Ki-67 proliferation index

Proliferation-associated antigen Ki-67 is used for the histological evaluation of different tumors.

Antigen KI-67 also known as Ki-67 or MKI67 is a protein that in humans is encoded by the MKI67 gene (antigen identified by monoclonal antibody Ki-67).

Antigen KI-67 is a nuclear protein that is associated with and may be necessary for cellular proliferation. Furthermore it is associated with ribosomal RNA transcription.

Inactivation of antigen KI-67 leads to inhibition of ribosomal RNA synthesis.

see Ki67 for pituitary neuroendocrine tumor.

Fluorescein Sodium-guided resection of malignant glioma (MG) is safe and effective. In the boundary area of MG, fluorescence levels and Ki-67 proliferation index showed correlation. FLS-guided resection achieved the function of “reducing tumor cell,” thus reducing the proliferation index in the lesion area 1).

Zhang N, Shang Z, Wang Z, Meng X, Li Z, Tian H, Huang D, Yin X, Zheng B, Zhang X. Molecular pathological expression in malignant gliomas resected by fluorescein sodium-guiding under the YELLOW 560 nm surgical microscope filter. World J Surg Oncol. 2018 Oct 1;16(1):195. doi: 10.1186/s12957-018-1495-2. PubMed PMID: 30285781.
  • ki-67_proliferation_index.txt
  • Last modified: 2023/04/14 00:52
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