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neurodegeneration

Neurodegeneration

Is the umbrella term for the progressive loss of structure or function of neurons, including death of neurons. Many neurodegenerative diseases including ALS, Parkinson’s, Alzheimer’s, and Huntington’s occur as a result of neurodegenerative processes. As research progresses, many similarities appear that relate these diseases to one another on a sub-cellular level. Discovering these similarities offers hope for therapeutic advances that could ameliorate many diseases simultaneously. There are many parallels between different neurodegenerative disorders including atypical protein assemblies as well as induced cell death.

Neurodegeneration can be found in many different levels of neuronal circuitry ranging from molecular to systemic.

Spatially distinct neurodegeneration is associated with β-amyloid (Aβ) and tau protein pathology in preclinical Alzheimer disease (AD). Aβ deposition and AD signature cortical atrophy independently affect cognition in cognitively normal (CN) older individuals 1).


New findings in the field of neurodegeneration and psychosis parallel new directions in the field of neurodegeneration in general. More specifically, we have seen a shift in focus to issues highlighting the role of sex, biomarkers, translation to other disorders, and therapeutics 2).

1)
Wang L, Benzinger TL, Hassenstab J, Blazey T, Owen C, Liu J, Fagan AM, Morris JC, Ances BM. Spatially distinct atrophy is linked to β-amyloid and tau in preclinical Alzheimer disease. Neurology. 2015 Feb 25. pii: 10.1212/WNL.0000000000001401. [Epub ahead of print] PubMed PMID: 25716355.
2)
Karameh WK, Murari G, Schweizer TA, Munoz DG, Fischer CE. Psychosis in neurodegenerative disorders: recent developments. Curr Opin Psychiatry. 2018 Dec 5. doi: 10.1097/YCO.0000000000000476. [Epub ahead of print] PubMed PMID: 30520740.
neurodegeneration.txt · Last modified: 2018/12/09 12:02 by administrador