Laser-Evoked Potentials

Laser-evoked potentials (LEPs) are among the reliable neurophysiological tools to investigate patients with neuropathic pain, as they can provide an objective account of the functional status of thermo nociceptive pathways. The goal of a case-control study of a single medical center in Belgium was to explore the functioning of the nociceptive afferent pathways by examining LEPs in patients with chronic whiplash-associated disorders (cWAD), patients with chronic fatigue syndrome (CFS), and healthy controls (HCs).

The LEPs of 21 patients with cWAD, 19 patients with CFS, and 18 HCs were analyzed in this study.

All participants received brief nociceptive CO2 laser stimuli applied to the dorsum of the left hand and left foot while brain activity was recorded with a 32-channel electroencephalogram (EEG). LEP signals and transient power modulations were compared between patient groups and HCs.

No between-group differences were found for stimulus intensity, which was supraliminal for Aδ fibers. The amplitudes and latencies of LEP wave components N1, N2, and P2 in patients with cWAD and CFS were statistically similar to those of HCs. There were no significant differences between the time-frequency maps of EEG oscillation amplitude between HCs and both patient populations.

EEG responses of heat-sensitive Aδ fibers in patients with cWAD and CFS revealed no significant differences from the responses of HCs. These findings thus do not support a state of generalized central nervous system hyperexcitability in those patients 1).

2: Linde LD, Haefeli J, Jutzeler CR, Rosner J, McDougall J, Curt A, Kramer JLK. Contact Heat Evoked Potentials Are Responsive to Peripheral Sensitization: Requisite Stimulation Parameters. Front Hum Neurosci. 2020 Jan 10;13:459. doi: 10.3389/fnhum.2019.00459. eCollection 2019. PubMed PMID: 31998104; PubMed Central PMCID: PMC6966714.

3: Böhm M, Chung DY, Gómez CA, Qin T, Takizawa T, Sadeghian H, Sugimoto K, Sakadžić S, Yaseen MA, Ayata C. Neurovascular coupling during optogenetic functional activation: Local and remote stimulus-response characteristics, and uncoupling by spreading depression. J Cereb Blood Flow Metab. 2020 Apr;40(4):808-822. doi: 10.1177/0271678×19845934. Epub 2019 May 7. PubMed PMID: 31063009.

4: Morgalla MH, de Barros Filho MF, Chander BS, Soekadar SR, Tatagiba M, Lepski G. Neurophysiological Effects of Dorsal Root Ganglion Stimulation (DRGS) in Pain Processing at the Cortical Level. Neuromodulation. 2019 Jan;22(1):36-43. doi: 10.1111/ner.12900. Epub 2018 Dec 18. PubMed PMID: 30561852.

5: Lehner KR, Yeagle EM, Argyelan M, Klimaj Z, Du V, Megevand P, Hwang ST, Mehta AD. Validation of corpus callosotomy after laser interstitial thermal therapy: a multimodal approach. J Neurosurg. 2018 Nov 1:1-11. doi: 10.3171/2018.4.JNS172588. [Epub ahead of print] PubMed PMID: 30497188.

6: Lenoir C, Jankovski A, Mouraux A. Anodal Transcutaneous Spinal Direct Current Stimulation (tsDCS) Selectively Inhibits the Synaptic Efficacy of Nociceptive Transmission at Spinal Cord Level. Neuroscience. 2018 Nov 21;393:150-163. doi: 10.1016/j.neuroscience.2018.10.007. Epub 2018 Oct 12. PubMed PMID: 30321585; PubMed Central PMCID: PMC6364802.

7: Severino R, Severino P. Cervical intramedullary spinal cord lipoma. Surg Neurol Int. 2017 Oct 24;8:255. doi: 10.4103/sni.sni_257_17. eCollection 2017. PubMed PMID: 29184706; PubMed Central PMCID: PMC5680661.

8: Hüllemann P, von der Brelie C, Manthey G, Düsterhöft J, Helmers AK, Synowitz M, Gierthmühlen J, Baron R. Laser-evoked potentials in painful radiculopathy. Clin Neurophysiol. 2017 Nov;128(11):2292-2299. doi: 10.1016/j.clinph.2017.09.100. Epub 2017 Sep 28. PubMed PMID: 29032189.

9: La Cesa S, Di Stefano G, Leone C, Pepe A, Galosi E, Alu F, Fasolino A, Cruccu G, Valeriani M, Truini A. Skin denervation does not alter cortical potentials to surface concentric electrode stimulation: A comparison with laser evoked potentials and contact heat evoked potentials. Eur J Pain. 2018 Jan;22(1):161-169. doi: 10.1002/ejp.1112. Epub 2017 Sep 12. PubMed PMID: 28898491.

10: Schmitz E, Bischoff B, Wolf D, Schmitt HJ, Eyupoglu IY, Roessler K, Buchfelder M, Sommer B. Intraoperative Vascular Neuromonitoring in Patients with Subarachnoid Hemorrhage: A Pilot Study Using Combined Laser-Doppler Spectrophotometry. World Neurosurg. 2017 Nov;107:542-548. doi: 10.1016/j.wneu.2017.08.011. Epub 2017 Aug 9. PubMed PMID: 28803174.

11: André-Obadia N, Mauguière F. [Electrophysiological testing in spinal cord tumors]. Neurochirurgie. 2017 Nov;63(5):356-365. doi: 10.1016/j.neuchi.2016.06.003. Epub 2017 Feb 1. Review. French. PubMed PMID: 28161015.

12: Hüllemann P, von der Brelie C, Manthey G, Düsterhöft J, Helmers AK, Synowitz M, Baron R. Reduced laser-evoked potential habituation detects abnormal central pain processing in painful radiculopathy patients. Eur J Pain. 2017 May;21(5):918-926. doi: 10.1002/ejp.994. Epub 2017 Jan 20. PubMed PMID: 28106318.

13: Chien JH, Colloca L, Korzeniewska A, Cheng JJ, Campbell CM, Hillis AE, Lenz FA. Oscillatory EEG activity induced by conditioning stimuli during fear conditioning reflects Salience and Valence of these stimuli more than Expectancy. Neuroscience. 2017 Mar 27;346:81-93. doi: 10.1016/j.neuroscience.2016.12.047. Epub 2017 Jan 8. PubMed PMID: 28077278; PubMed Central PMCID: PMC5426483.

14: Pommier B, Créac'h C, Beauvieux V, Nuti C, Vassal F, Peyron R. Robot-guided neuronavigated rTMS as an alternative therapy for central (neuropathic) pain: Clinical experience and long-term follow-up. Eur J Pain. 2016 Jul;20(6):907-16. doi: 10.1002/ejp.815. Epub 2016 Jan 13. PubMed PMID: 26765799.

15: Dusch M, van der Ham J, Weinkauf B, Benrath J, Rukwied R, Ringkamp M, Schmelz M, Treede RD, Baumgärtner U. Laser-evoked potentials mediated by mechano-insensitive nociceptors in human skin. Eur J Pain. 2016 May;20(5):845-54. doi: 10.1002/ejp.810. Epub 2015 Oct 22. PubMed PMID: 26492533.

16: Liu CC, Chien JH, Chang YW, Kim JH, Anderson WS, Lenz FA. Functional role of induced gamma oscillatory responses in processing noxious and innocuous sensory events in humans. Neuroscience. 2015 Dec 3;310:389-400. doi: 10.1016/j.neuroscience.2015.09.047. Epub 2015 Sep 25. PubMed PMID: 26408986; PubMed Central PMCID: PMC5675836.

17: Liu YH, Liao LD, Tan SSH, Kwon KY, Ling JM, Bandla A, Shih YI, Tan ETW, Li W, Ng WH, Lai HY, Chen YY, Thakor NV. Assessment of neurovascular dynamics during transient ischemic attack by the novel integration of micro-electrocorticography electrode array with functional photoacoustic microscopy. Neurobiol Dis. 2015 Oct;82:455-465. doi: 10.1016/j.nbd.2015.06.019. Epub 2015 Jul 3. PubMed PMID: 26149348.

18: Plazier M, Ost J, Snijders E, Gilbers M, Vancamp T, De Ridder D, Vanneste S. Laser-Evoked Potentials in Fibromyalgia: The Influence of Greater Occipital Nerve Stimulation on Cerebral Pain Processing. Neuromodulation. 2015 Jul;18(5):376-83. doi: 10.1111/ner.12310. Epub 2015 May 21. PubMed PMID: 25996805.

19: Kim JH, Chien JH, Liu CC, Lenz FA. Painful cutaneous laser stimuli induce event-related gamma-band activity in the lateral thalamus of humans. J Neurophysiol. 2015 Mar 1;113(5):1564-73. doi: 10.1152/jn.00778.2014. Epub 2014 Dec 10. PubMed PMID: 25505116; PubMed Central PMCID: PMC4346717.

20: Chien JH, Liu CC, Kim JH, Markman TM, Lenz FA. Painful cutaneous laser stimuli induce event-related oscillatory EEG activities that are different from those induced by nonpainful electrical stimuli. J Neurophysiol. 2014 Aug 15;112(4):824-33. doi: 10.1152/jn.00209.2014. Epub 2014 May 21. PubMed PMID: 24848464; PubMed Central PMCID: PMC4122748.

21: Ristić D, Ellrich J. Innocuous peripheral nerve stimulation shifts stimulus-response function of painful laser stimulation in man. Neuromodulation. 2014 Oct;17(7):686-94; discussion 694-5. doi: 10.1111/ner.12133. Epub 2013 Nov 15. PubMed PMID: 24237769.

22: Ogawa Y, Nakagawa A, Washio T, Arafune T, Tominaga T. Tissue dissection before direct manipulation to the pathology with pulsed laser-induced liquid jet system in skull base surgery–preservation of fine vessels and maintained optic nerve function. Acta Neurochir (Wien). 2013 Oct;155(10):1879-86. doi: 10.1007/s00701-013-1817-7. Epub 2013 Jul 20. PubMed PMID: 23873124.

23: Frot M, Magnin M, Mauguière F, Garcia-Larrea L. Cortical representation of pain in primary sensory-motor areas (S1/M1)–a study using intracortical recordings in humans. Hum Brain Mapp. 2013 Oct;34(10):2655-68. doi: 10.1002/hbm.22097. Epub 2012 Jun 15. PubMed PMID: 22706963.

24: Bacigaluppi S, Fontanella M, Manninen P, Ducati A, Tredici G, Gentili F. Monitoring techniques for prevention of procedure-related ischemic damage in aneurysm surgery. World Neurosurg. 2012 Sep-Oct;78(3-4):276-88. doi: 10.1016/j.wneu.2011.11.034. Epub 2011 Nov 29. Review. PubMed PMID: 22381314.

25: Liu CC, Crone NE, Franaszczuk PJ, Cheng DT, Schretlen DS, Lenz FA. Fear conditioning is associated with dynamic directed functional interactions between and within the human amygdala, hippocampus, and frontal lobe. Neuroscience. 2011 Aug 25;189:359-69. doi: 10.1016/j.neuroscience.2011.05.067. Epub 2011 Jun 12. PubMed PMID: 21664438; PubMed Central PMCID: PMC3150454.

26: Kawamata T, Kawashima A, Yamaguchi K, Hori T, Okada Y. Usefulness of intraoperative laser Doppler flowmetry and thermography to predict a risk of postoperative hyperperfusion after superficial temporal artery-middle cerebral artery bypass for moyamoya disease. Neurosurg Rev. 2011 Jul;34(3):355-62; discussion 362. doi: 10.1007/s10143-011-0331-8. Epub 2011 Jun 4. PubMed PMID: 21643682.

27: Liu CC, Shi CQ, Franaszczuk PJ, Crone NE, Schretlen D, Ohara S, Lenz FA. Painful laser stimuli induce directed functional interactions within and between the human amygdala and hippocampus. Neuroscience. 2011 Mar 31;178:208-17. doi: 10.1016/j.neuroscience.2011.01.029. Epub 2011 Jan 20. PubMed PMID: 21256929; PubMed Central PMCID: PMC3048957.

28: Liu CC, Ohara S, Franaszczuk PJ, Lenz FA. Attention to painful cutaneous laser stimuli evokes directed functional connectivity between activity recorded directly from human pain-related cortical structures. Pain. 2011 Mar;152(3):664-75. doi: 10.1016/j.pain.2010.12.016. Epub 2011 Jan 20. PubMed PMID: 21255929; PubMed Central PMCID: PMC3043083.

29: Vanzetta I, Flynn C, Ivanov AI, Bernard C, Bénar CG. Investigation of linear coupling between single-event blood flow responses and interictal discharges in a model of experimental epilepsy. J Neurophysiol. 2010 Jun;103(6):3139-52. doi: 10.1152/jn.01048.2009. Epub 2010 Mar 24. PubMed PMID: 20457851.

30: Liu CC, Ohara S, Franaszczuk P, Zagzoog N, Gallagher M, Lenz FA. Painful stimuli evoke potentials recorded from the medial temporal lobe in humans. Neuroscience. 2010 Feb 17;165(4):1402-11. doi: 10.1016/j.neuroscience.2009.11.026. Epub 2009 Nov 17. PubMed PMID: 19925853; PubMed Central PMCID: PMC2815048.

31: Englot DJ, Modi B, Mishra AM, DeSalvo M, Hyder F, Blumenfeld H. Cortical deactivation induced by subcortical network dysfunction in limbic seizures. J Neurosci. 2009 Oct 14;29(41):13006-18. doi: 10.1523/JNEUROSCI.3846-09.2009. PubMed PMID: 19828814; PubMed Central PMCID: PMC2778759.

32: Valeriani M, Truini A, Le Pera D, Insola A, Galeotti F, Petrachi C, Mazzone P, Cruccu G. Laser evoked potential recording from intracerebral deep electrodes. Clin Neurophysiol. 2009 Apr;120(4):790-5. doi: 10.1016/j.clinph.2009.02.162. Epub 2009 Mar 20. PubMed PMID: 19303809.

33: Kobayashi K, Winberry J, Liu CC, Treede RD, Lenz FA. A painful cutaneous laser stimulus evokes responses from single neurons in the human thalamic principal somatic sensory nucleus ventral caudal (Vc). J Neurophysiol. 2009 May;101(5):2210-7. doi: 10.1152/jn.91347.2008. Epub 2009 Feb 25. PubMed PMID: 19244350; PubMed Central PMCID: PMC3815208.

34: Mack KF, Leinung M, Stieve M, Lenarz T, Schwab B. Clinical feasibility test on a minimally invasive laser therapy system in microsurgery of nerves. Minim Invasive Ther Allied Technol. 2008;17(5):292-9. doi: 10.1080/13645700802274729. PubMed PMID: 18855207.

35: Royl G, Füchtemeier M, Leithner C, Megow D, Offenhauser N, Steinbrink J, Kohl-Bareis M, Dirnagl U, Lindauer U. Hypothermia effects on neurovascular coupling and cerebral metabolic rate of oxygen. Neuroimage. 2008 May 1;40(4):1523-32. doi: 10.1016/j.neuroimage.2008.01.041. Epub 2008 Feb 7. PubMed PMID: 18343160.

36: Ohara S, Crone NE, Weiss N, Kim JH, Lenz FA. Analysis of synchrony demonstrates that the presence of “pain networks” prior to a noxious stimulus can enable the perception of pain in response to that stimulus. Exp Brain Res. 2008 Feb;185(2):353-8. doi: 10.1007/s00221-008-1284-1. Epub 2008 Jan 30. PubMed PMID: 18231782.

37: Ristić D, Spangenberg P, Ellrich J. Analgesic and antinociceptive effects of peripheral nerve neurostimulation in an advanced human experimental model. Eur J Pain. 2008 May;12(4):480-90. Epub 2007 Sep 18. PubMed PMID: 17881268.

38: Ellrich J, Jung K, Ristic D, Yekta SS. Laser-evoked cortical potentials in cluster headache. Cephalalgia. 2007 Jun;27(6):510-8. Epub 2007 Apr 11. PubMed PMID: 17428300.

39: Ohara S, Anderson WS, Lawson HC, Lee HT, Lenz FA. Endogenous and exogenous modulators of potentials evoked by a painful cutaneous laser (LEPs). Acta Neurochir Suppl. 2006;99:77-9. PubMed PMID: 17370769.

40: Frot M, Magnin M, Mauguière F, Garcia-Larrea L. Human SII and posterior insula differently encode thermal laser stimuli. Cereb Cortex. 2007 Mar;17(3):610-20. Epub 2006 Apr 13. PubMed PMID: 16614165.

41: Ohara S, Crone NE, Weiss N, Lenz FA. Analysis of synchrony demonstrates 'pain networks' defined by rapidly switching, task-specific, functional connectivity between pain-related cortical structures. Pain. 2006 Aug;123(3):244-53. Epub 2006 Mar 24. PubMed PMID: 16563627.

42: Ellrich J, Lamp S. Peripheral nerve stimulation inhibits nociceptive processing: an electrophysiological study in healthy volunteers. Neuromodulation. 2005 Oct;8(4):225-32. doi: 10.1111/j.1525-1403.2005.00029.x. PubMed PMID: 22151549.

43: Burnett MG, Detre JA, Greenberg JH. Activation-flow coupling during graded cerebral ischemia. Brain Res. 2005 Jun 14;1047(1):112-8. PubMed PMID: 15893740.

44: Ohara S, Crone NE, Weiss N, Treede RD, Lenz FA. Amplitudes of laser evoked potential recorded from primary somatosensory, parasylvian and medial frontal cortex are graded with stimulus intensity. Pain. 2004 Jul;110(1-2):318-28. PubMed PMID: 15275782.

45: Ohara S, Crone NE, Weiss N, Lenz FA. Attention to a painful cutaneous laser stimulus modulates electrocorticographic event-related desynchronization in humans. Clin Neurophysiol. 2004 Jul;115(7):1641-52. PubMed PMID: 15203065.

46: Ohara S, Crone NE, Weiss N, Vogel H, Treede RD, Lenz FA. Attention to pain is processed at multiple cortical sites in man. Exp Brain Res. 2004 Jun;156(4):513-7. Epub 2004 May 4. PubMed PMID: 15127169.

47: Valeriani M, Barba C, Le Pera D, Restuccia D, Colicchio G, Tonali P, Gagliardo O, Treede RD. Different neuronal contribution to N20 somatosensory evoked potential and to CO2 laser evoked potentials: an intracerebral recording study. Clin Neurophysiol. 2004 Jan;115(1):211-6. PubMed PMID: 14706490.

48: Ohara S, Crone NE, Weiss N, Treede RD, Lenz FA. Cutaneous painful laser stimuli evoke responses recorded directly from primary somatosensory cortex in awake humans. J Neurophysiol. 2004 Jun;91(6):2734-46. Epub 2003 Nov 5. PubMed PMID: 14602841.

49: Rosengarten B, Lutz H, Hossmann KA. A control system approach for evaluating somatosensory activation by laser-Doppler flowmetry in the rat cortex. J Neurosci Methods. 2003 Nov 30;130(1):75-81. PubMed PMID: 14583406.

50: Foo H, Mason P. Discharge of raphe magnus ON and OFF cells is predictive of the motor facilitation evoked by repeated laser stimulation. J Neurosci. 2003 Mar 1;23(5):1933-40. PubMed PMID: 12629198; PubMed Central PMCID: PMC6741988.

51: Nahra H, Plaghki L. The effects of A-fiber pressure block on perception and neurophysiological correlates of brief non-painful and painful CO2 laser stimuli in humans. Eur J Pain. 2003;7(2):189-99. PubMed PMID: 12600801.

52: Frot M, Mauguière F. Dual representation of pain in the operculo-insular cortex in humans. Brain. 2003 Feb;126(Pt 2):438-50. PubMed PMID: 12538410.

53: Rochkind S, Shahar A, Amon M, Nevo Z. Transplantation of embryonal spinal cord nerve cells cultured on biodegradable microcarriers followed by low power laser irradiation for the treatment of traumatic paraplegia in rats. Neurol Res. 2002 Jun;24(4):355-60. PubMed PMID: 12069281.

54: Frot M, Garcia-Larrea L, Guénot M, Mauguière F. Responses of the supra-sylvian (SII) cortex in humans to painful and innocuous stimuli. A study using intra-cerebral recordings. Pain. 2001 Oct;94(1):65-73. PubMed PMID: 11576746.

55: Rios M, Treede R, Lee J, Lenz FA. Direct Evidence of Nociceptive Input to Human Anterior Cingulate Gyrus and Parasylvian Cortex. Curr Rev Pain. 1999;3(4):256-264. PubMed PMID: 10998681.

56: Young WF, Tuma R, O'Grady T. Intraoperative measurement of spinal cord blood flow in syringomyelia. Clin Neurol Neurosurg. 2000 Sep;102(3):119-23. PubMed PMID: 10996707.

57: Kakigi R, Hoshiyama M, Shimojo M, Naka D, Yamasaki H, Watanabe S, Xiang J, Maeda K, Lam K, Itomi K, Nakamura A. The somatosensory evoked magnetic fields. Prog Neurobiol. 2000 Aug;61(5):495-523. Review. PubMed PMID: 10748321.

58: Lenz FA, Krauss G, Treede RD, Lee JL, Boatman D, Crone N, Minahan R, Port J, Rios M. Different generators in human temporal-parasylvian cortex account for subdural laser-evoked potentials, auditory-evoked potentials, and event-related potentials. Neurosci Lett. 2000 Feb 4;279(3):153-6. PubMed PMID: 10688052.

59: Okumura A, Takenaka K, Nishimura Y, Kawaguchi M, Yamakawa H, Shinoda J, Deguchi K, Sakai N. Intra-operative optical method using intrinsic signals for localization of sensorimotor area in patients with brain tumor. Neurol Res. 1999 Sep;21(6):545-52. PubMed PMID: 10491813.

60: Lenz FA, Rios M, Chau D, Krauss GL, Zirh TA, Lesser RP. Painful stimuli evoke potentials recorded from the parasylvian cortex in humans. J Neurophysiol. 1998 Oct;80(4):2077-88. PubMed PMID: 9772262.

61: Lenz FA, Rios M, Zirh A, Chau D, Krauss G, Lesser RP. Painful stimuli evoke potentials recorded over the human anterior cingulate gyrus. J Neurophysiol. 1998 Apr;79(4):2231-4. PubMed PMID: 9535984.

62: Yamada T, Morimoto T, Nakase H, Hirabayashi H, Hiramatsu K, Sakaki T. Spinal cord blood flow and pathophysiological changes after transient spinal cord ischemia in cats. Neurosurgery. 1998 Mar;42(3):626-34. PubMed PMID: 9526997.

63: Ide R, Fukusaki M, Yamaguchi K, Matsumoto M, Ogata K, Sumikawa K. [Effect of controlled hypotension induced by prostaglandin E1 on evoked spinal cord potential and spinal cord blood flow]. Masui. 1997 Oct;46(10):1342-6. Japanese. PubMed PMID: 9369049.

64: Milhorat TH, Capocelli AL Jr, Kotzen RM, Bolognese P, Heger IM, Cottrell JE. Intramedullary pressure in syringomyelia: clinical and pathophysiological correlates of syrinx distension. Neurosurgery. 1997 Nov;41(5):1102-10. PubMed PMID: 9361064.

65: Häbler HJ, Wasner G, Bartsch T, Jänig W. Responses of rat postganglionic sympathetic vasoconstrictor neurons following blockade of nitric oxide synthesis in vivo. Neuroscience. 1997 Apr;77(3):899-909. PubMed PMID: 9070761.

66: Schmitz F, Besselmann M, Bettag M, Neubauer M, Schmitz P, Kiwit J, Kunesch E. Somatosensory evoked potentials modified by laser-induced lesions of the rat cortex. Behav Brain Res. 1997 Mar;84(1-2):161-6. PubMed PMID: 9079782.

67: Milhorat TH, Kotzen RM, Capocelli AL Jr, Bolognese P, Bendo AA, Cottrell JE. Intraoperative improvement of somatosensory evoked potentials and local spinal cord blood flow in patients with syringomyelia. J Neurosurg Anesthesiol. 1996 Jul;8(3):208-15. PubMed PMID: 8803832.

68: Zaric D, Hallgren S, Leissner L, Nydahl PA, Adel SO, Philipson L, Samuelsson L, Leissner P, Axelsson K. Evaluation of epidural sensory block by thermal stimulation, laser stimulation, and recording of somatosensory evoked potentials. Reg Anesth. 1996 Mar-Apr;21(2):124-38. PubMed PMID: 8829405.

69: Hayashi N, Endo S, Kurimoto M, Nishijo H, Ono T, Takaku A. Functional image-guided neurosurgical simulation system using computerized three-dimensional graphics and dipole tracing. Neurosurgery. 1995 Oct;37(4):694-703. PubMed PMID: 8559298.

70: Khullar SM, Brodin P, Messelt EB, Haanaes HR. The effects of low level laser treatment on recovery of nerve conduction and motor function after compression injury in the rat sciatic nerve. Eur J Oral Sci. 1995 Oct;103(5):299-305. PubMed PMID: 8521121.

71: Guo J, Liao JJ, Preston JK, Batjer HH. A canine model of acute hindbrain ischemia and reperfusion. Neurosurgery. 1995 May;36(5):986-92; discussion 992-3. PubMed PMID: 7791992.

72: Ohba S, Uozumi T, Arita K, Kurisu K, Nakahara T, Kuwabara S. Changes of motor evoked potentials in global and focal ischemic models of cats. Hiroshima J Med Sci. 1995 Mar;44(1):1-5. PubMed PMID: 7622403.

73: Colak A, Nurlu G, Açikgöz B, Ozcan OE. Efficacy of high dose amino acid solution on spinal cord injury induced by focal Nd:YAG laser irradiation. Acta Neurochir (Wien). 1995;133(1-2):73-9. PubMed PMID: 8561042.

74: Ungersböck K, Tenckhoff D, Heimann A, Wagner W, Kempski OS. Transcranial Doppler and cortical microcirculation at increased intracranial pressure and during the Cushing response: an experimental study on rabbits. Neurosurgery. 1995 Jan;36(1):147-56; discussion 156-7. PubMed PMID: 7708151.

75: Colak A, Nurlu G, Açikgöz B, Ozcan OE, Aydim E. A new experimental model: for further investigation of the secondary changes following spinal cord injury. J Neurosurg Sci. 1994 Jun;38(2):111-6. PubMed PMID: 7891191.

76: Chen TC, Rabb C, Apuzzo ML. Complex technical methodologies and their applications in the surgery of intracranial meningiomas. Neurosurg Clin N Am. 1994 Apr;5(2):261-81. Review. PubMed PMID: 8032226.

77: Young WF, Rosenwasser RH, Vasthare US, Tuma RF. Preservation of post-compression spinal cord function by infusion of hypertonic saline. J Neurosurg Anesthesiol. 1994 Apr;6(2):122-7. PubMed PMID: 8012171.

78: Lal AP, Joseph T, Chandi SM, Pant B. Facial neurorrhaphy with autologous sural nerve graft using the CO2 laser in a primate model. Neurosurgery. 1993 Jun;32(6):1011-4; discussion 1014. PubMed PMID: 8392145.

79: Andrews RJ, Bringas JR, Alonzo G, Salamat MS, Khoshyomn S, Gluck DS. Corpus callosotomy effects on cerebral blood flow and evoked potentials (transcallosal diaschisis). Neurosci Lett. 1993 May 14;154(1-2):9-12. PubMed PMID: 8361654.

80: Gökalp HZ, Egemen N, Culcuoglu A, Naderi S, Zorlutuna A. The use of Nd:YAG laser in pituitary surgery and evaluation of visual function by visual evoked potential (VEP). Neurosurg Rev. 1992;15(3):193-7. PubMed PMID: 1407607.

81: Arendt-Nielsen L, Bjerring P, Dahl JB. A quantitative double-blind evaluation of the antinociceptive effects of perineurally administered morphine compared with lidocaine. Acta Anaesthesiol Scand. 1991 Jan;35(1):24-9. PubMed PMID: 2006595.

82: Treede RD, Meyer RA, Campbell JN. Comparison of heat and mechanical receptive fields of cutaneous C-fiber nociceptors in monkey. J Neurophysiol. 1990 Nov;64(5):1502-13. PubMed PMID: 2283538.

83: Wilken B, Aksu F, vd Lühe C, Reusche E, Arnold H. [Intraspinal astrocytoma in a 3-year-old girl]. Monatsschr Kinderheilkd. 1990 Jan;138(1):38-40. German. PubMed PMID: 2314404.

84: Kakigi R, Shibasaki H, Ikeda A. Pain-related somatosensory evoked potentials following CO2 laser stimulation in man. Electroencephalogr Clin Neurophysiol. 1989 Mar-Apr;74(2):139-46. PubMed PMID: 2465889.

85: de la Torre JC, Karaca M, Merali Z, Fortin T, Richard M. Laser or razor? A novel experimental peripheral nerve repair technique. Neurosurgery. 1988 Mar;22(3):531-9. PubMed PMID: 3362320.

86: Long RR, Wirth FP. Reversible somatosensory evoked potential changes with neodymium: yttrium-aluminum-garnet laser use. Neurosurgery. 1987 Oct;21(4):465-7. PubMed PMID: 3683778.

87: Mizoi K, Suzuki J, Abiko H, Ogasawara K, Oba M, Yoshimoto T. Experimental study on the reversibility of cerebral ischemia. Residual blood flow and duration of ischemia. Acta Neurochir (Wien). 1987;88(3-4):126-34. PubMed PMID: 3687499.

88: Burke LP, Rovin RA, Cerullo LJ. Evoked responses and the laser. Neurosurgery. 1984 Oct;15(4):608-9. PubMed PMID: 6493475.

89: Salcman M, Mayer R. Intramedullary subependymoma of the cervical spinal cord: case report. Neurosurgery. 1984 May;14(5):608-11. PubMed PMID: 6728174.

90: Yoshii Y, Egashira T, Maki Y. Use of evoked responses to measure laser photoradiation tissue effects. Neurosurgery. 1984 Feb;14(2):131-4. PubMed PMID: 6709134.

91: Hempel FG. Rabbit visual potentials after laser photocoagulation. Invest Ophthalmol. 1971 Sep;10(9):639-49. PubMed PMID: 4937655.

Goudman L, Daenen L, Mouraux A, Nijs J, Cras P, Roussel N, Moens M, Coppieters I, Huysmans E, De Kooning M. Processing of Laser-Evoked Potentials in Patients with Chronic Whiplash-Associated Disorders, Chronic Fatigue Syndrome, and Healthy Controls: A Case-Control Study. Pain Med. 2020 Apr 14. pii: pnaa068. doi: 10.1093/pm/pnaa068. [Epub ahead of print] PubMed PMID: 32289826.
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