MGMT promoter methylation
O6 methylguanine DNA methyltransferase (also known as AGT, MGMT or AGAT) biomarker is a protein that in humans is encoded by the O6-methylguanine DNA methyltransferase (MGMT) gene.
It is crucial for genome stability. It repairs the naturally occurring mutagenic DNA lesion O6-methylguanine back to guanine and prevents mismatch and errors during DNA replication and transcription. Accordingly, loss of MGMT increases the carcinogenic risk in mice after exposure to alkylating agents.
It repairs the naturally occurring mutagenic DNA lesion O6-methylguanine back to guanine and prevents mismatch and errors during DNA replication and transcription. Accordingly, loss of MGMT increases the carcinogenic risk in mice after exposure to alkylating agents.