During the 1930s, white matter tracts began to assume relevance for neurosurgery, especially after Cajal's work. In many reviews of white matter neurobiology, the seminal contributions of Josef Klingler (1888-1963) and their neurological applications have been overlooked 1).

This freezing technique, first described by Josef Klingler and later revitalized by Uğur Türe et al. has already been reported to have a good correlation with diffusion tensor imaging (DTI) tractography 2).

Agrawal A, Kapfhammer JP, Kress A, Wichers H, Deep A, Feindel W, Sonntag VK, Spetzler RF, Preul MC. Josef Klingler's models of white matter tracts: influences on neuroanatomy, neurosurgery, and neuroimaging. Neurosurgery. 2011 Aug;69(2):238-52; discussion 252-4. doi: 10.1227/NEU.0b013e318214ab79. PubMed PMID: 21368687.
Martino J, da Silva-Freitas R, Caballero H, Marco de Lucas E, García-Porrero JA, Vázquez-Barquero A: Fiber dissection and diffusion tensor imaging tractography study of the temporoparietal fiber intersection area. Neurosurgery 72 (1 Suppl Operative):87–98, 2013
  • klingler_method.txt
  • Last modified: 2018/09/13 23:28
  • by administrador