Rudolph F, Tonn JC, Schichor C. Optional real-time display of intraoperative neurophysiological monitoring in the microscopic field of view: avoiding communication failures in the operating room. Acta Neurochir (Wien). 2015 Nov;157(11):1843-7. doi: 10.1007/s00701-015-2518-1. Epub 2015 Aug 5. PubMed PMID: 26239252.

15: Romagna A, Rachinger W, Schwartz C, Mehrkens JH, Betz C, Briegel J, Schnell O, Tonn JC, Schichor C, Thon N. Endotracheal Tube Electrodes to Assess Vocal Cord Motor Function During Surgery in the Cerebellopontine Angle. Neurosurgery. 2015 Sep;77(3):471-8; discussion 478. doi: 10.1227/NEU.0000000000000854. PubMed PMID: 26103443.

16: Mock A, Warta R, Geisenberger C, Bischoff R, Schulte A, Lamszus K, Stadler V, Felgenhauer T, Schichor C, Schwartz C, Matschke J, Jungk C, Ahmadi R, Sahm F, Capper D, Glass R, Tonn JC, Westphal M, von Deimling A, Unterberg A, Bermejo JL, Herold-Mende C. Printed peptide arrays identify prognostic TNC serumantibodies in glioblastoma patients. Oncotarget. 2015 May 30;6(15):13579-90. PubMed PMID: 25944688; PubMed Central PMCID: PMC4537035.

17: Suchorska B, Kunz M, Schniepp R, Jahn K, Goetz C, Tonn JC, Peraud A. Optimized surgical treatment for normal pressure hydrocephalus: comparison between gravitational and differential pressure valves. Acta Neurochir (Wien). 2015 Apr;157(4):703-9. doi: 10.1007/s00701-015-2345-4. Epub 2015 Feb 11. PubMed PMID: 25666108.

18: Weller M, Tabatabai G, Kästner B, Felsberg J, Steinbach JP, Wick A, Schnell O, Hau P, Herrlinger U, Sabel MC, Wirsching HG, Ketter R, Bähr O, Platten M, Tonn JC, Schlegel U, Marosi C, Goldbrunner R, Stupp R, Homicsko K, Pichler J, Nikkhah G, Meixensberger J, Vajkoczy P, Kollias S, Hüsing J, Reifenberger G, Wick W; DIRECTOR Study Group. MGMT Promoter Methylation Is a Strong Prognostic Biomarker for Benefit from Dose-Intensified Temozolomide Rechallenge in Progressive Glioblastoma: The DIRECTOR Trial. Clin Cancer Res. 2015 May 1;21(9):2057-64. doi: 10.1158/1078-0432.CCR-14-2737. Epub 2015 Feb 5. PubMed PMID: 25655102.

19: Rachinger W, Stoecklein VM, Terpolilli NA, Haug AR, Ertl L, Pöschl J, Schüller U, Schichor C, Thon N, Tonn JC. Increased 68Ga-DOTATATE uptake in PET imaging discriminates meningioma and tumor-free tissue. J Nucl Med. 2015 Mar;56(3):347-53. doi: 10.2967/jnumed.114.149120. Epub 2015 Jan 29. PubMed PMID: 25635133.

20: Suchorska B, Jansen NL, Linn J, Kretzschmar H, Janssen H, Eigenbrod S, Simon M, Pöpperl G, Kreth FW, la Fougere C, Weller M, Tonn JC; German Glioma Network. Biological tumor volume in 18FET-PET before radiochemotherapy correlates with survival in GBM. Neurology. 2015 Feb 17;84(7):710-9. doi: 10.1212/WNL.0000000000001262. Epub 2015 Jan 21. PubMed PMID: 25609769.

21: Jansen NL, Suchorska B, Wenter V, Schmid-Tannwald C, Todica A, Eigenbrod S, Niyazi M, Tonn JC, Bartenstein P, Kreth FW, la Fougère C. Prognostic significance of dynamic 18F-FET PET in newly diagnosed astrocytic high-grade glioma. J Nucl Med. 2015 Jan;56(1):9-15. doi: 10.2967/jnumed.114.144675. PubMed PMID: 25537990.

22: Suchorska B, Tonn JC, Jansen NL. PET imaging for brain tumor diagnostics. Curr Opin Neurol. 2014 Dec;27(6):683-8. doi: 10.1097/WCO.0000000000000143. Review. PubMed PMID: 25333605.

23: Thon N, Kunz M, Lemke L, Jansen NL, Eigenbrod S, Kreth S, Lutz J, Egensperger R, Giese A, Herms J, Weller M, Kretzschmar H, Tonn JC, la Fougère C, Kreth FW. Dynamic 18F-FET PET in suspected WHO grade II gliomas defines distinct biological subgroups with different clinical courses. Int J Cancer. 2015 May 1;136(9):2132-45. doi: 10.1002/ijc.29259. Epub 2014 Nov 3. PubMed PMID: 25311315.

24: Stupp R, Hegi ME, Gorlia T, Erridge SC, Perry J, Hong YK, Aldape KD, Lhermitte B, Pietsch T, Grujicic D, Steinbach JP, Wick W, Tarnawski R, Nam DH, Hau P, Weyerbrock A, Taphoorn MJ, Shen CC, Rao N, Thurzo L, Herrlinger U, Gupta T, Kortmann RD, Adamska K, McBain C, Brandes AA, Tonn JC, Schnell O, Wiegel T, Kim CY, Nabors LB, Reardon DA, van den Bent MJ, Hicking C, Markivskyy A, Picard M, Weller M; European Organisation for Research and Treatment of Cancer (EORTC); Canadian Brain Tumor Consortium; CENTRIC study team. Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol. 2014 Sep;15(10):1100-8. doi: 10.1016/S1470-2045(14)70379-1. Epub 2014 Aug 19. PubMed PMID: 25163906.

25: Weller M, van den Bent M, Hopkins K, Tonn JC, Stupp R, Falini A, Cohen-Jonathan-Moyal E, Frappaz D, Henriksson R, Balana C, Chinot O, Ram Z, Reifenberger G, Soffietti R, Wick W; European Association for Neuro-Oncology (EANO) Task Force on Malignant Glioma. EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma. Lancet Oncol. 2014 Aug;15(9):e395-403. doi: 10.1016/S1470-2045(14)70011-7. Erratum in: Lancet Oncol. 2014 Dec;15(13):e587. PubMed PMID: 25079102.

26: Keunen O, Taxt T, Grüner R, Lund-Johansen M, Tonn JC, Pavlin T, Bjerkvig R, Niclou SP, Thorsen F. Multimodal imaging of gliomas in the context of evolving cellular and molecular therapies. Adv Drug Deliv Rev. 2014 Sep 30;76:98-115. doi: 10.1016/j.addr.2014.07.010. Epub 2014 Jul 28. Review. PubMed PMID: 25078721.

27: Wowra B, Muacevic A, Jess-Hempen A, Hempel JM, Müller-Schunk S, Tonn JC. Outpatient Gamma knife radiosurgery for vestibular schwannoma: definition of the therapeutic profile based on a 10-year experience. J Neurosurg. 2013 Dec;119 Suppl:114-8. PubMed PMID: 25077312.

28: Schwartz C, Lutz J, Romagna A, Tonn JC, Zausinger S, Schöller K. Microsurgical fenestration of idiopathic intramedullary cysts in adult patients. Eur Spine J. 2015 May;24(5):968-74. doi: 10.1007/s00586-014-3437-1. Epub 2014 Jun 29. PubMed PMID: 24972982.

29: Eigenbrod S, Trabold R, Brucker D, Erös C, Egensperger R, La Fougere C, Göbel W, Rühm A, Kretzschmar HA, Tonn JC, Herms J, Giese A, Kreth FW. Molecular stereotactic biopsy technique improves diagnostic accuracy and enables personalized treatment strategies in glioma patients. Acta Neurochir (Wien). 2014 Aug;156(8):1427-40. doi: 10.1007/s00701-014-2073-1. Epub 2014 May 3. PubMed PMID: 24792966.

30: Stupp R, Brada M, van den Bent MJ, Tonn JC, Pentheroudakis G; ESMO Guidelines Working Group. High-grade glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2014 Sep;25 Suppl 3:iii93-101. doi: 10.1093/annonc/mdu050. Epub 2014 Apr 29. PubMed PMID: 24782454.

31: Guo KT, Fu P, Juerchott K, Motaln H, Selbig J, Lah T, Tonn JC, Schichor C. The expression of Wnt-inhibitor DKK1 (Dickkopf 1) is determined by intercellular crosstalk and hypoxia in human malignant gliomas. J Cancer Res Clin Oncol. 2014 Aug;140(8):1261-70. doi: 10.1007/s00432-014-1642-2. Epub 2014 Apr 27. PubMed PMID: 24770633.

32: Rachinger W, Eigenbrod S, Dützmann S, Simon M, Feigl GC, Kremenevskaja N, Kretzschmar H, Zausinger S, Kreth FW, Thon N, Tonn JC. Male sex as a risk factor for the clinical course of skull base chordomas. J Neurosurg. 2014 Jun;120(6):1313-20. doi: 10.3171/2013.11.JNS131137. Epub 2014 Jan 3. PubMed PMID: 24405075.

33: Stummer W, Tonn JC, Goetz C, Ullrich W, Stepp H, Bink A, Pietsch T, Pichlmeier U. 5-Aminolevulinic acid-derived tumor fluorescence: the diagnostic accuracy of visible fluorescence qualities as corroborated by spectrometry and histology and postoperative imaging. Neurosurgery. 2014 Mar;74(3):310-9; discussion 319-20. doi: 10.1227/NEU.0000000000000267. PubMed PMID: 24335821; PubMed Central PMCID: PMC4206350.

34: Kreth FW, Thon N, Simon M, Westphal M, Schackert G, Nikkhah G, Hentschel B, Reifenberger G, Pietsch T, Weller M, Tonn JC; German Glioma Network. Gross total but not incomplete resection of glioblastoma prolongs survival in the era of radiochemotherapy. Ann Oncol. 2013 Dec;24(12):3117-23. doi: 10.1093/annonc/mdt388. Epub 2013 Oct 14. PubMed PMID: 24130262.

35: Schwartz C, Grillhösl A, Schichor C, Suchorska B, Romagna A, Tonn JC, Zausinger S. Symptomatic cavernous malformations of the brainstem: functional outcome after microsurgical resection. J Neurol. 2013 Nov;260(11):2815-22. doi: 10.1007/s00415-013-7071-3. Epub 2013 Aug 22. PubMed PMID: 23974645.

36: Hartmann C, Hentschel B, Simon M, Westphal M, Schackert G, Tonn JC, Loeffler M, Reifenberger G, Pietsch T, von Deimling A, Weller M; German Glioma Network. Long-term survival in primary glioblastoma with versus without isocitrate dehydrogenase mutations. Clin Cancer Res. 2013 Sep 15;19(18):5146-57. doi: 10.1158/1078-0432.CCR-13-0017. Epub 2013 Aug 5. PubMed PMID: 23918605.

37: Romagna A, Suchorska B, Schwartz C, Tonn JC, Zausinger S. Detethering of a congenital tethered cord in adult patients: an outcome analysis. Acta Neurochir (Wien). 2013 May;155(5):793-800. doi: 10.1007/s00701-013-1652-x. Epub 2013 Mar 8. PubMed PMID: 23471599.

38: Combs SE, Ganswindt U, Foote RL, Kondziolka D, Tonn JC. State-of-the-art treatment alternatives for base of skull meningiomas: complementing and controversial indications for neurosurgery, stereotactic and robotic based radiosurgery or modern fractionated radiation techniques. Radiat Oncol. 2012 Dec 29;7:226. doi: 10.1186/1748-717X-7-226. Review. PubMed PMID: 23273161; PubMed Central PMCID: PMC3551826.

39: Kunz M, Bakhshai Y, Zausinger S, Fesl G, Janssen H, Brückmann H, Tonn JC, Schichor C. Interdisciplinary treatment of unruptured intracranial aneurysms: impact of intraprocedural rupture and ischemia in 563 aneurysms. J Neurol. 2013 May;260(5):1304-13. doi: 10.1007/s00415-012-6795-9. Epub 2012 Dec 23. PubMed PMID: 23263594.

40: Schöller K, Massmann M, Markl G, Kunz M, Fesl G, Brückmann H, Pfefferkorn T, Tonn JC, Schichor C. Aneurysmal subarachnoid hemorrhage in elderly patients: long-term outcome and prognostic factors in an interdisciplinary treatment approach. J Neurol. 2013 Apr;260(4):1052-60. doi: 10.1007/s00415-012-6758-1. Epub 2012 Dec 6. PubMed PMID: 23224052.

41: Guo KT, Juerchott K, Fu P, Selbig J, Eigenbrod S, Tonn JC, Schichor C. Isolation and characterization of bone marrow-derived progenitor cells from malignant gliomas. Anticancer Res. 2012 Nov;32(11):4971-82. PubMed PMID: 23155267.

42: Tonn JC, Thon N, Schnell O, Kreth FW. Personalized surgical therapy. Ann Oncol. 2012 Sep;23 Suppl 10:x28-32. PubMed PMID: 22987977.

43: Armbruster L, Kunz M, Ertl-Wagner B, Tonn JC, Peraud A. Microsurgical outlet restoration in isolated fourth ventricular hydrocephalus: a single-institutional experience. Childs Nerv Syst. 2012 Dec;28(12):2101-7. doi: 10.1007/s00381-012-1887-5. Epub 2012 Aug 16. PubMed PMID: 22895679.

44: Schnell O, Morhard D, Holtmannspötter M, Reiser M, Tonn JC, Schichor C. Near-infrared indocyanine green videoangiography (ICGVA) and intraoperative computed tomography (iCT): are they complementary or competitive imaging techniques in aneurysm surgery? Acta Neurochir (Wien). 2012 Oct;154(10):1861-8. doi: 10.1007/s00701-012-1386-1. Epub 2012 Jul 13. PubMed PMID: 22790837.

45: Wowra B, Muacevic A, Fürweger C, Schichor C, Tonn JC. Therapeutic profile of single-fraction radiosurgery of vestibular schwannoma: unrelated malignancy predicts tumor control. Neuro Oncol. 2012 Jul;14(7):902-9. doi: 10.1093/neuonc/nos085. Epub 2012 May 3. PubMed PMID: 22561798; PubMed Central PMCID: PMC3379795.

46: Leske H, Haase R, Restle F, Schichor C, Albrecht V, Vizoso Pinto MG, Tonn JC, Baiker A, Thon N. Varicella zoster virus infection of malignant glioma cell cultures: a new candidate for oncolytic virotherapy? Anticancer Res. 2012 Apr;32(4):1137-44. PubMed PMID: 22493342.

47: Schnell O, Romagna A, Jaehnert I, Albrecht V, Eigenbrod S, Juerchott K, Kretzschmar H, Tonn JC, Schichor C. Krüppel-like factor 8 (KLF8) is expressed in gliomas of different WHO grades and is essential for tumor cell proliferation. PLoS One. 2012;7(1):e30429. doi: 10.1371/journal.pone.0030429. Epub 2012 Jan 19. PubMed PMID: 22276196; PubMed Central PMCID: PMC3261906.

48: Wowra B, Muacevic A, Tonn JC. CyberKnife radiosurgery for brain metastases. Prog Neurol Surg. 2012;25:201-9. doi: 10.1159/000331193. Epub 2012 Jan 6. Review. PubMed PMID: 22236681.

49: Kufeld M, Wowra B, Muacevic A, Zausinger S, Tonn JC. Radiosurgery of spinal meningiomas and schwannomas. Technol Cancer Res Treat. 2012 Feb;11(1):27-34. PubMed PMID: 22181328; PubMed Central PMCID: PMC4527413.

50: Kreth FW, Thon N, Tonn JC. Low-grade gliomas. J Neurosurg. 2012 Feb;116(2):468-70; author reply 469-70. doi: 10.3171/2011.3.JNS11486. Epub 2011 Nov 25. PubMed PMID: 22117182.

51: Faber F, Thon N, Fesl G, Rachinger W, Guckler R, Tonn JC, Schichor C. Enhanced analysis of intracerebral arterioveneous malformations by the intraoperative use of analytical indocyanine green videoangiography: technical note. Acta Neurochir (Wien). 2011 Nov;153(11):2181-7. doi: 10.1007/s00701-011-1141-z. Epub 2011 Sep 6. PubMed PMID: 21894496.

52: Thon N, Eigenbrod S, Kreth S, Lutz J, Tonn JC, Kretzschmar H, Peraud A, Kreth FW. IDH1 mutations in grade II astrocytomas are associated with unfavorable progression-free survival and prolonged postrecurrence survival. Cancer. 2012 Jan 15;118(2):452-60. doi: 10.1002/cncr.26298. Epub 2011 Jun 29. PubMed PMID: 21717448.

53: Grau S, Schueller U, Weiss C, Tonn JC. Primary meningeal T-cell lymphoma at the clivus mimicking a meningioma. World Neurosurg. 2010 Oct-Nov;74(4-5):513-6. doi: 10.1016/j.wneu.2010.06.020. Epub 2011 Jan 12. PubMed PMID: 21492604.

54: Reardon DA, Neyns B, Weller M, Tonn JC, Nabors LB, Stupp R. Cilengitide: an RGD pentapeptide ανβ3 and ανβ5 integrin inhibitor in development for glioblastoma and other malignancies. Future Oncol. 2011 Mar;7(3):339-54. doi: 10.2217/fon.11.8. PubMed PMID: 21417900.

55: Grau S, Thorsteinsdottir J, von Baumgarten L, Winkler F, Tonn JC, Schichor C. Bevacizumab can induce reactivity to VEGF-C and -D in human brain and tumour derived endothelial cells. J Neurooncol. 2011 Aug;104(1):103-12. doi: 10.1007/s11060-010-0480-6. Epub 2011 Feb 11. PubMed PMID: 21308397.

56: Kunz M, Thon N, Eigenbrod S, Hartmann C, Egensperger R, Herms J, Geisler J, la Fougere C, Lutz J, Linn J, Kreth S, von Deimling A, Tonn JC, Kretzschmar HA, Pöpperl G, Kreth FW. Hot spots in dynamic (18)FET-PET delineate malignant tumor parts within suspected WHO grade II gliomas. Neuro Oncol. 2011 Mar;13(3):307-16. doi: 10.1093/neuonc/noq196. Epub 2011 Feb 3. PubMed PMID: 21292686; PubMed Central PMCID: PMC3064604.

57: Stavrinou P, Kunz M, Lehner M, Heger A, Müller-Felber W, Tonn JC, Peraud A. Children with tethered cord syndrome of different etiology benefit from microsurgery-a single institution experience. Childs Nerv Syst. 2011 May;27(5):803-10. doi: 10.1007/s00381-010-1374-9. Epub 2011 Jan 6. PubMed PMID: 21210127.

58: Niyazi M, Siefert A, Schwarz SB, Ganswindt U, Kreth FW, Tonn JC, Belka C. Therapeutic options for recurrent malignant glioma. Radiother Oncol. 2011 Jan;98(1):1-14. doi: 10.1016/j.radonc.2010.11.006. Epub 2010 Dec 13. Review. PubMed PMID: 21159396.

59: Tonn JC, Schichor C, Schnell O, Zausinger S, Uhl E, Morhard D, Reiser M. Intraoperative computed tomography. Acta Neurochir Suppl. 2011;109:163-7. doi: 10.1007/978-3-211-99651-5_25. PubMed PMID: 20960337.

60: Thon N, Eigenbrod S, Grasbon-Frodl EM, Lutz J, Kreth S, Popperl G, Belka C, Kretzschmar HA, Tonn JC, Kreth FW. Predominant influence of MGMT methylation in non-resectable glioblastoma after radiotherapy plus temozolomide. J Neurol Neurosurg Psychiatry. 2011 Apr;82(4):441-6. doi: 10.1136/jnnp.2010.214593. Epub 2010 Sep 22. PubMed PMID: 20861061.

61: Ruge MI, Ilmberger J, Tonn JC, Kreth FW. Health-related quality of life and cognitive functioning in adult patients with supratentorial WHO grade II glioma: status prior to therapy. J Neurooncol. 2011 May;103(1):129-36. doi: 10.1007/s11060-010-0364-9. Epub 2010 Sep 5. PubMed PMID: 20820874.

62: Kopp C, Fauser C, Müller A, Astner ST, Jacob V, Lumenta C, Meyer B, Tonn JC, Molls M, Grosu AL. Stereotactic fractionated radiotherapy and LINAC radiosurgery in the treatment of vestibular schwannoma-report about both stereotactic methods from a single institution. Int J Radiat Oncol Biol Phys. 2011 Aug 1;80(5):1485-91. doi: 10.1016/j.ijrobp.2010.04.057. Epub 2010 Aug 12. PubMed PMID: 20708852.

63: Stupp R, Hegi ME, Neyns B, Goldbrunner R, Schlegel U, Clement PM, Grabenbauer GG, Ochsenbein AF, Simon M, Dietrich PY, Pietsch T, Hicking C, Tonn JC, Diserens AC, Pica A, Hermisson M, Krueger S, Picard M, Weller M. Phase I/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma. J Clin Oncol. 2010 Jun 1;28(16):2712-8. doi: 10.1200/JCO.2009.26.6650. Epub 2010 May 3. PubMed PMID: 20439646.

64: Stummer W, Tonn JC, Mehdorn HM, Nestler U, Franz K, Goetz C, Bink A, Pichlmeier U; ALA-Glioma Study Group. Counterbalancing risks and gains from extended resections in malignant glioma surgery: a supplemental analysis from the randomized 5-aminolevulinic acid glioma resection study. Clinical article. J Neurosurg. 2011 Mar;114(3):613-23. doi: 10.3171/2010.3.JNS097. Epub 2010 Apr 16. PubMed PMID: 20397896.

65: Rachinger W, Grau S, Tonn JC. Different microsurgical approaches to meningiomas of the anterior cranial base. Acta Neurochir (Wien). 2010 Jun;152(6):931-9. doi: 10.1007/s00701-010-0646-1. Epub 2010 Apr 11. Review. PubMed PMID: 20383724.

66: Weiss C, Witt TN, Fesl G, Geisler J, Tonn JC. [Angiographic moyamoya in a female with glycogenosis type IA - a case report focusing therapeutic management: bilateral encephalo-duro-arterio-myo-synangiosis (EDAMS)]. Fortschr Neurol Psychiatr. 2010 Mar;78(3):154-60. doi: 10.1055/s-0029-1245175. Epub 2010 Mar 8. German. PubMed PMID: 20213581.

67: Giese A, Winkler PA, Schichor C, Kantelhardt SR, Boeckh-Behrens T, Tonn JC, Rohde V. A transmedullary approach to occlusion of a ventral perimedullary arteriovenous fistula of the thoracic spinal cord. Neurosurgery. 2010 Mar;66(3):611-5; discussion 615. doi: 10.1227/01.NEU.0000365365.10977.48. PubMed PMID: 20173556.

68: Eroes CA, Zausinger S, Kreth FW, Goldbrunner R, Tonn JC. Intramedullary low grade astrocytoma and ependymoma. Surgical results and predicting factors for clinical outcome. Acta Neurochir (Wien). 2010 Apr;152(4):611-8. doi: 10.1007/s00701-009-0577-x. Epub 2010 Feb 1. PubMed PMID: 20119838.

69: Kreth FW, Thon N, Siefert A, Tonn JC. The place of interstitial brachytherapy and radiosurgery for low-grade gliomas. Adv Tech Stand Neurosurg. 2010;35:183-212. Review. PubMed PMID: 20102115.

70: Zausinger S, Scheder B, Uhl E, Heigl T, Morhard D, Tonn JC. Intraoperative computed tomography with integrated navigation system in spinal stabilizations. Spine (Phila Pa 1976). 2009 Dec 15;34(26):2919-26. doi: 10.1097/BRS.0b013e3181b77b19. PubMed PMID: 20010400.

71: Schichor C, Rachinger W, Morhard D, Zausinger S, Heigl TJ, Reiser M, Tonn JC. Intraoperative computed tomography angiography with computed tomography perfusion imaging in vascular neurosurgery: feasibility of a new concept. J Neurosurg. 2010 Apr;112(4):722-8. doi: 10.3171/2009.9.JNS081255. PubMed PMID: 19817544.

72: Thon N, Eigenbrod S, Grasbon-Frodl EM, Ruiter M, Mehrkens JH, Kreth S, Tonn JC, Kretzschmar HA, Kreth FW. Novel molecular stereotactic biopsy procedures reveal intratumoral homogeneity of loss of heterozygosity of 1p/19q and TP53 mutations in World Health Organization grade II gliomas. J Neuropathol Exp Neurol. 2009 Nov;68(11):1219-28. doi: 10.1097/NEN.0b013e3181bee1f1. PubMed PMID: 19816195.

73: Muacevic A, Kufeld M, Wowra B, Kreth FW, Tonn JC. Feasibility, safety, and outcome of frameless image-guided robotic radiosurgery for brain metastases. J Neurooncol. 2010 Apr;97(2):267-74. doi: 10.1007/s11060-009-0023-1. Epub 2009 Oct 4. PubMed PMID: 19802718.

74: Wowra B, Muacevic A, Zausinger S, Tonn JC. Radiosurgery for spinal malignant tumors. Dtsch Arztebl Int. 2009 Feb;106(7):106-12. doi: 10.3238/arztebl.2009.0106. Epub 2009 Feb 13. Review. PubMed PMID: 19562022; PubMed Central PMCID: PMC2696242.

75: Rachinger W, Grau S, Holtmannspötter M, Herms J, Tonn JC, Kreth FW. Serial stereotactic biopsy of brainstem lesions in adults improves diagnostic accuracy compared with MRI only. J Neurol Neurosurg Psychiatry. 2009 Oct;80(10):1134-9. doi: 10.1136/jnnp.2009.174250. Epub 2009 Jun 10. PubMed PMID: 19520698.

76: Uhl E, Zausinger S, Morhard D, Heigl T, Scheder B, Rachinger W, Schichor C, Tonn JC. Intraoperative computed tomography with integrated navigation system in a multidisciplinary operating suite. Neurosurgery. 2009 May;64(5 Suppl 2):231-9; discussion 239-40. doi: 10.1227/01.NEU.0000340785.51492.B5. PubMed PMID: 19404103.

77: Schnell O, Krebs B, Carlsen J, Miederer I, Goetz C, Goldbrunner RH, Wester HJ, Haubner R, Pöpperl G, Holtmannspötter M, Kretzschmar HA, Kessler H, Tonn JC, Schwaiger M, Beer AJ. Imaging of integrin alpha(v)beta(3) expression in patients with malignant glioma by [18F] Galacto-RGD positron emission tomography. Neuro Oncol. 2009 Dec;11(6):861-70. doi: 10.1215/15228517-2009-024. Epub . PubMed PMID: 19401596; PubMed Central PMCID: PMC2802406.

78: Schöller K, Licht S, Tonn JC, Uhl E. Randomized controlled trials in neurosurgery–how good are we? Acta Neurochir (Wien). 2009 May;151(5):519-27; discussion 527. doi: 10.1007/s00701-009-0280-y. Epub 2009 Apr 1. Review. PubMed PMID: 19337684.

79: Ardeshiri A, Radina C, Edlauer M, Ardeshiri A, Riepertinger A, Nerlich A, Tonn JC, Winkler PA. Evaluation of new radiolucent polymer headholder pins for use in intraoperative computed tomography. J Neurosurg. 2009 Dec;111(6):1168-74. doi: 10.3171/2009.1.JNS08862. PubMed PMID: 19301958.

80: Wowra B, Muacevic A, Tonn JC, Schoenberg SO, Reiser M, Herrmann KA. Obliteration dynamics in cerebral arteriovenous malformations after cyberknife radiosurgery: quantification with sequential nidus volumetry and 3-tesla 3-dimensional time-of-flight magnetic resonance angiography. Neurosurgery. 2009 Feb;64(2 Suppl):A102-9. doi: 10.1227/01.NEU.0000339201.31176.C9. PubMed PMID: 19165066.

81: Wowra B, Zausinger S, Drexler C, Kufeld M, Muacevic A, Staehler M, Tonn JC. CyberKnife radiosurgery for malignant spinal tumors: characterization of well-suited patients. Spine (Phila Pa 1976). 2008 Dec 15;33(26):2929-34. doi: 10.1097/BRS.0b013e31818c680a. PubMed PMID: 19092627.

82: Ilmberger J, Ruge M, Kreth FW, Briegel J, Reulen HJ, Tonn JC. Intraoperative mapping of language functions: a longitudinal neurolinguistic analysis. J Neurosurg. 2008 Oct;109(4):583-92. doi: 10.3171/JNS/2008/109/10/0583. PubMed PMID: 18826344.

83: Schichor C, Witte J, Schöller K, Tanner P, Uhl E, Goldbrunner R, Tonn JC. Magnetically guided neuronavigation of flexible instruments in shunt placement, transsphenoidal procedures, and craniotomies. Neurosurgery. 2008 Jul;63(1 Suppl 1):ONS121-7; discussion ONS127-8. doi: 10.1227/01.neu.0000335026.00650.ca. PubMed PMID: 18728589.

84: Thon N, Damianoff K, Hegermann J, Grau S, Krebs B, Schnell O, Tonn JC, Goldbrunner R. Presence of pluripotent CD133+ cells correlates with malignancy of gliomas. Mol Cell Neurosci. 2010 Jan;43(1):51-9. doi: 10.1016/j.mcn.2008.07.022. Epub 2008 Aug 7. PubMed PMID: 18761091.

85: Schnell O, Schöller K, Ruge M, Siefert A, Tonn JC, Kreth FW. Surgical resection plus stereotactic 125I brachytherapy in adult patients with eloquently located supratentorial WHO grade II glioma - feasibility and outcome of a combined local treatment concept. J Neurol. 2008 Oct;255(10):1495-502. doi: 10.1007/s00415-008-0948-x. Epub 2008 Jul 25. PubMed PMID: 18677635.

86: Wowra B, Muacevic A, Tonn JC. [Leksell gamma knife]. MMW Fortschr Med. 2004 Jan 15;146(1-2):56-7. Review. German. PubMed PMID: 18437870.

87: Stummer W, Reulen HJ, Meinel T, Pichlmeier U, Schumacher W, Tonn JC, Rohde V, Oppel F, Turowski B, Woiciechowsky C, Franz K, Pietsch T; ALA-Glioma Study Group. Extent of resection and survival in glioblastoma multiforme: identification of and adjustment for bias. Neurosurgery. 2008 Mar;62(3):564-76; discussion 564-76. doi: 10.1227/01.neu.0000317304.31579.17. PubMed PMID: 18425006.

88: Schnell O, Krebs B, Wagner E, Romagna A, Beer AJ, Grau SJ, Thon N, Goetz C, Kretzschmar HA, Tonn JC, Goldbrunner RH. Expression of integrin alphavbeta3 in gliomas correlates with tumor grade and is not restricted to tumor vasculature. Brain Pathol. 2008 Jul;18(3):378-86. doi: 10.1111/j.1750-3639.2008.00137.x. Epub 2008 Apr 2. PubMed PMID: 18394009; PubMed Central PMCID: PMC2607528.

89: Mehrkens JH, Pöpperl G, Rachinger W, Herms J, Seelos K, Tatsch K, Tonn JC, Kreth FW. The positive predictive value of O-(2-[18F]fluoroethyl)-L-tyrosine (FET) PET in the diagnosis of a glioma recurrence after multimodal treatment. J Neurooncol. 2008 May;88(1):27-35. doi: 10.1007/s11060-008-9526-4. Epub 2008 Jan 23. PubMed PMID: 18217207.

90: Uhl E, Holtmannspötter M, Tonn JC. Improvement of Brown-Sequard syndrome after surgical repair of an idiopathic thoracic spinal cord herniation. J Neurol. 2008 Jan;255(1):125-6. doi: 10.1007/s00415-008-0553-z. Epub 2008 Jan 22. PubMed PMID: 18204810.

91: Eroes CA, Barth C, Tonn JC, Reulen HJ. The revised European neurosurgical electronic logbook of operations. Acta Neurochir (Wien). 2008 Feb;150(2):195-8. doi: 10.1007/s00701-007-1469-6. Epub 2008 Jan 2. Review. PubMed PMID: 18166991.

92: Tonn JC, Stummer W. Fluorescence-guided resection of malignant gliomas using 5-aminolevulinic acid: practical use, risks, and pitfalls. Clin Neurosurg. 2008;55:20-6. Review. PubMed PMID: 19248665.

93: Muacevic A, Wowra B, Siefert A, Tonn JC, Steiger HJ, Kreth FW. Microsurgery plus whole brain irradiation versus Gamma knife radiosurgery alone for treatment of single metastases to the brain: a randomized controlled multicentre phase III trial. J Neurooncol. 2008 May;87(3):299-307. Epub 2007 Dec 22. PubMed PMID: 18157648.

94: Tonn JC. Awake craniotomy for monitoring of language function: benefits and limits. Acta Neurochir (Wien). 2007 Dec;149(12):1197-8. PubMed PMID: 18075724.

95: Stummer W, Beck T, Beyer W, Mehrkens JH, Obermeier A, Etminan N, Stepp H, Tonn JC, Baumgartner R, Herms J, Kreth FW. Long-sustaining response in a patient with non-resectable, distant recurrence of glioblastoma multiforme treated by interstitial photodynamic therapy using 5-ALA: case report. J Neurooncol. 2008 Mar;87(1):103-9. Epub 2007 Nov 23. PubMed PMID: 18034212.

96: Tanner PG, Holtmannspötter M, Tonn JC, Goldbrunner R. Effects of drug efflux on convection-enhanced paclitaxel delivery to malignant gliomas: technical note. Neurosurgery. 2007 Oct;61(4):E880-2; discussion E882. PubMed PMID: 17986926.

97: Winkler PA, Zausinger S, Milz S, Buettner A, Wiesmann M, Tonn JC. Morphometric studies of the ligamentum flavum: a correlative microanatomical and MRI study of the lumbar spine. Zentralbl Neurochir. 2007 Nov;68(4):200-4. Epub 2007 Oct 26. PubMed PMID: 17963193.

98: Stepp H, Beck T, Pongratz T, Meinel T, Kreth FW, Tonn JCh, Stummer W. ALA and malignant glioma: fluorescence-guided resection and photodynamic treatment. J Environ Pathol Toxicol Oncol. 2007;26(2):157-64. PubMed PMID: 17725542.

99: Grasbon-Frodl EM, Kreth FW, Ruiter M, Schnell O, Bise K, Felsberg J, Reifenberger G, Tonn JC, Kretzschmar HA. Intratumoral homogeneity of MGMT promoter hypermethylation as demonstrated in serial stereotactic specimens from anaplastic astrocytomas and glioblastomas. Int J Cancer. 2007 Dec 1;121(11):2458-64. PubMed PMID: 17691113.

100: Zausinger S, Mehrkens JH, März U, Rothwinkler M, Uhl E, Tonn JC. [Surgical treatment of lumbar spinal canal stenosis in elderly patients]. MMW Fortschr Med. 2006 Oct 26;148(43):29-32. German. PubMed PMID: 17619420.

101: Uhl E, Zausinger S, März U, Rothwinkler M, Tonn JC. [Surgical treatment of cervical spinal canal stenosis in elderly patients]. MMW Fortschr Med. 2006 Oct 26;148(43):26-8. German. PubMed PMID: 17619419.

102: Ardeshiri A, Ardeshiri A, Linn J, Tonn JC, Winkler PA. Microsurgical anatomy of the mesencephalic veins. J Neurosurg. 2007 May;106(5):894-9. PubMed PMID: 17542536.

103: Ardeshiri A, Ardeshiri A, Tonn JC, Witt TN. [Clinical and diagnostic characteristics of T1 root syndrome]. Nervenarzt. 2007 Aug;78(8):931-6. German. PubMed PMID: 17457557.

104: Grau SJ, Trillsch F, Herms J, Thon N, Nelson PJ, Tonn JC, Goldbrunner R. Expression of VEGFR3 in glioma endothelium correlates with tumor grade. J Neurooncol. 2007 Apr;82(2):141-50. Epub 2006 Nov 17. PubMed PMID: 17115285.

105: Muacevic A, Staehler M, Drexler C, Wowra B, Reiser M, Tonn JC. Technical description, phantom accuracy, and clinical feasibility for fiducial-free frameless real-time image-guided spinal radiosurgery. J Neurosurg Spine. 2006 Oct;5(4):303-12. PubMed PMID: 17048766.

106: Peraud A, Goetz C, Siefert A, Tonn JC, Kreth FW. Interstitial iodine-125 radiosurgery alone or in combination with microsurgery for pediatric patients with eloquently located low-grade glioma: a pilot study. Childs Nerv Syst. 2007 Jan;23(1):39-46. Epub 2006 Sep 14. PubMed PMID: 16972111.

107: Schichor C, Birnbaum T, Etminan N, Schnell O, Grau S, Miebach S, Aboody K, Padovan C, Straube A, Tonn JC, Goldbrunner R. Vascular endothelial growth factor A contributes to glioma-induced migration of human marrow stromal cells (hMSC). Exp Neurol. 2006 Jun;199(2):301-10. Epub 2006 Mar 29. PubMed PMID: 16574102.

108: Ardeshiri A, Ardeshiri A, Tonn JC, Winkler PA. Microsurgical anatomy of the lateral mesencephalic vein and its meaning for the deep venous outflow of the brain. Neurosurg Rev. 2006 Apr;29(2):154-8; discussion 158. Epub 2006 Mar 14. PubMed PMID: 16534634.

109: Zausinger S, Yousry I, Brueckmann H, Schmid-Elsaesser R, Tonn JC. Cavernous malformations of the brainstem: three-dimensional-constructive interference in steady-state magnetic resonance imaging for improvement of surgical approach and clinical results. Neurosurgery. 2006 Feb;58(2):322-30; discussion 322-30. PubMed PMID: 16462486.

110: Staender M, Maerz U, Tonn JC, Steude U. Computerized tomography-guided kryorhizotomy in 76 patients with lumbar facet joint syndrome. J Neurosurg Spine. 2005 Dec;3(6):444-9. PubMed PMID: 16381206.

111: Havel P, Braun B, Rau S, Tonn JC, Fesl G, Brückmann H, Ilmberger J. Reproducibility of activation in four motor paradigms. An fMRI study. J Neurol. 2006 Apr;253(4):471-6. Epub 2005 Nov 14. PubMed PMID: 16283098.

112: Miebach S, Grau S, Hummel V, Rieckmann P, Tonn JC, Goldbrunner RH. Isolation and culture of microvascular endothelial cells from gliomas of different WHO grades. J Neurooncol. 2006 Jan;76(1):39-48. PubMed PMID: 16155723.

113: Rachinger W, Goetz C, Pöpperl G, Gildehaus FJ, Kreth FW, Holtmannspötter M, Herms J, Koch W, Tatsch K, Tonn JC. Positron emission tomography with O-(2-[18F]fluoroethyl)-l-tyrosine versus magnetic resonance imaging in the diagnosis of recurrent gliomas. Neurosurgery. 2005 Sep;57(3):505-11; discussion 505-11. PubMed PMID: 16145529.

114: Schichor C, Kerkau S, Visted T, Martini R, Bjerkvig R, Tonn JC, Goldbrunner R. The brain slice chamber, a novel variation of the Boyden Chamber Assay, allows time-dependent quantification of glioma invasion into mammalian brain in vitro. J Neurooncol. 2005 May;73(1):9-18. PubMed PMID: 15933811.

115: Wowra B, Muacevic A, Jess-Hempen A, Tonn JC. Safety and efficacy of outpatient gamma knife radiosurgery for multiple cerebral metastases. Expert Rev Neurother. 2004 Jul;4(4):673-9. Review. PubMed PMID: 15853586.

116: Muacevic A, Siebels M, Tonn JC, Wowra B. Treatment of brain metastases in renal cell carcinoma: radiotherapy, radiosurgery, or surgery? World J Urol. 2005 Jul;23(3):180-4. Epub 2005 Mar 25. Review. PubMed PMID: 15791468.

117: Tonn JC. Microneurosurgery and radiosurgery–an attractive combination. Acta Neurochir Suppl. 2004;91:103-8. PubMed PMID: 15707031.

118: Wowra B, Muacevic A, Müller-Schunk S, Tonn JC. Special indications in gamma knife surgery. Acta Neurochir Suppl. 2004;91:89-102. PubMed PMID: 15707030.

119: Muacevic A, Jess-Hempen A, Tonn JC, Wowra B. Results of outpatient gamma knife radiosurgery for primary therapy of acoustic neuromas. Acta Neurochir Suppl. 2004;91:75-8. PubMed PMID: 15707028.

120: Muacevic A, Jess-Hempen A, Tonn JC, Wowra B. Clinical quality standards for gamma knife radiosurgery–the Munich protocol. Acta Neurochir Suppl. 2004;91:25-32. PubMed PMID: 15707023.

121: Wowra B, Muacevic A, Jess-Hempen A, Hempel JM, Müller-Schunk S, Tonn JC. Outpatient Gamma knife radiosurgery for vestibular schwannoma: definition of the therapeutic profile based on a 10-year experience. J Neurosurg. 2005 Jan;102 Suppl:114-8. PubMed PMID: 15662792.

122: Muacevic A, Peller M, Ruprecht L, Berg D, Fend L, Sroka R, Reulen HJ, Reiser M, Tonn JCh, Kreth FW. Image guided interstitial laser thermotherapy: a canine model evaluated by magnetic resonance imaging and quantitative autoradiography. Acta Neurochir (Wien). 2005 Feb;147(2):175-85; discussion 185-6. PubMed PMID: 15565485.

123: Winkler PA, Tonn JC. Problem-based learning in residency training and the tutorial process for training and education in neurosurgery. Acta Neurochir Suppl. 2004;90:73-6. PubMed PMID: 15553120.

124: Tonn JC. [Treatment concepts for glioma are always case-to-case decisions. Individuality determines success]. MMW Fortschr Med. 2004 Apr 1;146(14):23. German. PubMed PMID: 15452922.

125: Goetz CM, Rachinger W, Decker M, Gildehaus FJ, Stocker S, Jung G, Tatsch K, Tonn JC, Reulen HJ. Distribution of labelled anti-tenascin antibodies and fragments after injection into intact or partly resected C6-gliomas in rats. Cancer Immunol Immunother. 2005 Apr;54(4):337-44. Epub 2004 Sep 24. PubMed PMID: 15449040.

126: Muacevic A, Kreth FW, Mack A, Tonn JC, Wowra B. Stereotactic radiosurgery without radiation therapy providing high local tumor control of multiple brain metastases from renal cell carcinoma. Minim Invasive Neurosurg. 2004 Aug;47(4):203-8. PubMed PMID: 15346315.

127: Kreth FW, Peraud A, Tonn JC. [Individualized treatment strategies in adults with supratentorial WHO grade II gliomas]. MMW Fortschr Med. 2004 Apr 1;146(14):26-8. Review. German. PubMed PMID: 15344747.

128: Goetz C, Peraud A, Kreth FW, Tonn JC. [Pilocytic astrocytoma in childhood]. MMW Fortschr Med. 2004 Apr 1;146(14):24-5. Review. German. PubMed PMID: 15344746.

129: Goldbrunner RH, Bendszus M, Wood J, Kiderlen M, Sasaki M, Tonn JC. PTK787/ZK222584, an inhibitor of vascular endothelial growth factor receptor tyrosine kinases, decreases glioma growth and vascularization. Neurosurgery. 2004 Aug;55(2):426-32; discussion 432. PubMed PMID: 15271251.

130: Muacevic A, Kreth FW, Tonn JC, Wowra B. Stereotactic radiosurgery for multiple brain metastases from breast carcinoma. Cancer. 2004 Apr 15;100(8):1705-11. PubMed PMID: 15073860.

131: Giese A, Kucinski T, Knopp U, Goldbrunner R, Hamel W, Mehdorn HM, Tonn JC, Hilt D, Westphal M. Pattern of recurrence following local chemotherapy with biodegradable carmustine (BCNU) implants in patients with glioblastoma. J Neurooncol. 2004 Feb;66(3):351-60. PubMed PMID: 15015668.

132: Goldbrunner RH, Bendszus M, Tonn JC. Protocol for MRI monitoring of orthotopic glioma growth in the rat brain. Cancer Treat Res. 2004;117:139-40. PubMed PMID: 15015557.

133: Goldbrunner RH, Bendszus M, Tonn JC. Protocol for isolation of HCEC. Cancer Treat Res. 2004;117:137-8. PubMed PMID: 15015556.

134: Goldbrunner RH, Bendszus M, Tonn JC. Models for angiogenesis in gliomas. Cancer Treat Res. 2004;117:115-35. Review. PubMed PMID: 15015555.

135: Peraud A, Herms J, Schlegel J, Müller P, Kretzschmar H, Tonn JC. Recurrent spinal cord astrocytoma with intraventricular seeding. Childs Nerv Syst. 2004 Feb;20(2):114-8. Epub 2003 Sep 30. PubMed PMID: 14762681.

136: Goetz C, Rachinger W, Poepperl G, Decker M, Gildehaus FJ, Stocker S, Jung G, Tatsch K, Tonn JC, Reulen HJ. Intralesional radioimmunotherapy in the treatment of malignant glioma: clinical and experimental findings. Acta Neurochir Suppl. 2003;88:69-75. PubMed PMID: 14531564.

137: Stummer W, Reulen HJ, Novotny A, Stepp H, Tonn JC. Fluorescence-guided resections of malignant gliomas–an overview. Acta Neurochir Suppl. 2003;88:9-12. PubMed PMID: 14531555.

138: Wagner S, Fueller T, Hummel V, Rieckmann P, Tonn JC. Influence of VEGF-R2 inhibition on MMP secretion and motility of microvascular human cerebral endothelial cells (HCEC). J Neurooncol. 2003 May;62(3):221-31. PubMed PMID: 12777073.

139: Tonn JC. Model systems in neurooncology. Acta Neurochir Suppl. 2002;83:79-83. PubMed PMID: 12442625.

140: Vajkoczy P, Farhadi M, Gaumann A, Heidenreich R, Erber R, Wunder A, Tonn JC, Menger MD, Breier G. Microtumor growth initiates angiogenic sprouting with simultaneous expression of VEGF, VEGF receptor-2, and angiopoietin-2. J Clin Invest. 2002 Mar;109(6):777-85. PubMed PMID: 11901186; PubMed Central PMCID: PMC150910.

141: Vince GH, Herbold C, Klein R, Kühl J, Pietsch T, Franz S, Roosen K, Tonn JC. Medulloblastoma displays distinct regional matrix metalloprotease expression. J Neurooncol. 2001 Jun;53(2):99-106. PubMed PMID: 11716074.

142: Schweitzer T, Vince GH, Herbold C, Roosen K, Tonn JC. Extraneural metastases of primary brain tumors. J Neurooncol. 2001 Jun;53(2):107-14. Review. PubMed PMID: 11716064.

143: Goldbrunner RH, Wagner S, Roosen K, Tonn JC. Models for assessment of angiogenesis in gliomas. J Neurooncol. 2000 Oct-Nov;50(1-2):53-62. Review. PubMed PMID: 11245281.

144: Goldbrunner RH, Bendszus M, Sasaki M, Kraemer T, Plate KH, Roosen K, Tonn JC. Vascular endothelial growth factor-driven glioma growth and vascularization in an orthotopic rat model monitored by magnetic resonance imaging. Neurosurgery. 2000 Oct;47(4):921-9; discussion 929-30. PubMed PMID: 11014432.

145: Bouterfa HL, Sattelmeyer V, Czub S, Vordermark D, Roosen K, Tonn JC. Inhibition of Ras farnesylation by lovastatin leads to downregulation of proliferation and migration in primary cultured human glioblastoma cells. Anticancer Res. 2000 Jul-Aug;20(4):2761-71. PubMed PMID: 10953355.

146: Tonn JC, Schlake HP, Goldbrunner R, Milewski C, Helms J, Roosen K. Acoustic neuroma surgery as an interdisciplinary approach: a neurosurgical series of 508 patients. J Neurol Neurosurg Psychiatry. 2000 Aug;69(2):161-6. PubMed PMID: 10896686; PubMed Central PMCID: PMC1737058.

147: Vajkoczy P, Menger MD, Goldbrunner R, Ge S, Fong TA, Vollmar B, Schilling L, Ullrich A, Hirth KP, Tonn JC, Schmiedek P, Rempel SA. Targeting angiogenesis inhibits tumor infiltration and expression of the pro-invasive protein SPARC. Int J Cancer. 2000 Jul 15;87(2):261-8. PubMed PMID: 10861485.

148: Goldbrunner RH, Schlake HP, Milewski C, Tonn JC, Helms J, Roosen K. Quantitative parameters of intraoperative electromyography predict facial nerve outcomes for vestibular schwannoma surgery. Neurosurgery. 2000 May;46(5):1140-6; discussion 1146-8. PubMed PMID: 10807246.

149: Goldbrunner RH, Bernstein JJ, Plate KH, Vince GH, Roosen K, Tonn JC. Vascularization of human glioma spheroids implanted into rat cortex is conferred by two distinct mechanisms. J Neurosci Res. 1999 Feb 15;55(4):486-95. PubMed PMID: 10723058.

150: Bendszus M, Warmuth-Metz M, Klein R, Burger R, Schichor C, Tonn JC, Solymosi L. MR spectroscopy in gliomatosis cerebri. AJNR Am J Neuroradiol. 2000 Feb;21(2):375-80. PubMed PMID: 10696026.

151: Bouterfa H, Picht T, Kess D, Herbold C, Noll E, Black PM, Roosen K, Tonn JC. Retinoids inhibit human glioma cell proliferation and migration in primary cell cultures but not in established cell lines. Neurosurgery. 2000 Feb;46(2):419-30. PubMed PMID: 10690732.

152: Bouterfa H, Darlapp AR, Klein E, Pietsch T, Roosen K, Tonn JC. Expression of different extracellular matrix components in human brain tumor and melanoma cells in respect to variant culture conditions. J Neurooncol. 1999 Aug;44(1):23-33. PubMed PMID: 10582665.

153: Kaczarek E, Zapf S, Bouterfa H, Tonn JC, Westphal M, Giese A. Dissecting glioma invasion: interrelation of adhesion, migration and intercellular contacts determine the invasive phenotype. Int J Dev Neurosci. 1999 Aug-Oct;17(5-6):625-41. PubMed PMID: 10571423.

154: Goldbrunner RH, Pietsch T, Vince GH, Bernstein JJ, Wagner S, Hageman H, Selby DM, Krauss J, Soerensen N, Tonn JC. Different vascular patterns of medulloblastoma and supratentorial primitive neuroectodermal tumors. Int J Dev Neurosci. 1999 Aug-Oct;17(5-6):593-9. PubMed PMID: 10571420.

155: Vajkoczy P, Goldbrunner R, Farhadi M, Vince G, Schilling L, Tonn JC, Schmiedek P, Menger MD. Glioma cell migration is associated with glioma-induced angiogenesis in vivo. Int J Dev Neurosci. 1999 Aug-Oct;17(5-6):557-63. PubMed PMID: 10571417.

156: Chintala SK, Tonn JC, Rao JS. Matrix metalloproteinases and their biological function in human gliomas. Int J Dev Neurosci. 1999 Aug-Oct;17(5-6):495-502. Review. PubMed PMID: 10571411.

157: Vince GH, Wagner S, Pietsch T, Klein R, Goldbrunner RH, Roosen K, Tonn JC. Heterogeneous regional expression patterns of matrix metalloproteinases in human malignant gliomas. Int J Dev Neurosci. 1999 Aug-Oct;17(5-6):437-45. PubMed PMID: 10571406.

158: Tonn J, Hoffmann O, Hofmann E, Schlake HP, Sörensen N, Roosen K. “De novo” formation of intracranial aneurysms: who is at risk? Neuroradiology. 1999 Sep;41(9):674-9. PubMed PMID: 10525770.

159: Wagner S, Czub S, Greif M, Vince GH, Süss N, Kerkau S, Rieckmann P, Roggendorf W, Roosen K, Tonn JC. Microglial/macrophage expression of interleukin 10 in human glioblastomas. Int J Cancer. 1999 Jul 2;82(1):12-6. PubMed PMID: 10360813.

160: Goldbrunner RH, Bernstein JJ, Tonn JC. Cell-extracellular matrix interaction in glioma invasion. Acta Neurochir (Wien). 1999;141(3):295-305; discussion 304-5. Review. PubMed PMID: 10214487.

161: Tonn JC, Kerkau S, Hanke A, Bouterfa H, Mueller JG, Wagner S, Vince GH, Roosen K. Effect of synthetic matrix-metalloproteinase inhibitors on invasive capacity and proliferation of human malignant gliomas in vitro. Int J Cancer. 1999 Mar 1;80(5):764-72. PubMed PMID: 10048980.

162: Wagner S, Stegen C, Bouterfa H, Huettner C, Kerkau S, Roggendorf W, Roosen K, Tonn JC. Expression of matrix metalloproteinases in human glioma cell lines in the presence of IL-10. J Neurooncol. 1998 Nov;40(2):113-22. PubMed PMID: 9892093.

163: Goldbrunner RH, Bernstein JJ, Tonn JC. ECM-mediated glioma cell invasion. Microsc Res Tech. 1998 Nov 1;43(3):250-7. Review. PubMed PMID: 9840803.

164: Tonn JC, Wunderlich S, Kerkau S, Klein CE, Roosen K. Invasive behaviour of human gliomas is mediated by interindividually different integrin patterns. Anticancer Res. 1998 Jul-Aug;18(4A):2599-605. PubMed PMID: 9703915.

165: Berweiler U, Krone A, Tonn JC. Reservoir systems for intraventricular chemotherapy. J Neurooncol. 1998 Jun-Jul;38(2-3):141-3. Review. PubMed PMID: 9696364.

166: Goldbrunner RH, Bouterfa H, Vince GH, Bernstein JJ, Roosen K, Tonn JC. Transfection and dye premarking of human and rat glioma cell lines affects adhesion, migration and proliferation. Anticancer Res. 1997 Nov-Dec;17(6D):4467-71. PubMed PMID: 9494552.

167: Bouterfa H, Janka M, Meese E, Kerkau S, Roosen K, Tonn JC. Effect of changes in the CD44 gene on tumour cell invasion in gliomas. Neuropathol Appl Neurobiol. 1997 Oct;23(5):373-9. PubMed PMID: 9364462.

168: Tonn JC, Ott MM, Bouterfa H, Kerkau S, Kapp M, Müller-Hermelink HK, Roosen K. Inverse correlation of cell proliferation and expression of progesterone receptors in tumor spheroids and monolayer cultures of human meningiomas. Neurosurgery. 1997 Nov;41(5):1152-9. PubMed PMID: 9361071.

169: Vince GH, Bouterfa H, Goldbrunner R, Roosen K, Tonn JC. Fast blue, a fluorescent tracer in glioma cell culture, affects cell proliferation and motility. Neurosci Lett. 1997 Sep 19;233(2-3):148-50. PubMed PMID: 9350854.

170: Tonn JC, Paulus W, Warmuth-Metz M, Schachenmayr W, Sörensen N, Roosen K. Pleomorphic xanthoastrocytoma: report of six cases with special consideration of diagnostic and therapeutic pitfalls. Surg Neurol. 1997 Feb;47(2):162-9. Review. PubMed PMID: 9040821.

171: Goldbrunner RH, Haugland HK, Klein CE, Kerkau S, Roosen K, Tonn JC. ECM dependent and integrin mediated tumor cell migration of human glioma and melanoma cell lines under serum-free conditions. Anticancer Res. 1996 Nov-Dec;16(6B):3679-87. PubMed PMID: 9042241.

172: Janka M, Fischer U, Tonn JC, Kerkau S, Roosen K, Meese E. Comparative amplification analysis of human glioma tissue and glioma derived fragment spheroids using reverse chromosome painting (RCP). Anticancer Res. 1996 Sep-Oct;16(5A):2601-6. PubMed PMID: 8917357.

173: Goldbrunner R, Warmuth-Metz M, Tonn JC, Vince GH, Roosen K. Primary Ki-1-positive T-cell lymphoma of the brain–an aggressive subtype of lymphoma: case report and review of the literature. Surg Neurol. 1996 Jul;46(1):37-41. Review. PubMed PMID: 8677486.

174: Tonn JC, Ott MM, Paulus W, Meixensberger J, Roosen K. Progesterone receptors in tumor fragment spheroids of human meningiomas. Acta Neurochir Suppl. 1996;65:105-7. PubMed PMID: 8738509.

175: Tonn JC, Haugland HK, Saraste J, Roosen K, Laerum OD. Differential effects of vincristine and phenytoin on the proliferation, migration, and invasion of human glioma cell lines. J Neurosurg. 1995 Jun;82(6):1035-43. PubMed PMID: 7539063.

176: Tonn JC, Ott MM, Meixensberger J, Paulus W, Roosen K. Progesterone receptors are detectable in tumor fragment spheroids of meningiomas in vitro. Anticancer Res. 1994 Nov-Dec;14(6B):2453-6. PubMed PMID: 7872666.

177: Tonn JC, Schachenmayr W, Kraemer HP. In vitro chemosensitivity test of malignant gliomas: clinical relevance of test results independent of adjuvant chemotherapy. Anticancer Res. 1994 May-Jun;14(3B):1371-5. PubMed PMID: 8067708.

178: Tonn JC, Roosen K, Schachenmayr W. Brain necroses after intraarterial chemotherapy and irradiation of malignant gliomas–a complication of both ACNU and BCNU? J Neurooncol. 1991 Dec;11(3):241-2. PubMed PMID: 1823343.

179: Laun A, Tonn JC, Jerusalem C. Comparative study of lyophilized human dura mater and lyophilized bovine pericardium as dural substitutes in neurosurgery. Acta Neurochir (Wien). 1990;107(1-2):16-21. PubMed PMID: 2096603.

180: Laun A, Tonn JC. Cranial nerve lesions following subarachnoid hemorrhage and aneurysm of the circle of Willis. Neurosurg Rev. 1988;11(2):137-41. PubMed PMID: 3244411.

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