non-small_cell_lung_cancer

Non-small cell lung cancer

Non-small cell lung cancer (NSCLC) is any type of epithelial lung cancer other than Small-cell lung cancer (SCLC).

Includes: adenocarcinoma (the most common NSCLC), large cell, squamous cell, bronchoalveolar.

Lung cancer continues to be a leading cause of cancer-related death worldwide, with non-Small-cell lung cancer (NSCLC) accounting for more than 80% of lung cancer cases.

Epidemiology

Lung cancer is the leading cause of cancer mortality worldwide, accounting for 1.38 million annual deaths, representing 18.2% of total deaths from cancer 1).

Non-Small-cell lung cancer (NSCLC) account for more than 80% of lung cancer cases.

Among those, approximately 7.4% of non-Small-cell lung cancer (NSCLC) patients will have brain metastases (BM) at presentation 2) , and between 20–40% of Non-Small-cell lung cancer (NSCLC) patients will develop intracranial metastases 3) 4).

Classification

see Non-Small-cell lung cancer classification.

Diagnosis

Non-Small-cell lung cancer Diagnosis.

Complications

Non-Small-cell lung cancer metastases

Non-Small cell lung cancer metastases

Treatment

see Non-Small cell lung cancer treatment.

Outcome

see Non-Small cell lung cancer outcome.

Case series

Non-Small-cell lung cancer case series.

1)
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90. doi: 10.3322/caac.20107. Epub 2011 Feb 4. Erratum in: CA Cancer J Clin. 2011 Mar-Apr;61(2):134. PubMed PMID: 21296855.
2)
Schuette W. Treatment of brain metastases from lung cancer: chemotherapy. Lung Cancer. 2004 Aug;45 Suppl 2:S253-7. Review. PubMed PMID: 15552807.
3)
Brower JV, Robins HI. Erlotinib for the treatment of brain metastases in non-Small-cell lung cancer. Expert Opin Pharmacother. 2016;17(7):1013-21. doi: 10.1517/14656566.2016.1165206. Epub 2016 Mar 30. Review. PubMed PMID: 26967582.
4)
Zhao J, Chen M, Zhong W, Zhang L, Li L, Xiao Y, Nie L, Hu P, Wang M. Cerebrospinal fluid concentrations of gefitinib in patients with lung adenocarcinoma. Clin Lung Cancer. 2013 Mar;14(2):188-93. doi: 10.1016/j.cllc.2012.06.004. Epub 2012 Jul 28. PubMed PMID: 22846582.
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