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necrosis

Necrosis

Necrosis (from the Greek νέκρωσις “death, the stage of dying, the act of killing” from νεκρός “dead”) is a form of cell injury that results in the premature death of cells in living tissue by autolysis.

Necrosis is caused by factors external to the cell or tissue, such as infection, toxins, or trauma that result in the unregulated digestion of cell components.

see Radiation induced necrosis.

In contrast, apoptosis is a naturally occurring programmed and targeted cause of cellular death. While apoptosis often provides beneficial effects to the organism, necrosis is almost always detrimental and can be fatal.

Necrosis is associated with complement activation in medulloblastoma. Medulloblastoma cells express C3aR, and siRNA-mediated knockdown of C3aR inhibits proliferation of these cells in vitro 1).

1)
Maurer AJ, Bonney PA, Toho LC, Glenn CA, Agarwal S, Battiste JD, Fung KM, Sughrue ME. Tumor necrosis-initiated complement activation stimulates proliferation of medulloblastoma cells. Inflamm Res. 2015 Jan 22. [Epub ahead of print] PubMed PMID: 25603857.
necrosis.txt · Last modified: 2015/11/07 11:13 (external edit)