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An opioid analgesic is any chemical that resembles morphine or other opiates in its pharmacological effects. Opioids work by binding to opioid receptors, which are found principally in the central and peripheral nervous system and the gastrointestinal tract. The receptors in these organ systems mediate the beneficial effects as well as the psychoactive and the side effects of opioids.

Although the term opiate is often used as a synonym for opioid, the term opiate is properly limited to the natural alkaloids found in the resin of the Papaver somniferum (opium poppy), while opioid refers to both opiates and synthetic substances, as well as to opioid peptides.

Opioids are among the world's oldest known drugs; the therapeutic use of the opium poppy predates recorded history. The analgesic (painkiller) effects of opioids are due to decreased perception of pain, decreased reaction to pain as well as increased pain tolerance. The side effects of opioids include sedation, respiratory depression, constipation, and a strong sense of euphoria. Opioids can cause cough suppression, which can be both an indication for opioid administration or an unintended side effect. Opioid dependence can develop with ongoing administration, leading to a withdrawal syndrome with abrupt discontinuation. Morphine-like opioids are not only well known for their addictive properties, but also for their ability to produce a feeling of euphoria, motivating some to use opioids recreationally.












Alfentanil, fentanyl and remifentanil are used in injectable form for postoperative analgesia. Fentanyl is also available as a self-adhesive patch.

see Tapentadol.

Opioid therapy

see Opioid therapy.

Opioids remain a mainstay in the treatment of acute and chronic pain, despite numerous and potentially dangerous side effects. There is a great unmet medical need for alternative treatments for patients suffering from pain that do not result in addiction or adverse side effects.

Since 2016, 35 of 50 USA states have passed opioid-limiting laws.

Implementation of mandatory opioid prescribing limits effectively decreased 30-day postoperative opioid utilization following ACDF without a rebound increase in prescription refills, ED visits, unplanned hospital readmissions, or reoperations for pain 1).

Opioid side effects

Countering opioid side effects 2).

Reid DBC, Patel SA, Shah KN, Shapiro BH, Ruddell JH, Akelman E, Palumbo MA, Daniels AH. Opioid-Limiting Legislation Associated with Decreased 30-Day Opioid Utilization Following Anterior Cervical Decompression and Fusion. Spine J. 2019 Sep 2. pii: S1529-9430(19)30960-X. doi: 10.1016/j.spinee.2019.08.014. [Epub ahead of print] PubMed PMID: 31487559.
Lindsay NM, Scherrer G. Countering opioid side effects. Science. 2019 Sep 20;365(6459):1246-1247. doi: 10.1126/science.aay9345. PubMed PMID: 31604226.
opioid.txt · Last modified: 2019/10/12 21:40 by administrador