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Non Hodgkin Primary central nervous system lymphoma

For general imaging appearances on CT and MRI consider:

Secondary CNS lymphoma: indistinguishable on imaging, however, it tends to involve more leptomeninges (~2/3 of cases)

Cerebral toxoplasmosis:

Toxoplasmosis does not exhibit subependymal spread

More likely to lie in basal ganglia, corticomedullary junction

CNS lymphoma is thallium/PET avid, whereas toxoplasmosis is not.

Topographic analysis using voxel-based morphometry (VBM) provides useful information for differentiating PCNSL from GBM 1).

Butterfly glioma/Glioblastoma

more commonly centrally necrotic

more commonly demonstrates evidence of haemorrhage

tumefactive MS/ADEM

cerebral abscess

peripheral enhancement of PCNSL is thicker

Central restricted diffusion

Neurosarcoidosis 2).

Yamashita K, Hiwatashi A, Togao O, Kikuchi K, Momosaka D, Hata N, Akagi Y, Suzuki SO, Iwaki T, Iihara K, Honda H. Differences between primary central nervous system lymphoma and glioblastoma: topographic analysis using voxel-based morphometry. Clin Radiol. 2019 Aug 8. pii: S0009-9260(19)30311-3. doi: 10.1016/j.crad.2019.06.017. [Epub ahead of print] PubMed PMID: 31400805.
non_hodgkin_primary_central_nervous_system_lymphoma_differential_diagnosis.txt · Last modified: 2019/08/13 13:40 by administrador