mesial_temporal_lobe_epilepsy_case_series

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mesial_temporal_lobe_epilepsy_case_series [2022/10/05 17:04] – [2016] administradormesial_temporal_lobe_epilepsy_case_series [2022/10/05 17:05] (current) administrador
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 ====== Mesial temporal lobe epilepsy case series ====== ====== Mesial temporal lobe epilepsy case series ======
 ===== 2022 ===== ===== 2022 =====
-Twenty-seven mTLE patients who underwent LiTT at our institution were analyzed. One-year seizure outcome was categorized as complete seizure freedom (ILAE Class I) and residual seizures (ILAE Class II-VI). Volumes of the hippocampus and amygdala were segmented from the preoperative T1 MRI sequence. Spatially distinct hyperintensity clusters were identified in the preoperative ADC map. The proportion of cluster volume and number ablated were associated with seizure outcomes.+Twenty-seven mTLE patients who underwent LiTT at our institution were analyzed. One-year seizure outcome was categorized as complete seizure freedom (ILAE Class I) and residual seizures (ILAE Class II-VI). Volumes of the hippocampus and amygdala were segmented from the preoperative T1 MRI sequence. Spatially distinct hyperintensity clusters were identified in the preoperative [[ADC]] map. The proportion of cluster volume and number ablated were associated with seizure outcomes.
  
 The mean age at surgery was 37.5 years and the mean follow-up duration was 1.9 years. Proportions of hippocampal cluster volume (p = 0.013) and number (p = 0.03) ablated were significantly higher in patients with seizure freedom. For amygdala clusters, the proportion of cluster number ablated was significantly associated with seizure outcome (p = 0.026). In the combined amygdalohippocampal complex, ablation of amygdalohippocampal clusters reliably predicted seizure outcome by their volume ablated. (AUC = 0.7670, p = 0.02). The mean age at surgery was 37.5 years and the mean follow-up duration was 1.9 years. Proportions of hippocampal cluster volume (p = 0.013) and number (p = 0.03) ablated were significantly higher in patients with seizure freedom. For amygdala clusters, the proportion of cluster number ablated was significantly associated with seizure outcome (p = 0.026). In the combined amygdalohippocampal complex, ablation of amygdalohippocampal clusters reliably predicted seizure outcome by their volume ablated. (AUC = 0.7670, p = 0.02).
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