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Loss of one arm of a hybrid chromosome is called loss of heterozygosity (LOH) for that chromosome region. LOH in 1p & 19q occurs as a result of unbalanced whole-arm translocations between chromosome 1 & chromosome 19, 1) which occurs early in the pathogenesis of oligodendrogliomas.

Jenkins RB, Blair H, Ballman KV, et al. A t(1;19) (q10;p10) mediates the combined deletions of 1p and 19q and predicts a better prognosis of patients with oligodendroglioma. Cancer Res. 2006; 66: 9852–9861
loss_of_heterozygosity.txt · Last modified: 2019/10/16 23:14 by administrador