The term encompasses five structures:
This system (a) is principally concerned with memory, (b) operates with neocortex to establish and maintain long-term memory, and c ultimately, through a process of consolidation, becomes independent of long-term memory, though questions remain about the role of perirhinal and parahippocampal cortices in this process and about spatial memory in rodents. Data from neurophysiology, neuroimaging, and neuroanatomy point to a division of labor within the medial temporal lobe. However, the available data do not support simple dichotomies between the functions of the hippocampus and the adjacent medial temporal cortex, such as associative versus nonassociative memory, episodic versus semantic memory, and recollection versus familiarity 1).
Not only is the knowledge of these relations useful to angiographically characterize the mesial temporal region, but it has also proven to be of extreme value during microsurgeries involving this region as applied to amygdalohippocampectomy 2).
Statistical analysis demonstrated that the left medial temporal lobe and right anterior temporal lobe were specifically associated with high expression of mutant p53. Kaplan-Meier curves showed that tumors located in these regions were associated with significantly worse progression free survival compared with tumors occurring elsewhere, providing new evidence that genetic changes during cancer may have anatomic specificity. Additionally, suggests that tumor location identified on structural MR images could potentially be used for customized presurgical outcome prediction 3).