mesial_temporal_lobe_epilepsy_case_series

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mesial_temporal_lobe_epilepsy_case_series [2022/10/05 17:05] – created - external edit 127.0.0.1mesial_temporal_lobe_epilepsy_case_series [2023/04/12 23:53] (current) – administrador
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 ====== Mesial temporal lobe epilepsy case series ====== ====== Mesial temporal lobe epilepsy case series ======
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 +===== 2023 =====
 +From January 2012 to December 2019, the MTLE patients with surgical failure were reviewed, and all patients underwent SEEG-guided reoperation. The epileptogenic network was quantified by calculating FC indicators, including phase slope index (PSI), mutual information (MI) strength, imaginary coherence (icoh), and Granger causality.
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 +Results: Ten patients with 13 seizures were included in the analysis, and 7 of them achived a favorable outcomes after the SEEG-guided reoperation. The surgical zone (SZ) with favorable prognosis showed greater outward information flow than the nonSZ, while the SZ with unfavorable prognosis showed greater inward information flow. The recurrent patients with favorable prognosis had a strong connectivity between the posterior hippocampus, temporal neocortex and insula, while the patients with unfavorable prognosis showed a strong functional connectivity between insula and temporal-parietal-occipital junction. The power spectrum of patients with favorable prognosis was significantly lower than that of patients with unfavorable prognosis, especially showing a more oscillation power of low frequency.
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 +Significance: The SEEG-guided reoperation could achieve favorable seizure control outcomes for recurrent patients.The FCs were a potential indicator to help construct the temporal epileptic network and predictor for the reoperative prognosis in the recurrent patients
 +((Xu K, Yang X, Zhou J, Guan Y, Zhao M, Wang M, Wang J, Li T, Wang X, Luan G. SEEG-based reevaluation of epileptogenic networks and the predictive role for reoperation in MTLE patients with surgical failure. Epilepsia Open. 2023 Apr 12. doi: 10.1002/epi4.12743. Epub ahead of print. PMID: 37043173.)).
 ===== 2022 ===== ===== 2022 =====
 Twenty-seven mTLE patients who underwent LiTT at our institution were analyzed. One-year seizure outcome was categorized as complete seizure freedom (ILAE Class I) and residual seizures (ILAE Class II-VI). Volumes of the hippocampus and amygdala were segmented from the preoperative T1 MRI sequence. Spatially distinct hyperintensity clusters were identified in the preoperative [[ADC]] map. The proportion of cluster volume and number ablated were associated with seizure outcomes. Twenty-seven mTLE patients who underwent LiTT at our institution were analyzed. One-year seizure outcome was categorized as complete seizure freedom (ILAE Class I) and residual seizures (ILAE Class II-VI). Volumes of the hippocampus and amygdala were segmented from the preoperative T1 MRI sequence. Spatially distinct hyperintensity clusters were identified in the preoperative [[ADC]] map. The proportion of cluster volume and number ablated were associated with seizure outcomes.
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