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The standard for generalized epilepsies (GE) monotherapy in treatment is valproic acid (VPA) and lamotrigine (LTG) has been proposed as an alternative to VPA.

A meta-analysis suggests that VPA appears to be a better choice in controlling seizure following generalized epilepsy (GE). However, therapy should be switched to alternative monotherapy if an adequate trial of VPA monotherapy is not effective and intolerable, especially in young women 1).

Tang L, Ge L, Wu W, Yang X, Rui P, Wu Y, Yu W, Wang X. Lamotrigine versus valproic acid monotherapy for generalised epilepsy: A meta-analysis of comparative studies. Seizure. 2017 Aug 12;51:95-101. doi: 10.1016/j.seizure.2017.08.001. [Epub ahead of print] Review. PubMed PMID: 28826049.
lamotrigine.txt · Last modified: 2017/08/22 13:19 by administrador