MGMT promoter methylation

O6-methylguanine DNA methyltransferase (MGMT) is crucial for genome stability. It repairs the naturally occurring mutagenic DNA lesion O6-methylguanine back to guanine and prevents mismatch and errors during DNA replication and transcription. Accordingly, loss of MGMT increases the carcinogenic risk in mice after exposure to alkylating agents.

see Unmethylated MGMT promoter.

MGMT promoter methylation in Glioblastoma.

  • mgmt_promoter_methylation.txt
  • Last modified: 2021/06/07 11:07
  • by administrador