Low-grade glioma

WHO grade 1 glioma

see also WHO grade 2 glioma

see Astrocytoma IDH-mutant

A diffuse astrocytoma with a mutation in either the IDH1 or IDH2 gene. Use of the former term “low-grade glioma” is discouraged.

Rapidly emerging and evolving molecular glioma classifications have influenced treatment paradigms. Importantly, low-grade gliomas can be classified on the basis of IDH mutation status, whereby low-grade astrocytomas harbor the IDH mutation, while oligodendrogliomas are defined by both IDH mutant status and 1p/19q co-deletion. Given the importance of molecular classification for diagnosis, treatment planning, and prognostication, tissue samples are necessary for proper management. Literature supports improved overall survival and outcomes with increased extent of resection for low-grade glioma. Awake craniotomies and resection of insular low-grade gliomas both have been demonstrated as safe and improve outcomes for patients with lesions located in eloquent areas. Given the younger age at diagnosis of these lesions compared with higher-grade gliomas, fertility, fertility preservation, and potential malignant transformation should be discussed with patients of childbearing age 1).

Giantini-Larsen AM, Pannullo S, Juthani RG. Challenges in the Diagnosis and Management of Low-Grade Gliomas. World Neurosurg. 2022 Oct;166:313-320. doi: 10.1016/j.wneu.2022.06.074. PMID: 36192863.
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