Pituitary carcinomas are exceedingly rare. Extremely infrequently acromegaly occurs as a result of ectopic secretion of growth hormone releasing hormone (GHRH) from a peripheral neuroendocrine tumour, or from excessive hypothalamic GHRH secretio. Approximately 5% of cases are associated with familial syndromes, most commonly multiple endocrine neoplasia type 1 (MEN1) syndrome, but also McCune-Albright syndrome, familial acromegaly, Carney’s syndrome and Familial Isolated pituitary neuroendocrine tumor (FIPA) 1).

Carroll PV, Jenkins PJ. Acromegaly. In: De Groot LJ, Beck-Peccoz P, Chrousos G, Dungan K, Grossman A, Hershman JM, Koch C, McLachlan R, New M, Rebar R, Singer F, Vinik A, Weickert MO, editors. Endotext [Internet]. South Dartmouth (MA):, Inc.; 2000-. Available from PubMed PMID: 25905322.
  • mccune-albright_syndrome.txt
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