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A joint or articulation (or articulate surface) is the location at which bones connect.

They are constructed to allow movement (except for skull, sacral, sternal, and pelvic bones) and provide mechanical support, and are classified structurally and functionally.


Facet joint

Sacroiliac joint

Chronic joint pain is a widespread problem that frequently occurs with aging and trauma. Pain occurs most often in synovial joints, the body's load bearing joints. The mechanical and molecular mechanisms contributing to synovial joint pain are reviewed using two examples, the cervical spinal facet joints and temporomandibular joint. Although much work has focused on the macroscale mechanics of joints in health and disease, the combined influence of tissue mechanics, molecular processes, and nociception in joint pain has only recently become a focus. Trauma and repeated loading can induce structural and biochemical changes in joints, altering their microenvironment and modifying the biomechanics of their constitutive tissues, which themselves are innervated. Peripheral pain sensors, can become activated in response to changes in the joint microenvironment and relay pain signals to the spinal cord and brain where pain is processed and perceived. In some cases, pain circuitry is permanently changed, which may be a potential mechanism for sustained joint pain. However, it is most likely that alterations in both the joint microenvironment and CNS contribute to chronic pain. As such, the challenge of treating joint pain and degeneration is temporally and spatially complicated.

Sperry et al., in a review summarizes anatomy, physiology, and pathophysiology of these joints, and sensory pain relays. Pain pathways are postulated to be sensitized by many factors, including degeneration and biochemical priming, with effects on thresholds for mechanical injury and/or dysfunction. Initiators of joint pain are discussed in the context of clinical challenges including the diagnosis and treatment of pain 1).

Sperry MM, Ita ME, Kartha S, Zhang S, Yu YH, Winkelstein B. The Interface of Mechanics and Nociception in Joint Pathophysiology: Insights from the Facet & Temporomandibular Joints. J Biomech Eng. 2017 Jan 5. doi: 10.1115/1.4035647. [Epub ahead of print] PubMed PMID: 28056123.
joint.txt · Last modified: 2017/01/06 11:55 (external edit)