Non-aneurysmal subarachnoid hemorrhage

From 2006 to 2017, 154 patients suffering from non-aneurysmal SAH were admitted to the Department of Neurosurgery, Rheinische Friedrich-Wilhelms-University Bonn, Germany.

Patients were stratified according to the distribution of cisternal blood into patients with perimesencephalic subarachnoid hemorrhage (pSAH) versus non-perimesencephalic SAH (npSAH). C reactive protein (CRP) and white blood cells (WBC) assessments were performed within 24 h of admission as part of routine laboratory workup. Outcome was assessed according to the modified Rankin Scale (mRS) after 6 months and stratified into favorable (mRS 0-2) vs. unfavorable (mRS 3-6).

The multivariate regression analysis revealed “CRP > 5 mg/l” (p = 0.004, OR 143.7), “WBC count > 12.1 G/l” (p = 0.006, OR 47.8), “presence of IVH” (p = 0.02, OR 13.5), “poor-grade SAH” (p = 0.01, OR 45.2) and “presence of CVS” (p = 0.003, OR 149.9) as independently associated with unfavorable outcome in patients with non-aneurysmal SAH.

Elevated C-reactive protein and WBC count at admission were associated with unfavorable outcome after non-aneurysmal SAH 1).

Schuss P, Hadjiathanasiou A, Brandecker S, Güresir Á, Vatter H, Güresir E. Elevated C-reactive protein and white blood cell count at admission predict functional outcome after non-aneurysmal subarachnoid hemorrhage. J Neurol. 2018 Oct 13. doi: 10.1007/s00415-018-9091-5. [Epub ahead of print] PubMed PMID: 30317466.
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